No CSI details found for gene ID: 2692
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
To protect our computational resources, the in-silico analysis is available exclusively for registered users.
Genular Protein ID: 1422532056
Symbol: GHRHR_HUMAN
Name: Growth hormone-releasing hormone receptor
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1333056
Title: Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone.
PubMed ID: 1333056
PubMed ID: 7680413
Title: Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone.
PubMed ID: 7680413
PubMed ID: 12853948
PubMed ID: 8528260
Title: Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse.
PubMed ID: 8528260
DOI: 10.1038/ng0196-88
PubMed ID: 9467553
Title: Extensive phenotypic analysis of a family with growth hormone (GH) deficiency caused by a mutation in the GH-releasing hormone receptor gene.
PubMed ID: 9467553
PubMed ID: 11232012
Title: Three new mutations in the gene for the growth hormone (GH)-releasing hormone receptor in familial isolated GH deficiency type IB.
PubMed ID: 11232012
PubMed ID: 10084571
Title: Familial dwarfism due to a novel mutation of the growth hormone-releasing hormone receptor gene.
PubMed ID: 10084571
PubMed ID: 12534354
Title: A new missense mutation in the growth hormone-releasing hormone receptor gene in familial isolated GH deficiency.
PubMed ID: 12534354
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 423
- Mass: 47402
- Checksum: C9C5E2E7D6649E06
- Sequence:
MDRRMWGAHV FCVLSPLPTV LGHMHPECDF ITQLREDESA CLQAAEEMPN TTLGCPATWD GLLCWPTAGS GEWVTLPCPD FFSHFSSESG AVKRDCTITG WSEPFPPYPV ACPVPLELLA EEESYFSTVK IIYTVGHSIS IVALFVAITI LVALRRLHCP RNYVHTQLFT TFILKAGAVF LKDAALFHSD DTDHCSFSTV LCKVSVAASH FATMTNFSWL LAEAVYLNCL LASTSPSSRR AFWWLVLAGW GLPVLFTGTW VSCKLAFEDI ACWDLDDTSP YWWIIKGPIV LSVGVNFGLF LNIIRILVRK LEPAQGSLHT QSQYWRLSKS TLFLIPLFGI HYIIFNFLPD NAGLGIRLPL ELGLGSFQGF IVAILYCFLN QEVRTEISRK WHGHDPELLP AWRTRAKWTT PSRSAAKVLT SMC
Details Unavailable
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{
"geneID": 2692,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"CP068271.2"
]
},
"genePos": {
"start": 4933,
"end": 20508
},
"orientation": true,
"symbol": "GHRHR",
"created": {
"$date": {
"$numberLong": "1738333348830"
}
},
"crossReference": {
"enseGeneID": "ENSG00000106128",
"enseRnaID": [
"ENST00000326139.7"
],
"enseProtID": [
"ENSP00000320180.2"
]
},
"chrom": {
"pos": "7",
"type": 1,
"loc": "7p14.3"
},
"desc": "growth hormone releasing hormone receptor",
"geneType": 5,
"mim": [
{
"id": 139191,
"relation": 0
}
],
"ontology": [
{
"id": "R-HSA-162582",
"term": "Signal Transduction",
"cat": 10
},
{
"id": "R-HSA-372790",
"term": "Signaling by GPCR",
"cat": 11
},
{
"id": "R-HSA-388396",
"term": "GPCR downstream signalling",
"cat": 12
},
{
"id": "R-HSA-500792",
"term": "GPCR ligand binding",
"cat": 12
},
{
"id": "R-HSA-373080",
"term": "Class B\/2 (Secretin family receptors)",
"cat": 13
},
{
"id": "R-HSA-418555",
"term": "G alpha (s) signalling events",
"cat": 13
