Details for: SERPINA12

Gene ID: 145264

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: SERPINA12

Ensembl ID: ENSG00000165953

Description: serpin family A member 12

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

  • Extracellular space
    (GO:0005615)
  • Gluconeogenesis
    (GO:0006094)
  • Lipid biosynthetic process
    (GO:0008610)
  • Molecular function inhibitor activity
    (GO:0140678)
  • Negative regulation of endopeptidase activity
    (GO:0010951)
  • Negative regulation of gluconeogenesis
    (GO:0045721)
  • Negative regulation of lipid biosynthetic process
    (GO:0051055)
  • Negative regulation of peptidase activity
    (GO:0010466)
  • Phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0043491)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of insulin receptor signaling pathway
    (GO:0046628)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Protein binding
    (GO:0005515)
  • Regulation of cholesterol metabolic process
    (GO:0090181)
  • Regulation of triglyceride metabolic process
    (GO:0090207)
  • Serine-type endopeptidase inhibitor activity
    (GO:0004867)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • keratinocyte CL0000312
    CSI 9.49
    rCSI 7.96%
    PRS 99.96

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Genular Protein ID: 3098825626

Symbol: SPA12_HUMAN

Name: Serpin A12

UniProtKB Accession Codes:

Q8IW75

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 3 EvolutionaryTrace 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 8 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16030142

Title: Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity.

PubMed ID: 16030142

DOI: 10.1073/pnas.0504703102

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28668641

Title: Glycosylation of human vaspin (SERPINA12) and its impact on serpin activity, heparin binding and thermal stability.

PubMed ID: 28668641

DOI: 10.1016/j.bbapap.2017.06.020

PubMed ID: 23370777

Title: Vaspin inhibits kallikrein 7 by serpin mechanism.

PubMed ID: 23370777

DOI: 10.1007/s00018-013-1258-8

PubMed ID: 26199422

Title: A unique serpin P1' glutamate and a conserved beta-sheet C arginine are key residues for activity, protease recognition and stability of serpinA12 (vaspin).

PubMed ID: 26199422

DOI: 10.1042/bj20150643

PubMed ID: 26529565

Title: Crystal structure of cleaved vaspin (serpinA12).

PubMed ID: 26529565

DOI: 10.1515/hsz-2015-0229

PubMed ID: 27693231

Title: Mutations in the pH-sensing G-protein-coupled receptor GPR68 cause amelogenesis imperfecta.

PubMed ID: 27693231

DOI: 10.1016/j.ajhg.2016.08.020

Sequence Information:

  • Length: 414
  • Mass: 47175
  • Checksum: 5C70F1AB5935661C
  • Sequence:
    • MNPTLGLAIF LAVLLTVKGL LKPSFSPRNY KALSEVQGWK QRMAAKELAR QNMDLGFKLL 
KKLAFYNPGR NIFLSPLSIS TAFSMLCLGA QDSTLDEIKQ GFNFRKMPEK DLHEGFHYII 
HELTQKTQDL KLSIGNTLFI DQRLQPQRKF LEDAKNFYSA ETILTNFQNL EMAQKQINDF 
ISQKTHGKIN NLIENIDPGT VMLLANYIFF RARWKHEFDP NVTKEEDFFL EKNSSVKVPM 
MFRSGIYQVG YDDKLSCTIL EIPYQKNITA IFILPDEGKL KHLEKGLQVD TFSRWKTLLS 
RRVVDVSVPR LHMTGTFDLK KTLSYIGVSK IFEEHGDLTK IAPHRSLKVG EAVHKAELKM 
DERGTEGAAG TGAQTLPMET PLVVKIDKPY LLLIYSEKIP SVLFLGKIVN PIGK