Details for: KIR2DL1

Gene ID: 3802

Symbol: KIR2DL1

Ensembl ID: ENSG00000125498

Description: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8272
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3172
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.03
    Marker Score: 5620
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71825
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2426
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.9
    Marker Score: 690
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.87
    Marker Score: 2544
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.83
    Marker Score: 1345
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.82
    Marker Score: 267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 483
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.57
    Marker Score: 551
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5
    Marker Score: 210
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 477
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.42
    Marker Score: 223
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.41
    Marker Score: 392
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.38
    Marker Score: 292
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.38
    Marker Score: 218
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.38
    Marker Score: 553
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.37
    Marker Score: 189
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.34
    Marker Score: 339
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.33
    Marker Score: 188
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.32
    Marker Score: 360
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.27
    Marker Score: 442
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.27
    Marker Score: 346
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.26
    Marker Score: 235
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.25
    Marker Score: 144
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.25
    Marker Score: 393
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.23
    Marker Score: 153.5
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.23
    Marker Score: 202
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.18
    Marker Score: 105
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.17
    Marker Score: 78
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.16
    Marker Score: 117
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.15
    Marker Score: 49
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.15
    Marker Score: 120
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.14
    Marker Score: 232
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.13
    Marker Score: 227
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.12
    Marker Score: 83
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.12
    Marker Score: 389
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.12
    Marker Score: 380
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.12
    Marker Score: 159
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.11
    Marker Score: 53
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.11
    Marker Score: 27
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.1
    Marker Score: 65
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.1
    Marker Score: 83
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.1
    Marker Score: 96
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.09
    Marker Score: 223
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.09
    Marker Score: 83
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.09
    Marker Score: 53
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.09
    Marker Score: 1002
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.08
    Marker Score: 45
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.08
    Marker Score: 64
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: type II NK T cell (CL0000922)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.07
    Marker Score: 153
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 136
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.06
    Marker Score: 50
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.06
    Marker Score: 34
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.06
    Marker Score: 62
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.06
    Marker Score: 34
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.05
    Marker Score: 47
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.05
    Marker Score: 99
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.05
    Marker Score: 51
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.04
    Marker Score: 45
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.04
    Marker Score: 73
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.04
    Marker Score: 256
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.04
    Marker Score: 90
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.03
    Marker Score: 17

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * KIR2DL1 is a type I transmembrane receptor that is expressed as a single polypeptide chain. * It is a member of the KIR family of immune receptors, which are characterized by the presence of two Ig domains and a long cytoplasmic tail. * KIR2DL1 is expressed on the surface of a variety of immune cells, including natural killer cells, activated T cells, and activated B cells. * It is a key inhibitory receptor for activating immune responses. **Pathways and functions:** * KIR2DL1 is a negative regulator of the adaptive immune system. * It interacts with the immune checkpoint molecule PD-1, which is expressed on activated T cells and B cells. * When KIR2DL1 binds to PD-1, it blocks the activation of the T cell or B cell and prevents the initiation of an immune response. * KIR2DL1 is also involved in the regulation of innate immune responses. * It can interact with the complement system and activate a variety of immune cells, including macrophages and dendritic cells. **Clinical significance:** * KIR2DL1 is a potential therapeutic target for cancer immunotherapy. * Inhibition of KIR2DL1 has been shown to enhance the antitumor activity of immune checkpoint blockade therapies. * KIR2DL1 is a promising target for the development of novel immunotherapies for a variety of cancers.

Genular Protein ID: 683940605

Symbol: KI2L1_HUMAN

Name: CD158 antigen-like family member A

UniProtKB Accession Codes:

P43626 O43470 Q32WE6 Q6H2H3 Q6IST4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 66 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7716543

Title: Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells.

PubMed ID: 7716543

DOI: 10.1126/science.7716543

PubMed ID: 7749980

Title: Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains.

PubMed ID: 7749980

DOI: 10.1016/1074-7613(95)90025-x

PubMed ID: 9430221

Title: Human diversity in killer cell inhibitory receptor genes.

PubMed ID: 9430221

DOI: 10.1016/s1074-7613(00)80394-5

PubMed ID: 14607943

Title: Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes.

PubMed ID: 14607943

DOI: 10.4049/jimmunol.171.10.5396

PubMed ID: 23394822

Title: Recombinant structures expand and contract inter and intragenic diversification at the KIR locus.

PubMed ID: 23394822

DOI: 10.1186/1471-2164-14-89

PubMed ID: 24989671

Title: Characterization of a weakly expressed KIR2DL1 variant reveals a novel upstream promoter that controls KIR expression.

PubMed ID: 24989671

DOI: 10.1038/gene.2014.34

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18624290

Title: Evidence that the KIR2DS5 gene codes for a surface receptor triggering natural killer cell function.

PubMed ID: 18624290

DOI: 10.1002/eji.200838434

PubMed ID: 18604210

Title: An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells.

PubMed ID: 18604210

DOI: 10.1038/ni.1635

PubMed ID: 9288975

Title: Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors.

PubMed ID: 9288975

DOI: 10.1038/38028

Sequence Information:

  • Length: 348
  • Mass: 38580
  • Checksum: 24F03F14976614EB
  • Sequence:
    • MSLLVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGRLVK SEETVILQCW SDVMFEHFLL 
HREGMFNDTL RLIGEHHDGV SKANFSISRM TQDLAGTYRC YGSVTHSPYQ VSAPSDPLDI 
VIIGLYEKPS LSAQLGPTVL AGENVTLSCS SRSSYDMYHL SREGEAHERR LPAGPKVNGT 
FQADFPLGPA THGGTYRCFG SFHDSPYEWS KSSDPLLVSV TGNPSNSWPS PTEPSSKTGN 
PRHLHILIGT SVVIILFILL FFLLHRWCSN KKNAAVMDQE SAGNRTANSE DSDEQDPQEV 
TYTQLNHCVF TQRKITRPSQ RPKTPPTDII VYTELPNAES RSKVVSCP

Genular Protein ID: 3389585811

Symbol: Q6H2H2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6H2H2 A0A1W2PPV9

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 39 Ensembl 5 GO 1 Gene3D 1 GenomeRNAi 1 HGNC 1 InterPro 4 KEGG 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 1 PharmGKB 1 Proteomes 2 RefSeq 1 SAM 3 SMART 2 SMR 1 SUPFAM 1 UCSC 1

Citations:

PubMed ID: 14607943

Title: Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes.

PubMed ID: 14607943

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 348
  • Mass: 38534
  • Checksum: 3B4B2C086F63650E
  • Sequence:
    • MSLLVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGRLVK SEETVILQCW SDVMFEHFLL 
HREGMFNDTL RLIGEHHDGV SKANFSISRM TQDLAGTYRC YGSVTHSPYQ VSAPSDPLDI 
VIIGLYEKPS LSAQPGPTVL AGENVTLSCS SRSSYDMYHL SREGEAHERR LPAGTKVNGT 
FQANFPLGPA THGGTYRCFG SFRDSPYEWS KSSDPLLVSV TGNPSNSWPS PTEPSSETGN 
PRHLHILIGT SVVIILFILL FFLLHCWCSN KKNAAVMDQE SAGNRTANSE DSDEQDPQEV 
TYTQLNHCVF TQRKITRPSQ RPKTPPTDII VYTELPNAES RSKVVSCP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.