},
{
"id": "R-HSA-420092",
"term": "Glucagon-type ligand receptors",
"cat": 14
},
{
"id": "GO:0004930",
"term": "G protein-coupled receptor activity",
"pubMed": [
7680413
],
"cat": 0
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
1333056,
7680413
],
"cat": 0
},
{
"id": "GO:0008528",
"term": "G protein-coupled peptide receptor activity",
"cat": 0
},
{
"id": "GO:0016520",
"term": "growth hormone-releasing hormone receptor activity",
"cat": 0
},
{
"id": "GO:0016520",
"term": "growth hormone-releasing hormone receptor activity",
"pubMed": [
7680413
],
"cat": 0
},
{
"id": "GO:0017046",
"term": "peptide hormone binding",
"cat": 0
},
{
"id": "GO:0017046",
"term": "peptide hormone binding",
"pubMed": [
7680413
],
"cat": 0
},
{
"id": "GO:0019838",
"term": "growth factor binding",
"cat": 0
},
{
"id": "GO:0019838",
"term": "growth factor binding",
"pubMed": [
7680413
],
"cat": 0
},
{
"id": "GO:0007166",
"term": "cell surface receptor signaling pathway",
"cat": 1
},
{
"id": "GO:0007189",
"term": "adenylate cyclase-activating G protein-coupled receptor signaling pathway",
"cat": 1
},
{
"id": "GO:0007189",
"term": "adenylate cyclase-activating G protein-coupled receptor signaling pathway",
"pubMed": [
1333056,
7680413
],
"cat": 1
},
{
"id": "GO:0007595",
"term": "lactation",
"cat": 1
},
{
"id": "GO:0008284",
"term": "positive regulation of cell population proliferation",
"cat": 1
},
{
"id": "GO:0008284",
"term": "positive regulation of cell population proliferation",
"pubMed": [
12867592
],
"cat": 1
},
{
"id": "GO:0008340",
"term": "determination of adult lifespan",
"cat": 1
},
{
"id": "GO:0030252",
"term": "growth hormone secretion",
"cat": 1
},
{
"id": "GO:0032868",
"term": "response to insulin",
"pubMed": [
17356054
],
"cat": 1
},
{
"id": "GO:0032869",
"term": "cellular response to insulin stimulus",
"cat": 1
},
{
"id": "GO:0033143",
"term": "regulation of intracellular steroid hormone receptor signaling pathway",
"cat": 1
},
{
"id": "GO:0040018",
"term": "positive regulation of multicellular organism growth",
"pubMed": [
8528260
],
"cat": 1
},
{
"id": "GO:0042445",
"term": "hormone metabolic process",
"cat": 1
},
{
"id": "GO:0043568",
"term": "positive regulation of insulin-like growth factor receptor signaling pathway",
"pubMed": [
11773624
],
"cat": 1
},
{
"id": "GO:0043627",
"term": "response to estrogen",
"pubMed": [
9482665
],
"cat": 1
},
{
"id": "GO:0048469",
"term": "cell maturation",
"cat": 1
},
{
"id": "GO:0048609",
"term": "multicellular organismal reproductive process",
"pubMed": [
15944917
],
"cat": 1
},
{
"id": "GO:0051246",
"term": "regulation of protein metabolic process",
"cat": 1
},
{
"id": "GO:0051384",
"term": "response to glucocorticoid",
"pubMed": [
9482665
],
"cat": 1
},
{
"id": "GO:0051649",
"term": "establishment of localization in cell",
"cat": 1
},
{
"id": "GO:0060124",
"term": "positive regulation of growth hormone secretion",
"pubMed": [
11773624
],
"cat": 1
},
{
"id": "GO:0060133",
"term": "somatotropin secreting cell development",
