Details for: LINC01193

Gene ID: 348120

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: LINC01193

Ensembl ID: ENSG00000258710

Description: long intergenic non-protein coding RNA 1193

Cell Significance Landscape

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 1.52
    rCSI 5.75%
    PRS 99.9

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [LINC01193](/details-gene/348120) is a long intergenic non-coding RNA (lncRNA) located on chromosome 15q11.2. Based on the available expression data, this gene exhibits a highly specific expression profile, suggesting it may function as a specialized marker. **Overall**, its significance is almost exclusively confined to a distinct neuronal population, the [near-projecting glutamatergic cortical neuron](/details-cell/CL4023012), indicating a potential role in the identity or function of this specific cell type within the cerebral cortex. ## Cellular Roles and Expression Landscape The expression pattern of [LINC01193](/details-gene/348120) points towards a highly specialized role within the central nervous system. The **Overall** context analysis identifies it as a significant gene (CSI: 1.52) solely in [near-projecting glutamatergic cortical neuron](/details-cell/CL4023012). This restricted expression suggests that [LINC01193](/details-gene/348120) is not a broadly expressed housekeeping gene but is instead likely involved in processes unique to this neuronal subtype. The absence of significant expression in other cell types, including other neuronal populations or glial cells, underscores its potential as a highly specific cellular identity marker. This restricted pattern suggests its function may be related to the development, maintenance, or specialized electrophysiological properties of near-projecting glutamatergic cortical neurons. ## Pathways and Molecular Function The specific molecular functions and biological pathways involving [LINC01193](/details-gene/348120) remain to be elucidated, as functional annotation data is not available. As a long non-coding RNA, it is plausible that it functions through mechanisms common to this class of molecules, such as acting as a scaffold for protein complexes, a guide for chromatin-modifying enzymes, or a sponge for microRNAs. Its specific expression in cortical neurons suggests it may regulate gene expression programs essential for neuronal identity and synaptic function. ## Research Directions The highly specific expression of [LINC01193](/details-gene/348120) in a single neuronal subtype provides a clear avenue for investigation into its role in cortical neurobiology and its potential involvement in neurological disorders. ### Proposed Hypotheses: 1. **Hypothesis 1:** [LINC01193](/details-gene/348120) is a critical regulator of neuronal identity and maturation for [near-projecting glutamatergic cortical neuron](/details-cell/CL4023012). Its expression may be required to establish or maintain the specific gene expression programs that define this cell's connectivity and function. 2. **Hypothesis 2:** [LINC01193](/details-gene/348120) modulates synaptic plasticity or neurotransmission specifically within this neuronal population. As a lncRNA, it could localize to synaptic compartments and regulate the local translation of mRNAs crucial for synaptic function. ### Experimental Approach: To test the hypothesis that [LINC01193](/details-gene/348120) is essential for the maturation and function of its host neuron (Hypothesis 1), a targeted loss-of-function study could be performed. Using human induced pluripotent stem cells (iPSCs) differentiated into cortical neurons, CRISPR-Cas9-mediated knockout or CRISPRi-mediated knockdown of [LINC01193](/details-gene/348120) could be implemented. The resulting neuronal cultures could then be analyzed using single-cell RNA-sequencing to determine if the loss of [LINC01193](/details-gene/348120) leads to a failure in differentiation, a shift in cell identity, or dysregulation of key neuronal genes. Furthermore, patch-clamp electrophysiology could be employed to assess functional consequences, such as altered firing patterns or synaptic transmission. ### Therapeutic Potential: The therapeutic potential of [LINC01193](/details-gene/348120) is currently speculative and entirely dependent on establishing a functional link to a specific neurological or psychiatric disease. Given its extremely restricted expression, it presents an attractive profile for a therapeutic target, as off-target effects in other cell types would be minimized. If dysregulation of [LINC01193](/details-gene/348120) were implicated in a disorder affecting cortical circuits, such as certain forms of epilepsy or schizophrenia, it could be a candidate for modulation using RNA-targeting therapies like antisense oligonucleotides (ASOs), which could be delivered to the central nervous system to either inhibit or potentially augment its expression.