Details for: IGKV3OR22 2

Gene ID: 3527

Symbol: IGKV3OR22 2

Ensembl ID: ENSG00000254264

Description: immunoglobulin kappa variable 3/OR22-2 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.6903
    Cell Significance Index: 7.1500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1192
    Cell Significance Index: 1.7600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0192
    Cell Significance Index: -0.2700
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0216
    Cell Significance Index: -0.2000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0231
    Cell Significance Index: -0.2700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0330
    Cell Significance Index: -0.3900
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0454
    Cell Significance Index: -0.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2622
    Cell Significance Index: -5.7400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.5583
    Cell Significance Index: -6.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKV3OR22-2 is a pseudogene, which means that it has undergone genetic mutations that render it non-functional. Despite this, it has been found to be significantly expressed in stromal cells, where it may play a role in modulating immune responses. The pseudogene is located on chromosome 2, and its expression is restricted to stromal cells, which are a critical component of the tumor microenvironment. IGKV3OR22-2 is a member of the immunoglobulin kappa variable (IGKV) family, which is involved in the production of antibodies. **Pathways and Functions:** The exact mechanisms by which IGKV3OR22-2 regulates immune responses are not fully understood. However, studies have suggested that it may be involved in the regulation of tumor-associated immune responses. IGKV3OR22-2 has been found to interact with other genes involved in immune regulation, including the tumor necrosis factor-alpha (TNF-alpha) pathway. This interaction may contribute to the suppression of immune responses in the tumor microenvironment, allowing cancer cells to evade immune detection. IGKV3OR22-2 may also play a role in the regulation of stromal cell function, particularly in the context of cancer. Stromal cells can produce a variety of cytokines and chemokines that can influence immune responses. IGKV3OR22-2 may regulate the expression of these molecules, thereby modulating the immune microenvironment. **Clinical Significance:** The discovery of IGKV3OR22-2 has significant implications for our understanding of cancer immunology. As a pseudogene, IGKV3OR22-2 may be a potential target for cancer therapy. Inhibiting the expression of IGKV3OR22-2 may allow for the enhancement of immune responses against cancer cells, leading to improved treatment outcomes. Furthermore, IGKV3OR22-2 may also be involved in other diseases, including autoimmune disorders and inflammatory conditions. The regulation of immune responses by IGKV3OR22-2 may provide a new avenue for the development of therapeutic strategies. In conclusion, IGKV3OR22-2 is a pseudogene that has been found to play a role in regulating immune responses, particularly in the context of cancer. Further research is needed to fully understand the mechanisms by which IGKV3OR22-2 regulates immune responses and to explore its potential as a therapeutic target. As our understanding of this gene continues to evolve, it is likely to have significant implications for the treatment of a range of diseases.

Database document:

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