"cat": 1
},
{
"id": "GO:0005637",
"term": "nuclear inner membrane",
"pubMed": [
10461027
],
"cat": 2
},
{
"id": "GO:0005640",
"term": "nuclear outer membrane",
"pubMed": [
10461027
],
"cat": 2
},
{
"id": "GO:0005737",
"term": "cytoplasm",
"pubMed": [
10461027
],
"cat": 2
},
{
"id": "GO:0005886",
"term": "plasma membrane",
"cat": 2
},
{
"id": "GO:0005886",
"term": "plasma membrane",
"pubMed": [
10461027
],
"cat": 2
},
{
"id": "GO:0009986",
"term": "cell surface",
"pubMed": [
1333056
],
"cat": 2
},
{
"id": "GO:0016020",
"term": "membrane",
"pubMed": [
1333056
],
"cat": 2
},
{
"id": "GO:0016363",
"term": "nuclear matrix",
"pubMed": [
10461027
],
"cat": 2
},
{
"id": "GO:0030141",
"term": "secretory granule",
"pubMed": [
10461027
],
"cat": 2
}
],
"protein": [
{
"symbol": "GHRHR_HUMAN",
"name": "Growth hormone-releasing hormone receptor",
"accession": [
"Q02643",
"Q99863"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"MIM": [
"618157",
"139191",
"618157"
],
"EMBL": [
"L01406",
"L09237",
"AB065701",
"AY557192",
"AC005155",
"U42225",
"U42222",
"U42223",
"U42224"
],
"CCDS": [
"CCDS5432.1"
],
"PIR": [
"A45363"
],
"RefSeq": [
"NP_000814.2"
],
"PDB": [
"2XDG",
"7CZ5"
],
"PDBsum": [
"2XDG",
"7CZ5"
],
"AlphaFoldDB": [
"Q02643"
],
"EMDB": [
"EMD-30505"
],
"SMR": [
"Q02643"
],
"BioGRID": [
"108959"
],
"STRING": [
"9606.ENSP00000320180"
],
"BindingDB": [
"Q02643"
],
"ChEMBL": [
"CHEMBL2032"
],
"DrugBank": [
"DB00010",
"DB08869"
],
"DrugCentral": [
"Q02643"
],
"GuidetoPHARMACOLOGY": [
"247"
],
"TCDB": [
"9.A.14.4.7"
],
"GlyCosmos": [
"Q02643"
],
"GlyGen": [
"Q02643"
],
"PhosphoSitePlus": [
"Q02643"
],
"BioMuta": [
"GHRHR"
],
"DMDM": [
"3041685"
],
"PaxDb": [
"9606-ENSP00000320180"
],
"PeptideAtlas": [
"Q02643"
],
"Antibodypedia": [
"3360"
],
"DNASU": [
"2692"
],
"Ensembl": [
"ENST00000326139.7"
],
"KEGG": [
"hsa:2692"
],
"MANE-Select": [
"ENST00000326139.7"
],
"UCSC": [
"uc003tbx.4"
],
"AGR": [
"HGNC:4266"
],
"CTD": [
"2692"
],
"DisGeNET": [
"2692"
],
"GeneCards": [
"GHRHR"
],
"HGNC": [
"HGNC:4266"
],
"HPA": [
"ENSG00000106128"
],
"MalaCards": [
"GHRHR"
],
"neXtProt": [
"NX_Q02643"
],
"OpenTargets": [
"ENSG00000106128"
],
"Orphanet": [
"231671"
],
"PharmGKB": [
"PA28676"
],
"VEuPathDB": [
"HostDB:ENSG00000106128"
],
"eggNOG": [
"KOG4564"
],
"GeneTree": [
"ENSGT00940000159858"
],
"InParanoid": [
"Q02643"
],
"OMA": [
"RAWGACI"
],
"OrthoDB": [
"5252868at2759"
],
"PhylomeDB": [
"Q02643"
],
"TreeFam": [
"TF315710"
],
"PathwayCommons": [
"Q02643"
],
"Reactome": [
"R-HSA-418555",
"R-HSA-420092"
],
"SignaLink": [
"Q02643"
],
"BioGRID-ORCS": [
"2692"
],
"ChiTaRS": [
"GHRHR"
],
"EvolutionaryTrace": [
"Q02643"
],
"GeneWiki": [
"Growth-hormone-releasing_hormone_receptor",
"Growth_hormone-releasing_hormone_receptor"
],
"GenomeRNAi": [
"2692"
],
"Pharos": [
"Q02643"
],
"PRO": [
"PR:Q02643"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"Q02643"
],
"Bgee": [
"ENSG00000106128"
],
"ExpressionAtlas": [
"Q02643"
],
"GO": [
"GO:0009986",
