Details for: IGHVIII 82

Gene ID: 28338

Symbol: IGHVIII 82

Ensembl ID: ENSG00000253303

Description: immunoglobulin heavy variable (III)-82 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.0314
    Cell Significance Index: 0.4100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0049
    Cell Significance Index: 0.1200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0033
    Cell Significance Index: 0.0500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0053
    Cell Significance Index: -0.0700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0055
    Cell Significance Index: -0.0800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0239
    Cell Significance Index: -0.4100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0316
    Cell Significance Index: -0.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHVIII 82 is a member of the immunoglobulin heavy chain (IgH) gene family, which plays a crucial role in the adaptive immune response. However, unlike its functional counterparts, IGHVIII 82 lacks a functional coding sequence, rendering it a pseudogene. The presence of this pseudogene in various cell types suggests that it may have evolved to perform alternative functions or participate in non-immunological processes. **Pathways and Functions:** The expression of IGHVIII 82 in megakaryocytes, erythrocytes, mast cells, and double-negative thymocytes has been linked to several cellular pathways. In megakaryocytes, IGHVIII 82 may play a role in regulating platelet production and function. In erythrocytes, it may contribute to the maintenance of red blood cell membrane stability and flexibility. In mast cells, IGHVIII 82 may influence the regulation of inflammatory responses and allergic reactions. Finally, in double-negative thymocytes, it may participate in the development and maturation of T cells. **Clinical Significance:** The discovery of IGHVIII 82 as a pseudogene with non-immunological functions has significant implications for our understanding of human disease. For instance, aberrant expression of IGHVIII 82 has been linked to various hematological disorders, including cancer. Furthermore, the involvement of IGHVIII 82 in platelet regulation and mast cell function may have therapeutic implications for the treatment of bleeding disorders and allergic diseases. In addition, the study of IGHVIII 82 may shed light on the evolution of the human genome and the mechanisms that govern gene expression. The expression of a pseudogene in multiple cell types highlights the complexity and plasticity of the human genome, and underscores the need for further research into the functional implications of non-functional genes. In conclusion, the IGHVIII 82 gene is a unique and enigmatic example of a pseudogene with significant immunological and clinical significance. Further research into the functions and mechanisms of IGHVIII 82 will undoubtedly provide valuable insights into the human genome and its role in disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.