Details for: CD200R1L

Gene ID: 344807

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CD200R1L

Ensembl ID: ENSG00000206531

Description: CD200 receptor 1 like

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • ciliated cell CL0000064
    CSI 4.27
    rCSI 6.92%
    PRS 99.93
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 1.49
    rCSI 5.63%
    PRS 99.87

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [CD200R1L](/details-gene/344807), or CD200 receptor 1 like, is a protein-coding gene located on chromosome 3q13.2. It encodes a cell surface glycoprotein, also known as CD200 receptor 2, which is a member of the CD200 receptor family of immunoregulatory molecules [Link](https://doi.org/10.4049/jimmunol.171.6.3034). Functional annotations indicate that [CD200R1L](/details-gene/344807) functions as a signaling receptor on the plasma membrane, where it is involved in protein binding and the regulation of neuroinflammatory responses. Expression data highlights its particularly high significance in [ciliated cells](/details-cell/CL0000064) and notable expression in specific neuronal subtypes, suggesting specialized roles in both epithelial barrier tissues and the central nervous system. ## Cellular Roles and Expression Landscape **Overall**, the expression profile of [CD200R1L](/details-gene/344807) points towards a specialized function in distinct cell populations rather than a ubiquitous role. The most significant expression is observed in [ciliated cells](/details-cell/CL0000064) (CSI: 4.27), indicating it may serve as a key functional molecule or marker for this cell type. Ciliated cells are critical for mucociliary clearance in the respiratory tract and other organs, suggesting a potential role for [CD200R1L](/details-gene/344807) in modulating immune surveillance at these environmental interfaces. Additionally, [CD200R1L](/details-gene/344807) shows significant expression in [near-projecting glutamatergic cortical neurons](/details-cell/CL4023012) (CSI: 1.49). This finding is consistent with its annotated role in neuroinflammation and suggests it may participate in neuron-glia communication to maintain immune homeostasis within the cerebral cortex. The structural and functional heterogeneity within the CD200R family, as noted in previous research, may allow [CD200R1L](/details-gene/344807) to perform distinct immunoregulatory functions depending on its cellular context [Link](https://doi.org/10.1111/j.1600-0897.2004.00192.x). ## Pathways and Molecular Function The molecular function of [CD200R1L](/details-gene/344807) is centered on its identity as a transmembrane receptor. As specified by its Gene Ontology annotations, it is located on the [external side of plasma membrane](/details-cell/GO:0009897) and possesses [signaling receptor activity](/details-cell/GO:0038023) and the capacity for [protein binding](/details-cell/GO:0005515). These molecular characteristics are integral to its primary annotated biological process: the [regulation of neuroinflammatory response](/details-cell/GO:0150077). This function aligns well with its expression in cortical neurons, where it may interact with ligands on immune cells like microglia to dampen inflammatory signaling pathways. While its role in neuroinflammation is suggested, its specific function in [ciliated cells](/details-cell/CL0000064), where its expression is most significant, remains less defined by current annotations and may represent a novel area of investigation. ## Research Directions The unique expression pattern and immunoregulatory-associated function of [CD200R1L](/details-gene/344807) suggest several avenues for future research. The data prompts hypotheses aimed at elucidating its specific roles in both neuronal and non-neuronal contexts. **Proposed Hypotheses:** 1. In [ciliated cells](/details-cell/CL0000064) of the respiratory epithelium, [CD200R1L](/details-gene/344807) acts as an inhibitory receptor that, upon engagement, suppresses the pro-inflammatory response to inhaled pathogens or irritants, thereby contributing to the maintenance of mucosal immune tolerance. 2. Within the cortex, [CD200R1L](/details-gene/344807) expressed on [near-projecting glutamatergic cortical neurons](/details-cell/CL4023012) functions to limit microglial activation and phagocytosis, serving as a "don't-eat-me" signal that protects neuronal integrity under conditions of low-grade inflammation. **Experimental Approach:** To test the first hypothesis regarding its role in [ciliated cells](/details-cell/CL0000064), an *in vitro* study using air-liquid interface (ALI) cultures of human bronchial epithelial cells could be performed. Following differentiation, these cultures develop a polarized epithelium rich in ciliated cells. [CD200R1L](/details-gene/344807) expression could be knocked down using lentiviral-delivered shRNA. Control and knockdown cultures would then be challenged with a pro-inflammatory stimulus, such as lipopolysaccharide (LPS). The functional consequence of [CD200R1L](/details-gene/344807) loss would be assessed by measuring the secretion of key inflammatory cytokines (e.g., IL-6, IL-8, TNF-α) into the basolateral medium via ELISA or multiplex assay. An exaggerated cytokine response in knockdown cultures would support the hypothesis that [CD200R1L](/details-gene/344807) has an inflammation-dampening function in the airway epithelium. **Therapeutic Potential:** As a cell surface receptor involved in regulating inflammation, [CD200R1L](/details-gene/344807) presents a plausible therapeutic target. Given its likely inhibitory function, similar to other CD200R family members, agonistic targeting would be the probable strategy. The development of a monoclonal antibody or small molecule agonist that activates [CD200R1L](/details-gene/344807) signaling could represent a novel therapeutic approach for neuroinflammatory disorders such as multiple sclerosis or Alzheimer's disease, where reducing chronic inflammation is a key goal. Its specific expression pattern suggests that such a therapy could potentially achieve targeted effects, although off-target effects in ciliated tissues would need to be carefully evaluated.

Genular Protein ID: 872889924

Symbol: MO2R2_HUMAN

Name: Cell surface glycoprotein CD200 receptor 2

UniProtKB Accession Codes:

Q6Q8B3 Q6WHB7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12960329

Title: Characterization of the CD200 receptor family in mice and humans and their interactions with CD200.

PubMed ID: 12960329

DOI: 10.4049/jimmunol.171.6.3034

PubMed ID: 15274657

Title: Structural and functional heterogeneity in the CD200R family of immunoregulatory molecules and their expression at the feto-maternal interface.

PubMed ID: 15274657

DOI: 10.1111/j.1600-0897.2004.00192.x

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 271
  • Mass: 29920
  • Checksum: 9D8E3074F7D34F90
  • Sequence:
    • MSAPRLLISI IIMVSASSSS CMGGKQMTQN YSTIFAEGNI SQPVLMDINA VLCCPPIALR 
NLIIITWEII LRGQPSCTKA YKKETNETKE TNCTVERITW VSRPDQNSDL QIRPVDTTHD 
GYYRGIVVTP DGNFHRGYHL QVLVTPEVNL FQSRNITAVC KAVTGKPAAQ ISWIPEGSIL 
ATKQEYWGNG TVTVKSTCPW EGHKSTVTCH VSHLTGNKSL SVKLNSGLRT SGSPALSLLI 
ILYVKLSLFV VILVTTGFVF FQRINHVRKV L