Details for: MIR95

Gene ID: 407052

Symbol: MIR95

Ensembl ID: ENSG00000207807

Description: microRNA 95

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0566
    Cell Significance Index: 1.5200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0013
    Cell Significance Index: -0.0100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0016
    Cell Significance Index: -0.0200
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0024
    Cell Significance Index: -0.0200
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.0136
    Cell Significance Index: -0.1500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0151
    Cell Significance Index: -0.1900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0225
    Cell Significance Index: -0.4900
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0318
    Cell Significance Index: -0.3600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0334
    Cell Significance Index: -0.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MIR95 is a 22-nucleotide long, single-stranded RNA that is highly conserved across species. It is encoded by the MIR95 gene, which is located on chromosome 10q23.3 in humans. MIR95 is expressed in various cell types, including neuronal receptor cells, smooth muscle myoblasts, pericytes, lymphoid lineage-restricted progenitor cells, cardiac endothelial cells, plasma cells, cardiac muscle myoblasts, immature innate lymphoid cells, fibroblasts of cardiac tissue, and Purkinje cells. The expression of MIR95 is tightly regulated, with its levels varying across different cell types and developmental stages. **Pathways and Functions:** MIR95 has been implicated in several signaling pathways, including the cellular response to amino acid stimulus, long-term synaptic potentiation, and response to bacterium. These pathways highlight the importance of MIR95 in regulating cellular responses to environmental stimuli, including nutrient availability, synaptic activity, and bacterial infections. MIR95 has been shown to modulate the expression of genes involved in these pathways, influencing cell proliferation, differentiation, and survival. For example, MIR95 has been shown to regulate the expression of genes involved in the cellular response to amino acid stimulus, including the insulin-like growth factor 1 (IGF-1) signaling pathway. **Functions:** The primary function of MIR95 is to regulate gene expression by binding to complementary sequences on target messenger RNA (mRNA) molecules. This binding causes the degradation of mRNA or inhibition of its translation, resulting in a decrease in protein expression. MIR95 has been shown to regulate a wide range of cellular processes, including: 1. Immune regulation: MIR95 has been implicated in regulating the expression of genes involved in immune responses, including the activation of immune cells and the production of cytokines. 2. Cell proliferation and differentiation: MIR95 has been shown to regulate the expression of genes involved in cell proliferation and differentiation, including the regulation of cell cycle progression and the specification of cell fate. 3. Synaptic plasticity: MIR95 has been implicated in regulating the expression of genes involved in synaptic plasticity, including the regulation of neurotransmitter release and synaptic transmission. 4. Cardiovascular homeostasis: MIR95 has been shown to regulate the expression of genes involved in cardiovascular homeostasis, including the regulation of blood pressure and cardiac function. **Clinical Significance:** Dysregulation of MIR95 expression has been implicated in various diseases, including cancer, autoimmune disorders, and cardiovascular disease. For example, alterations in MIR95 expression have been observed in cancer cells, where it can promote tumorigenesis and metastasis. Similarly, dysregulation of MIR95 expression has been implicated in autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis, where it can contribute to immune dysregulation and tissue damage. Furthermore, MIR95 has been shown to play a role in cardiovascular disease, where it can regulate the expression of genes involved in cardiac function and blood pressure regulation. In conclusion, MIR95 is a critical regulator of gene expression, playing a key role in maintaining immune homeostasis and cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms of MIR95 regulation and its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.