Details for: IGHVII 28 1

Gene ID: 28372

Symbol: IGHVII 28 1

Ensembl ID: ENSG00000253149

Description: immunoglobulin heavy variable (II)-28-1 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: B cell (CL0000236)
    Fold Change: 0.0422
    Cell Significance Index: 0.5000
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.0070
    Cell Significance Index: 0.0600
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.0012
    Cell Significance Index: 0.0100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.0012
    Cell Significance Index: 0.0100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0095
    Cell Significance Index: -0.1100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0156
    Cell Significance Index: -0.1500
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0329
    Cell Significance Index: -0.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** The IGHVII28-1 gene is a pseudogene, meaning it has undergone significant mutations and deletions, resulting in a non-functional gene. However, this does not preclude its potential regulatory functions. 2. **Expression in diverse immune cells:** The IGHVII28-1 gene is expressed in multiple immune cell types, including B cells, effector CD4-positive T cells, alpha-beta T cells, memory B cells, and CD4-positive helper T cells. 3. **Variable expression patterns:** The expression of IGHVII28-1 is not uniform across different immune cell types, suggesting a cell-type-specific or context-dependent regulation of its expression. 4. **Structural homology to functional genes:** The IGHVII28-1 gene shares structural homology with functional immunoglobulin heavy chain genes, suggesting a possible evolutionary origin from a functional gene. **Pathways and Functions:** 1. **Regulation of immune cell activation:** The IGHVII28-1 gene may play a role in regulating immune cell activation, particularly in the context of T cell responses. Its expression in effector CD4-positive T cells and alpha-beta T cells suggests a potential involvement in T cell activation and proliferation. 2. **Modulation of immune cell differentiation:** The IGHVII28-1 gene may also contribute to the regulation of immune cell differentiation, particularly in the context of B cell development. Its expression in memory B cells and naive thymus-derived CD4-positive T cells suggests a possible role in B cell differentiation and T cell development. 3. **Influence on cytokine production:** The IGHVII28-1 gene may also influence cytokine production in immune cells, particularly in the context of CD4-positive helper T cell responses. Its expression in CD4-positive helper T cells suggests a potential role in regulating cytokine production and immune responses. **Clinical Significance:** 1. **Immunodeficiency disorders:** The IGHVII28-1 gene may contribute to immunodeficiency disorders, such as X-linked agammaglobulinemia, which is characterized by impaired B cell development and function. 2. **Autoimmune diseases:** The IGHVII28-1 gene may also play a role in autoimmune diseases, such as multiple sclerosis, which is characterized by dysregulated immune responses and immune cell activation. 3. **Cancer immunology:** The IGHVII28-1 gene may influence cancer immunology, particularly in the context of tumor-associated immune cell responses. Its expression in CD4-positive helper T cells suggests a potential role in regulating tumor-associated immune responses. In conclusion, the IGHVII28-1 gene is a complex immunoglobulin heavy chain pseudogene that has been identified in various immune cells, suggesting a diverse range of functions, including regulation of immune cell activation, differentiation, and cytokine production. Further studies are needed to elucidate the mechanisms by which the IGHVII28-1 gene influences immune responses and to explore its potential applications in immunotherapy and disease treatment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.