IL21 | ENSG00000138684 | NCBI 59067

Details for: IL21

Gene ID: 59067

Symbol: IL21

Ensembl ID: ENSG00000138684

Description: interleukin 21

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Immune system
(R-HSA-168256)
Interleukin-2 family signaling
(R-HSA-451927)
Interleukin-21 signaling
(R-HSA-9020958)
Signaling by interleukins
(R-HSA-449147)
Cell maturation
(GO:0048469)
Cellular response to virus
(GO:0098586)
Cytokine activity
(GO:0005125)
Cytokine receptor binding
(GO:0005126)
Defense response to virus
(GO:0051607)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Germinal center b cell differentiation
(GO:0002314)
Interleukin-2 receptor binding
(GO:0005134)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of immunoglobulin production
(GO:0002639)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of interleukin-17 production
(GO:0032740)
Positive regulation of natural killer cell mediated cytotoxicity
(GO:0045954)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of tissue remodeling
(GO:0034105)
Positive regulation of type ii interferon production
(GO:0032729)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Protein binding
(GO:0005515)
Signal transduction
(GO:0007165)
T follicular helper cell differentiation
(GO:0061470)
Tyrosine phosphorylation of stat protein
(GO:0007260)

Other Information

Proteins

Za11

Genular Protein ID: 3434994508

Symbol: IL21_HUMAN

Name: Za11

UniProtKB Accession Codes:

Q9HBE4 A5J0L4

Database IDs:

Citations:

PubMed ID: 11081504

Title: Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function.

PubMed ID: 11081504

DOI: 10.1038/35040504

PubMed ID: 17673207

Title: Cloning and characterization of an isoform of interleukin-21.

PubMed ID: 17673207

DOI: 10.1016/j.febslet.2007.07.034

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15178704

Title: IFN-alpha regulates IL-21 and IL-21R expression in human NK and T cells.

PubMed ID: 15178704

DOI: 10.1189/jlb.1003488

PubMed ID: 15147560

Title: Interleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responses.

PubMed ID: 15147560

DOI: 10.1111/j.1365-2567.2004.01886.x

PubMed ID: 17565991

Title: The existence of multiple conformers of interleukin-21 directs engineering of a superpotent analogue.

PubMed ID: 17565991

DOI: 10.1074/jbc.m701313200

PubMed ID: 22235133

Title: Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R.

PubMed ID: 22235133

DOI: 10.1074/jbc.m111.311084

PubMed ID: 24746753

Title: Early-onset inflammatory bowel disease and common variable immunodeficiency-like disease caused by IL-21 deficiency.

PubMed ID: 24746753

DOI: 10.1016/j.jaci.2014.02.034

Sequence Information:

Length: 162
Mass: 18653
Checksum: 54EFD4EED3AB97FE
Sequence:

MRSSPGNMER IVICLMVIFL GTLVHKSSSQ GQDRHMIRMR QLIDIVDQLK NYVNDLVPEF 
LPAPEDVETN CEWSAFSCFQ KAQLKSANTG NNERIINVSI KKLKRKPPST NAGRRQKHRL 
TCPSCDSYEK KPPKEFLERF KSLLQKMIHQ HLSSRTHGSE DS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: IL21

Associated with

Other Information

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. PubMed ID: 11081504

Cloning and characterization of an isoform of interleukin-21. PubMed ID: 17673207

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

IFN-alpha regulates IL-21 and IL-21R expression in human NK and T cells. PubMed ID: 15178704

Interleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responses. PubMed ID: 15147560

The existence of multiple conformers of interleukin-21 directs engineering of a superpotent analogue. PubMed ID: 17565991

Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R. PubMed ID: 22235133

Early-onset inflammatory bowel disease and common variable immunodeficiency-like disease caused by IL-21 deficiency. PubMed ID: 24746753