"GO:0005737",
"GO:0016020",
"GO:0005637",
"GO:0016363",
"GO:0005640",
"GO:0005886",
"GO:0030141",
"GO:0008528",
"GO:0004930",
"GO:0019838",
"GO:0016520",
"GO:0017046",
"GO:0007189",
"GO:0048469",
"GO:0007166",
"GO:0032869",
"GO:0008340",
"GO:0051649",
"GO:0030252",
"GO:0042445",
"GO:0007595",
"GO:0048609",
"GO:0008284",
"GO:0060124",
"GO:0043568",
"GO:0040018",
"GO:0033143",
"GO:0051246",
"GO:0043627",
"GO:0051384",
"GO:0032868",
"GO:0060133"
],
"Gene3D": [
"4.10.1240.10",
"1.20.1070.10"
],
"InterPro": [
"IPR050332",
"IPR017981",
"IPR036445",
"IPR001879",
"IPR003288",
"IPR000832",
"IPR017983"
],
"PANTHER": [
"PTHR45620:SF14",
"PTHR45620"
],
"Pfam": [
"PF00002",
"PF02793"
],
"PRINTS": [
"PR01352",
"PR00249"
],
"SMART": [
"SM00008"
],
"SUPFAM": [
"SSF81321",
"SSF111418"
],
"PROSITE": [
"PS00649",
"PS00650",
"PS50227",
"PS50261"
]
},
"citations": [
{
"title": "Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone.",
"pubmedID": "1333056",
"doi": "10.1210\/mend.6.10.1333056"
},
{
"title": "Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone.",
"pubmedID": "7680413",
"doi": "10.1210\/mend.7.1.7680413"
},
{
"title": "The DNA sequence of human chromosome 7.",
"pubmedID": "12853948",
"doi": "10.1038\/nature01782"
},
{
"title": "Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse.",
"pubmedID": "8528260",
"doi": "10.1038\/ng0196-88"
},
{
"title": "Extensive phenotypic analysis of a family with growth hormone (GH) deficiency caused by a mutation in the GH-releasing hormone receptor gene.",
"pubmedID": "9467553",
"doi": "10.1210\/jcem.83.2.4528"
},
{
"title": "Three new mutations in the gene for the growth hormone (GH)-releasing hormone receptor in familial isolated GH deficiency type IB.",
"pubmedID": "11232012",
"doi": "10.1210\/jcem.86.1.7156"
},
{
"title": "Familial dwarfism due to a novel mutation of the growth hormone-releasing hormone receptor gene.",
"pubmedID": "10084571",
"doi": "10.1210\/jcem.84.3.5599"
},
{
"title": "A new missense mutation in the growth hormone-releasing hormone receptor gene in familial isolated GH deficiency.",
"pubmedID": "12534354",
"doi": "10.1530\/eje.0.1480025"
},
{
"title": "The consensus coding sequences of human breast and colorectal cancers.",
"pubmedID": "16959974",
"doi": "10.1126\/science.1133427"
}
],
"sequence": {
"length": 423,
"mass": 47402,
"checksum": "C9C5E2E7D6649E06",
"modified": {
"$date": {
"$numberLong": "900460800000"
}
},
"version": 2,
"sequence": "MDRRMWGAHVFCVLSPLPTVLGHMHPECDFITQLREDESACLQAAEEMPNTTLGCPATWDGLLCWPTAGSGEWVTLPCPDFFSHFSSESGAVKRDCTITGWSEPFPPYPVACPVPLELLAEEESYFSTVKIIYTVGHSISIVALFVAITILVALRRLHCPRNYVHTQLFTTFILKAGAVFLKDAALFHSDDTDHCSFSTVLCKVSVAASHFATMTNFSWLLAEAVYLNCLLASTSPSSRRAFWWLVLAGWGLPVLFTGTWVSCKLAFEDIACWDLDDTSPYWWIIKGPIVLSVGVNFGLFLNIIRILVRKLEPAQGSLHTQSQYWRLSKSTLFLIPLFGIHYIIFNFLPDNAGLGIRLPLELGLGSFQGFIVAILYCFLNQEVRTEISRKWHGHDPELLPAWRTRAKWTTPSRSAAKVLTSMC"
},
"existence": 0,
"relevance": 1,
"proteinID": 1422532056
}
],
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}