Details for: GHRHR

Gene ID: 2692

Symbol: GHRHR

Ensembl ID: ENSG00000106128

Description: growth hormone releasing hormone receptor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 3.88
    Marker Score: 8023
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.12
    Marker Score: 2135.5
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.96
    Marker Score: 2189
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.94
    Marker Score: 3672
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1174
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.56
    Marker Score: 1553.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 859
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 489
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4815
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 505
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.1
    Marker Score: 2581
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.07
    Marker Score: 593
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48050
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.86
    Marker Score: 13407
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.84
    Marker Score: 488
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.84
    Marker Score: 265
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.8
    Marker Score: 1618
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.67
    Marker Score: 1081
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.66
    Marker Score: 387
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.59
    Marker Score: 308.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 466
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.56
    Marker Score: 266
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.53
    Marker Score: 542
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.53
    Marker Score: 319
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.36
    Marker Score: 114
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.35
    Marker Score: 161
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.32
    Marker Score: 308
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.32
    Marker Score: 83
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.27
    Marker Score: 87
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.26
    Marker Score: 96
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.25
    Marker Score: 111
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.2
    Marker Score: 116
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.19
    Marker Score: 168
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.19
    Marker Score: 1975
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.19
    Marker Score: 234
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.17
    Marker Score: 501
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.17
    Marker Score: 190
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.16
    Marker Score: 74
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.16
    Marker Score: 141
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.16
    Marker Score: 64
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.14
    Marker Score: 86.5
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.12
    Marker Score: 215
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.12
    Marker Score: 174
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.12
    Marker Score: 124.5
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.11
    Marker Score: 66
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.1
    Marker Score: 97
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.1
    Marker Score: 35
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.1
    Marker Score: 58
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.1
    Marker Score: 119
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.1
    Marker Score: 63
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.09
    Marker Score: 100
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.09
    Marker Score: 24.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.09
    Marker Score: 127
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.09
    Marker Score: 367
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.09
    Marker Score: 34
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.08
    Marker Score: 32
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.08
    Marker Score: 85
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.08
    Marker Score: 2916
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.08
    Marker Score: 40
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.07
    Marker Score: 83
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.07
    Marker Score: 1438
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.06
    Marker Score: 94
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.06
    Marker Score: 339
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.06
    Marker Score: 219
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.06
    Marker Score: 60
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.05
    Marker Score: 21

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Other Information

**Key characteristics:** * GHRHR is a transmembrane protein that is composed of 145 amino acids. * It is a member of the G protein-coupled receptor (GPCR) family of cell surface receptors. * GHRHR is expressed in high levels in the pituitary gland and other endocrine glands. * It is also expressed in some tissues in the central nervous system, including the hypothalamus and pituitary gland. **Pathways and functions:** * GHRHR is a key regulator of growth and development. * It is expressed in high levels in the pituitary gland and other endocrine glands, where it is responsible for regulating growth and reproduction. * It is also expressed in some tissues in the central nervous system, where it is involved in regulating sleep-wake cycles and other physiological processes. * GHRHR signaling is mediated by the activation of the adenylate cyclase-activating g protein-coupled receptor (AC-GPCR) pathway. * The AC-GPCR pathway is a major regulator of growth and development, and its activation by GHRHR is essential for the growth of new tissue. * GHRHR signaling can also activate the cell surface receptor signaling pathway, the G alpha (s) signaling events, and the G protein-coupled peptide receptor activity pathways. **Clinical significance:** * GHRHR is a key target for the treatment of cancer. * Inhibition of GHRHR signaling has been shown to inhibit growth and proliferation of cancer cells. * This has led to the development of a number of drugs that are used to treat cancer, including growth hormone receptor blockers (GHRBs). **Conclusion:** The GHRHR is a key regulator of growth and development. Its expression is often associated with cancer, and its inhibition has been shown to inhibit growth and proliferation of cancer cells. GHRBs are a class of drugs that are used to treat cancer, and they are a promising new treatment for this disease.

Genular Protein ID: 1422532056

Symbol: GHRHR_HUMAN

Name: Growth hormone-releasing hormone receptor

UniProtKB Accession Codes:

Q02643 Q99863

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 9 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 34 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 2 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 1333056

Title: Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone.

PubMed ID: 1333056

DOI: 10.1210/mend.6.10.1333056

PubMed ID: 7680413

Title: Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone.

PubMed ID: 7680413

DOI: 10.1210/mend.7.1.7680413

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 8528260

Title: Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse.

PubMed ID: 8528260

DOI: 10.1038/ng0196-88

PubMed ID: 9467553

Title: Extensive phenotypic analysis of a family with growth hormone (GH) deficiency caused by a mutation in the GH-releasing hormone receptor gene.

PubMed ID: 9467553

DOI: 10.1210/jcem.83.2.4528

PubMed ID: 11232012

Title: Three new mutations in the gene for the growth hormone (GH)-releasing hormone receptor in familial isolated GH deficiency type IB.

PubMed ID: 11232012

DOI: 10.1210/jcem.86.1.7156

PubMed ID: 10084571

Title: Familial dwarfism due to a novel mutation of the growth hormone-releasing hormone receptor gene.

PubMed ID: 10084571

DOI: 10.1210/jcem.84.3.5599

PubMed ID: 12534354

Title: A new missense mutation in the growth hormone-releasing hormone receptor gene in familial isolated GH deficiency.

PubMed ID: 12534354

DOI: 10.1530/eje.0.1480025

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 423
  • Mass: 47402
  • Checksum: C9C5E2E7D6649E06
  • Sequence:
    • MDRRMWGAHV FCVLSPLPTV LGHMHPECDF ITQLREDESA CLQAAEEMPN TTLGCPATWD 
GLLCWPTAGS GEWVTLPCPD FFSHFSSESG AVKRDCTITG WSEPFPPYPV ACPVPLELLA 
EEESYFSTVK IIYTVGHSIS IVALFVAITI LVALRRLHCP RNYVHTQLFT TFILKAGAVF 
LKDAALFHSD DTDHCSFSTV LCKVSVAASH FATMTNFSWL LAEAVYLNCL LASTSPSSRR 
AFWWLVLAGW GLPVLFTGTW VSCKLAFEDI ACWDLDDTSP YWWIIKGPIV LSVGVNFGLF 
LNIIRILVRK LEPAQGSLHT QSQYWRLSKS TLFLIPLFGI HYIIFNFLPD NAGLGIRLPL 
ELGLGSFQGF IVAILYCFLN QEVRTEISRK WHGHDPELLP AWRTRAKWTT PSRSAAKVLT 
SMC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.