Details for: RNU6 214P

Gene ID: 106479661

Symbol: RNU6 214P

Ensembl ID: ENSG00000206857

Description: RNA, U6 small nuclear 214, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0804
    Cell Significance Index: 1.7600
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.0137
    Cell Significance Index: 0.1300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.0120
    Cell Significance Index: 0.1400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNU6-214P is a pseudogene, meaning it lacks the ability to encode a protein. However, it shares significant sequence homology with the U6 small nuclear ribonucleoprotein (snRNP), a crucial component of the spliceosome, a complex involved in RNA splicing. This homology suggests that RNU6-214P may have evolved from a functional U6 snRNP gene, but has since lost its coding capacity. Interestingly, RNU6-214P is significantly expressed in various cell types, including intestinal enteroendocrine cells, plasma cells, brush cells, and goblet cells. Its expression is also observed in abnormal and neoplastic cells, indicating a potential role in tumorigenesis. **Pathways and Functions:** While the exact function of RNU6-214P remains unclear, several hypotheses have emerged. One possibility is that it plays a role in RNA splicing, either by interacting with U6 snRNP or by influencing the expression of nearby genes. This could have implications for the regulation of gene expression, particularly in tissues with high levels of cellular turnover. Another hypothesis suggests that RNU6-214P may act as a decoy or a regulatory element, influencing the activity of nearby genes or transcripts. This could have implications for the development and progression of diseases, particularly those characterized by aberrant gene expression. **Clinical Significance:** The widespread expression of RNU6-214P across various human tissues raises several clinical questions. For example, its presence in neoplastic cells suggests that it may play a role in tumorigenesis, either as a direct oncogene or as a regulatory element influencing the expression of oncogenes. Furthermore, RNU6-214P's expression in intestinal enteroendocrine cells and goblet cells may have implications for the development of gastrointestinal disorders, such as inflammatory bowel disease or cancer. In addition, the presence of RNU6-214P in plasma cells and brush cells may have implications for the diagnosis and treatment of diseases characterized by abnormal immune responses, such as multiple myeloma or chronic inflammatory diseases. In conclusion, while the exact function of RNU6-214P remains unclear, its widespread expression across various human tissues suggests that it may play a significant role in regulating gene expression and influencing disease development. Further research is needed to fully elucidate the mechanisms underlying RNU6-214P's function and to explore its potential as a diagnostic or therapeutic target.

Database document:

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