Details for: LINC01915

Gene ID: 729950

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: LINC01915

Ensembl ID: ENSG00000265485

Description: long intergenic non-protein coding RNA 1915

Cell Significance Landscape

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 2.4
    rCSI 5.73%
    PRS 99.98
  • diffuse bipolar 4 cell CL4033031
    CSI 1.03
    rCSI 11.77%
    PRS 100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [LINC01915](/details-gene/729950) is a long intergenic non-coding RNA (lncRNA) located on chromosome 18q11.2. As a non-protein coding gene, its function is likely regulatory, operating at the level of transcription or post-transcriptional processing. Expression data suggests a highly specific role within the central nervous system, with significant expression observed in distinct neuronal populations, including cortical and retinal cells. ## Cellular Roles and Expression Landscape The expression profile of [LINC01915](/details-gene/729950) points towards a specialized function in the nervous system. **Overall**, the gene shows its most significant expression in specific neuronal subtypes. * **Primary Expression Contexts:** The highest significance score is observed in [L4 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4030063) (CSI: 2.40), a type of excitatory neuron in the cerebral cortex. This is followed by [diffuse bipolar 4 cell](/details-cell/CL4033031) (CSI: 1.03), a class of interneuron found in the retina. * **Functional Implication:** This restricted expression pattern suggests that [LINC01915](/details-gene/729950) may contribute to the unique identity or function of these specific neuronal circuits, potentially influencing processes like synaptic transmission in the cortex or visual signal processing in the retina. The available data does not provide information on its expression in non-neuronal cell types. ## Pathways and Molecular Function The specific molecular functions and biological pathways involving [LINC01915](/details-gene/729950) are not detailed in the provided annotations. As a lncRNA expressed in neurons, it may be hypothesized to participate in the regulation of gene expression programs critical for neuronal development, differentiation, or synaptic plasticity. Its mechanism could involve acting as a scaffold for protein complexes, a guide for chromatin-modifying enzymes, or a sponge for microRNAs. ## Research Directions Given its highly specific expression pattern in neuronal subtypes, [LINC01915](/details-gene/729950) warrants further investigation as a potential regulator of neuronal identity and function. **Proposed Hypotheses:** 1. [LINC01915](/details-gene/729950) acts as a critical regulator of gene expression programs that define the functional identity and synaptic properties of [L4 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4030063). Its dysregulation could contribute to corticostriatal circuit dysfunction seen in certain neurological disorders. 2. In the retina, [LINC01915](/details-gene/729950) is involved in modulating the specific signaling pathways within [diffuse bipolar 4 cell](/details-cell/CL4033031), thereby influencing the processing of visual information before it reaches the ganglion cells. **Key Experimental Approach:** To test the hypothesis that [LINC01915](/details-gene/729950) is essential for cortical neuron function, one could utilize an *in vitro* model of human induced pluripotent stem cell (iPSC)-derived cortical neurons. Specific knockdown of [LINC01915](/details-gene/729950) using antisense oligonucleotides (ASOs) could be performed, followed by single-cell RNA sequencing (scRNA-seq) to identify downstream transcriptional changes and patch-clamp electrophysiology to assess alterations in synaptic activity and intrinsic firing properties. **Therapeutic Potential:** The therapeutic potential of [LINC01915](/details-gene/729950) is currently speculative. However, its highly specific expression in select neuronal populations makes it an attractive candidate for targeted therapies. If its dysregulation is linked to neurological or ophthalmological diseases, ASO-based therapies designed to either inhibit (if overexpressed) or stabilize (if under-expressed) the lncRNA could offer a precise intervention with potentially fewer off-target effects than targeting broadly expressed proteins.