Details for: LINC02519

Gene ID: 105378147

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: LINC02519

Ensembl ID: ENSG00000226194

Description: long intergenic non-protein coding RNA 2519

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • parietal epithelial cell CL1000452
    CSI 5.17
    rCSI 13.83%
    PRS 99.91
  • basal cell of epidermis CL0002187
    CSI 4.49
    rCSI 7.97%
    PRS 97.3

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [LINC02519](/details-gene/105378147) is a long intergenic non-protein coding RNA (lncRNA) located on chromosome 6q27. As a non-coding RNA, it is presumed to function as a regulatory molecule rather than being translated into a protein. **Overall**, expression data indicates that [LINC02519](/details-gene/105378147) is a highly specific marker for distinct epithelial cell populations. Its significant expression in [parietal epithelial cells](/details-cell/CL1000452) of the kidney and [basal cells of the epidermis](/details-cell/CL0002187) suggests a specialized role in maintaining the function and identity of these barrier and filtration tissues. ## Cellular Roles and Expression Landscape The expression profile of [LINC02519](/details-gene/105378147) is characterized by its high specificity for a narrow set of epithelial cells. The highest cell significance index (CSI) is observed in [parietal epithelial cells](/details-cell/CL1000452) (CSI: 5.17), which line Bowman's capsule in the kidney glomerulus and play a role in structural support and potentially progenitor cell activity. A similarly high significance is noted in [basal cells of the epidermis](/details-cell/CL0002187) (CSI: 4.49). These cells constitute the proliferative layer of the skin, responsible for self-renewal and generating differentiated keratinocytes that form the skin barrier. The prominent and specific expression in these two cell types suggests that [LINC02519](/details-gene/105378147) may be involved in fundamental epithelial processes such as maintaining a progenitor state, regulating cell division, or controlling lineage-specific gene expression programs. The distinct locations (kidney vs. skin) imply a role in context-dependent epithelial biology rather than a universal function across all epithelial tissues. ## Pathways and Molecular Function The precise molecular functions and pathways associated with [LINC02519](/details-gene/105378147) remain uncharacterized. Based on the established mechanisms of lncRNAs, it is plausible that [LINC02519](/details-gene/105378147) functions by interacting with DNA, RNA, or proteins to regulate gene expression. It could act as a molecular scaffold to assemble chromatin-modifying complexes, as a guide to direct transcription factors to specific genomic loci, or as a sponge to sequester microRNAs, thereby modulating the stability of target mRNAs. Its specific expression in basal and parietal epithelial cells suggests it could regulate key transcription factors or signaling pathways critical for the identity and function of these cells. ## Research Directions The highly restricted expression pattern of [LINC02519](/details-gene/105378147) points toward specialized functions that may be relevant in both homeostatic and pathological conditions. Investigating its expression and role in diseases affecting the kidney glomerulus (e.g., crescentic glomerulonephritis) or the skin (e.g., psoriasis, basal cell carcinoma) could provide critical insights into its function. Based on its cellular context, several testable hypotheses can be proposed: 1. [LINC02519](/details-gene/105378147) is a key regulator of proliferation and differentiation in the epidermal stem cell niche. Its knockdown would be expected to impair the self-renewal capacity of [basal cells of the epidermis](/details-cell/CL0002187) and disrupt the formation of a stratified epidermis. 2. In the kidney, [LINC02519](/details-gene/105378147) contributes to maintaining the quiescent and differentiated state of [parietal epithelial cells](/details-cell/CL1000452). Downregulation of this lncRNA during glomerular injury may be a prerequisite for the pathological activation and proliferation of these cells. To test the first hypothesis regarding its role in the skin, a compelling experimental approach would be to use antisense oligonucleotides (ASOs) or a CRISPRi system to specifically knock down [LINC02519](/details-gene/105378147) in a 3D human skin organoid model derived from primary keratinocytes. The impact on tissue architecture, proliferation (via Ki-67 staining), and differentiation (via expression of markers like Keratin 10 and Loricrin) could be assessed using histology and RNA-sequencing to identify downstream molecular pathways. Given its highly specific expression, [LINC02519](/details-gene/105378147) presents a potentially attractive therapeutic target. If its dysregulation is causally linked to hyperproliferative skin disorders or cancers, developing ASOs to inhibit its function could offer a targeted therapeutic strategy with a reduced risk of off-target effects in other tissues.