PRKAG3 | ENSG00000115592 | NCBI 53632

Details for: PRKAG3

Gene ID: 53632

Symbol: PRKAG3

Ensembl ID: ENSG00000115592

Description: protein kinase AMP-activated non-catalytic subunit gamma 3

Associated with

Activation of ampk downstream of nmdars
(R-HSA-9619483)
Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Activation of ppargc1a (pgc-1alpha) by phosphorylation
(R-HSA-2151209)
Autophagy
(R-HSA-9612973)
Energy dependent regulation of mtor by lkb1-ampk
(R-HSA-380972)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Lipophagy
(R-HSA-9613354)
Macroautophagy
(R-HSA-1632852)
Membrane trafficking
(R-HSA-199991)
Mitochondrial biogenesis
(R-HSA-1592230)
Mtor signalling
(R-HSA-165159)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Post nmda receptor activation events
(R-HSA-438064)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through phosphorylation
(R-HSA-6804756)
Rna polymerase ii transcription
(R-HSA-73857)
Selective autophagy
(R-HSA-9663891)
Signal transduction
(R-HSA-162582)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by tp53
(R-HSA-3700989)
Translocation of slc2a4 (glut4) to the plasma membrane
(R-HSA-1445148)
Transmission across chemical synapses
(R-HSA-112315)
Vesicle-mediated transport
(R-HSA-5653656)
Amp-activated protein kinase activity
(GO:0004679)
Amp binding
(GO:0016208)
Atp binding
(GO:0005524)
Cellular response to nutrient levels
(GO:0031669)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Extracellular space
(GO:0005615)
Fatty acid biosynthetic process
(GO:0006633)
Glycogen biosynthetic process
(GO:0005978)
Glycolytic process
(GO:0006096)
Intracellular signal transduction
(GO:0035556)
Nucleoplasm
(GO:0005654)
Nucleotide-activated protein kinase complex
(GO:0031588)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein kinase regulator activity
(GO:0019887)
Protein phosphorylation
(GO:0006468)
Regulation of catalytic activity
(GO:0050790)
Response to muscle activity involved in regulation of muscle adaptation
(GO:0014873)

Other Information

Proteins

5'-AMP-activated protein kinase subunit gamma-3

Genular Protein ID: 4241132382

Symbol: AAKG3_HUMAN

Name: 5'-AMP-activated protein kinase subunit gamma-3

UniProtKB Accession Codes:

Q9UGI9 Q4QQG8 Q4V779 Q9NRL1

Database IDs:

Citations:

PubMed ID: 10698692

Title: Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding.

PubMed ID: 10698692

DOI: 10.1042/bj3460659

PubMed ID: 10818001

Title: A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle.

PubMed ID: 10818001

DOI: 10.1126/science.288.5469.1248

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14722619

Title: CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations.

PubMed ID: 14722619

DOI: 10.1172/jci19874

PubMed ID: 17255938

Title: Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunit.

PubMed ID: 17255938

DOI: 10.1038/sj.emboj.7601542

PubMed ID: 17307971

Title: AMP-activated protein kinase in metabolic control and insulin signaling.

PubMed ID: 17307971

DOI: 10.1161/01.res.0000256090.42690.05

PubMed ID: 17712357

Title: AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.

PubMed ID: 17712357

DOI: 10.1038/nrm2249

PubMed ID: 21460634

Title: Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.

PubMed ID: 21460634

DOI: 10.4161/auto.7.7.15451

PubMed ID: 24563466

Title: Cross-talk between two essential nutrient-sensitive enzymes: O-GlcNAc transferase (OGT) and AMP-activated protein kinase (AMPK).

PubMed ID: 24563466

DOI: 10.1074/jbc.m113.523068

PubMed ID: 17878938

Title: Gain-of-function R225W mutation in human AMPKgamma(3) causing increased glycogen and decreased triglyceride in skeletal muscle.

PubMed ID: 17878938

DOI: 10.1371/journal.pone.0000903

Sequence Information:

Length: 489
Mass: 54258
Checksum: 0E93E2B5117B328D
Sequence:

MEPGLEHALR RTPSWSSLGG SEHQEMSFLE QENSSSWPSP AVTSSSERIR GKRRAKALRW 
TRQKSVEEGE PPGQGEGPRS RPAAESTGLE ATFPKTTPLA QADPAGVGTP PTGWDCLPSD 
CTASAAGSST DDVELATEFP ATEAWECELE GLLEERPALC LSPQAPFPKL GWDDELRKPG 
AQIYMRFMQE HTCYDAMATS SKLVIFDTML EIKKAFFALV ANGVRAAPLW DSKKQSFVGM 
LTITDFILVL HRYYRSPLVQ IYEIEQHKIE TWREIYLQGC FKPLVSISPN DSLFEAVYTL 
IKNRIHRLPV LDPVSGNVLH ILTHKRLLKF LHIFGSLLPR PSFLYRTIQD LGIGTFRDLA 
VVLETAPILT ALDIFVDRRV SALPVVNECG QVVGLYSRFD VIHLAAQQTY NHLDMSVGEA 
LRQRTLCLEG VLSCQPHESL GEVIDRIARE QVHRLVLVDE TQHLLGVVSL SDILQALVLS 
PAGIDALGA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PRKAG3

Associated with

Other Information

Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. PubMed ID: 10698692

A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle. PubMed ID: 10818001

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations. PubMed ID: 14722619

Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunit. PubMed ID: 17255938

AMP-activated protein kinase in metabolic control and insulin signaling. PubMed ID: 17307971

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. PubMed ID: 17712357

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop. PubMed ID: 21460634

Cross-talk between two essential nutrient-sensitive enzymes: O-GlcNAc transferase (OGT) and AMP-activated protein kinase (AMPK). PubMed ID: 24563466

Gain-of-function R225W mutation in human AMPKgamma(3) causing increased glycogen and decreased triglyceride in skeletal muscle. PubMed ID: 17878938