Details for: MIR200B

Gene ID: 406984

Symbol: MIR200B

Ensembl ID: ENSG00000207730

Description: microRNA 200b

Associated with

  • Pre-notch expression and processing
    (R-HSA-1912422)
  • Pre-notch transcription and translation
    (R-HSA-1912408)
  • Signaling by notch
    (R-HSA-157118)
  • Signal transduction
    (R-HSA-162582)
  • Mirna-mediated gene silencing by inhibition of translation
    (GO:0035278)
  • Mirna-mediated gene silencing by mrna destabilization
    (GO:0035279)
  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna 3'-utr binding
    (GO:0003730)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Negative regulation of angiogenesis
    (GO:0016525)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of blood vessel endothelial cell migration
    (GO:0043537)
  • Negative regulation of cardiac muscle cell differentiation
    (GO:2000726)
  • Negative regulation of cardiac muscle cell proliferation
    (GO:0060044)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of interleukin-33 production
    (GO:0150128)
  • Negative regulation of myotube differentiation
    (GO:0010832)
  • Negative regulation of toll-like receptor 4 signaling pathway
    (GO:0034144)
  • Negative regulation of vascular wound healing
    (GO:0061044)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Regulation of cell cycle
    (GO:0051726)
  • Risc complex
    (GO:0016442)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 2.7277
    Cell Significance Index: 28.2400
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.1500
    Cell Significance Index: 1.3600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0287
    Cell Significance Index: 0.3600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4289
    Cell Significance Index: -7.2100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -1.1570
    Cell Significance Index: -14.0700
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -2.2640
    Cell Significance Index: -25.1800
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -2.4067
    Cell Significance Index: -23.8300
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -2.6093
    Cell Significance Index: -25.7400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -2.8975
    Cell Significance Index: -26.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MIR200B is a 22-nucleotide long microRNA that belongs to the miR-200 family, which is known for its role in regulating epithelial-to-mesenchymal transition (EMT) and maintaining tissue integrity. MIR200B is primarily expressed in epithelial cells, including squamous epithelial cells, acinar cells, and taste receptor cells. Its expression is also found in smooth muscle myoblasts, lymphoid lineage restricted progenitor cells, and pericytes. **Pathways and Functions:** MIR200B regulates various cellular processes through its interactions with multiple target genes and signaling pathways. Some of the key pathways and functions of MIR200B include: * **Negative regulation of angiogenesis**: MIR200B targets genes involved in angiogenesis, thereby inhibiting the formation of new blood vessels. * **Negative regulation of apoptosis**: MIR200B promotes cell survival by inhibiting pro-apoptotic genes. * **Negative regulation of EMT**: MIR200B maintains epithelial integrity by inhibiting EMT-related genes. * **Regulation of cell cycle**: MIR200B targets genes involved in cell cycle regulation, thereby controlling cell proliferation. * **Regulation of Notch signaling**: MIR200B modulates Notch signaling, which is involved in cell differentiation and proliferation. **Clinical Significance:** MIR200B has been implicated in various diseases, including: * **Cancer**: MIR200B is downregulated in several types of cancer, including breast cancer, lung cancer, and colon cancer. Its expression is associated with poor prognosis and metastasis. * **Cardiovascular disease**: MIR200B is involved in the regulation of cardiac muscle cell proliferation and differentiation, making it a potential therapeutic target for cardiovascular diseases. * **Neurological disorders**: MIR200B is expressed in neuronal receptor cells and has been implicated in the regulation of neuronal function and survival. In conclusion, MIR200B is a complex microRNA that plays a multifaceted role in regulating various cellular processes. Its dysregulation has been implicated in several diseases, highlighting the need for further research into its clinical significance and potential therapeutic applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.