Details for: FER1L6 AS1

Gene ID: 439941

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: FER1L6 AS1

Ensembl ID: ENSG00000181171

Description: FER1L6 antisense RNA 1

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 1.11
    rCSI 4.2%
    PRS 99.88

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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  • Node Color (Target Cell CSI, relative to current network):
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    • High
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    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [FER1L6 AS1](/details-gene/439941) is a non-coding RNA (ncRNA) located on chromosome 8q24.13. Based on expression data, this gene shows a significant association with a specific neuronal subtype, the [near-projecting glutamatergic cortical neuron](/details-cell/CL4023012). As an antisense transcript, its primary function is likely regulatory, potentially modulating the expression of its sense-strand counterpart or other genes involved in neuronal identity and function. ## Cellular Roles and Expression Landscape The expression profile of [FER1L6 AS1](/details-gene/439941) points towards a highly specialized role within the central nervous system. * **Primary Cellular Context:** **Overall**, the most significant expression is observed in [near-projecting glutamatergic cortical neurons](/details-cell/CL4023012) (CSI: 1.11). This suggests that [FER1L6 AS1](/details-gene/439941) may be integral to establishing or maintaining the unique functional identity of this specific neuronal population. The data does not provide information on its expression in other cell types, which limits a broader characterization but reinforces its potential as a specific marker for this cortical neuron subtype. ## Pathways and Molecular Function The specific molecular functions and biological pathways involving [FER1L6 AS1](/details-gene/439941) are not well-defined by the provided annotation data. As a long non-coding RNA designated as an antisense transcript, it is hypothesized to function through RNA-RNA interactions, potentially regulating the stability, splicing, or translation of the sense FER1L6 transcript. Its specific expression in glutamatergic neurons suggests a potential role in processes critical to neuronal function, such as synaptic transmission, axon guidance, or gene expression programs that define cortical neuron subtypes. ## Research Directions The specific expression of [FER1L6 AS1](/details-gene/439941) in a distinct neuronal subtype opens up several avenues for future investigation. **Testable Hypotheses:** 1. [FER1L6 AS1](/details-gene/439941) functions as a negative regulator of its sense-strand counterpart, FER1L6, thereby fine-tuning protein levels essential for the proper function or development of [near-projecting glutamatergic cortical neurons](/details-cell/CL4023012). 2. The expression of [FER1L6 AS1](/details-gene/439941) is critical for maintaining the mature transcriptional state of [near-projecting glutamatergic cortical neurons](/details-cell/CL4023012), and its dysregulation could contribute to neurological disorders characterized by cortical neuron dysfunction. **Proposed Experiment:** To test the hypothesis that [FER1L6 AS1](/details-gene/439941) regulates the identity of cortical neurons, a loss-of-function study could be performed. Human induced pluripotent stem cells (iPSCs) could be differentiated into cortical neurons. These neuronal cultures would then be treated with antisense oligonucleotides (ASOs) designed to specifically degrade [FER1L6 AS1](/details-gene/439941) transcripts. The impact of its knockdown would be assessed using single-cell RNA sequencing (scRNA-seq) to determine if the transcriptional identity of the targeted neuronal subtype is altered and to identify downstream gene expression changes, including the expression level of the sense FER1L6 mRNA. **Therapeutic Potential:** Given its status as a non-coding RNA with a highly specific expression pattern, [FER1L6 AS1](/details-gene/439941) could represent a potential therapeutic target for neurological or psychiatric conditions involving the dysfunction of glutamatergic cortical circuits. ASO-based therapies, which can modulate the expression of specific ncRNAs, could be explored to either inhibit or enhance its function. However, its role in any disease pathology must first be established before its therapeutic potential can be seriously considered.