Details for: ZNF222

Gene ID: 7673

Symbol: ZNF222

Ensembl ID: ENSG00000159885

Description: zinc finger protein 222

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 41.4670
    Cell Significance Index: -6.4500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 24.4438
    Cell Significance Index: -6.2000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.4584
    Cell Significance Index: -6.7300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.2174
    Cell Significance Index: -5.9400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.7258
    Cell Significance Index: -6.8100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.6470
    Cell Significance Index: 27.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1486
    Cell Significance Index: 218.5900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5581
    Cell Significance Index: 11.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5515
    Cell Significance Index: 54.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5492
    Cell Significance Index: 28.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4410
    Cell Significance Index: 398.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3356
    Cell Significance Index: 36.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3300
    Cell Significance Index: 19.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3138
    Cell Significance Index: 19.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2945
    Cell Significance Index: 47.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1583
    Cell Significance Index: 10.9500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1463
    Cell Significance Index: 3.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1295
    Cell Significance Index: 3.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1207
    Cell Significance Index: 14.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1188
    Cell Significance Index: 21.4100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0976
    Cell Significance Index: 1.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0842
    Cell Significance Index: 16.8900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0819
    Cell Significance Index: 1.1500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0723
    Cell Significance Index: 1.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0604
    Cell Significance Index: 21.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0590
    Cell Significance Index: 7.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0402
    Cell Significance Index: 17.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0324
    Cell Significance Index: 17.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0192
    Cell Significance Index: 2.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0191
    Cell Significance Index: 0.5500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0184
    Cell Significance Index: 0.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0164
    Cell Significance Index: 2.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0099
    Cell Significance Index: 0.4600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0079
    Cell Significance Index: 0.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0077
    Cell Significance Index: 0.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0063
    Cell Significance Index: 0.3300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0021
    Cell Significance Index: 0.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0017
    Cell Significance Index: -0.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0026
    Cell Significance Index: -0.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0031
    Cell Significance Index: -0.1100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0036
    Cell Significance Index: -0.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0037
    Cell Significance Index: -0.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0044
    Cell Significance Index: -3.2000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0070
    Cell Significance Index: -5.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0077
    Cell Significance Index: -5.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0084
    Cell Significance Index: -4.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0135
    Cell Significance Index: -6.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0154
    Cell Significance Index: -0.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0187
    Cell Significance Index: -5.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0197
    Cell Significance Index: -0.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0203
    Cell Significance Index: -1.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0222
    Cell Significance Index: -2.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0226
    Cell Significance Index: -2.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0234
    Cell Significance Index: -1.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0266
    Cell Significance Index: -1.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0282
    Cell Significance Index: -4.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0287
    Cell Significance Index: -0.7800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0300
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0301
    Cell Significance Index: -3.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0330
    Cell Significance Index: -6.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0338
    Cell Significance Index: -1.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0351
    Cell Significance Index: -1.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0369
    Cell Significance Index: -7.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0396
    Cell Significance Index: -5.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0421
    Cell Significance Index: -4.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0437
    Cell Significance Index: -1.1700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0506
    Cell Significance Index: -1.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0656
    Cell Significance Index: -2.1000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0658
    Cell Significance Index: -5.2100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0689
    Cell Significance Index: -1.4300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0715
    Cell Significance Index: -1.9100
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0738
    Cell Significance Index: -0.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0817
    Cell Significance Index: -1.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0872
    Cell Significance Index: -2.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0904
    Cell Significance Index: -2.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1065
    Cell Significance Index: -4.7100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1095
    Cell Significance Index: -1.1900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1190
    Cell Significance Index: -4.1700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1198
    Cell Significance Index: -1.1400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1240
    Cell Significance Index: -3.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1250
    Cell Significance Index: -4.7400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1274
    Cell Significance Index: -1.8100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1277
    Cell Significance Index: -1.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1381
    Cell Significance Index: -4.5200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1501
    Cell Significance Index: -4.7800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1623
    Cell Significance Index: -4.7800
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1776
    Cell Significance Index: -0.9300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1805
    Cell Significance Index: -4.3300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1816
    Cell Significance Index: -4.5300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1842
    Cell Significance Index: -5.4100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1850
    Cell Significance Index: -6.7900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1901
    Cell Significance Index: -1.5500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1904
    Cell Significance Index: -8.2800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1907
    Cell Significance Index: -3.8800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1943
    Cell Significance Index: -4.0600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2032
    Cell Significance Index: -4.3900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2083
    Cell Significance Index: -4.4200
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.2095
    Cell Significance Index: -1.5600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2096
    Cell Significance Index: -6.6300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2134
    Cell Significance Index: -4.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc Finger Domain:** ZNF222 possesses a characteristic zinc finger domain, which is a conserved motif that enables the protein to bind to specific DNA sequences, thereby regulating gene expression. 2. **Tissue-Specific Expression:** ZNF222 is highly expressed in gut endothelial cells, GABAergic interneurons, forebrain radial glial cells, and other tissues, indicating its importance in development and tissue homeostasis. 3. **Transcriptional Regulation:** ZNF222 is involved in regulating DNA-templated transcription, metal ion binding, and RNA polymerase II transcription, highlighting its role in transcriptional control. 4. **Cell-Specific Functions:** ZNF222 has distinct functions in various cell types, including absorptive cells, tuft cells of the colon, and intestinal epithelial cells, suggesting its involvement in specific cellular processes. **Pathways and Functions:** 1. **DNA Binding and Transcription Regulation:** ZNF222 interacts with specific DNA sequences, influencing transcriptional regulation and gene expression. 2. **Metal Ion Binding:** The zinc finger domain of ZNF222 enables it to bind metal ions, which is essential for its function in transcriptional regulation. 3. **RNA Polymerase II Transcription:** ZNF222 interacts with RNA polymerase II, a key enzyme in transcriptional regulation, to control gene expression. 4. **Regulation of DNA-Templated Transcription:** ZNF222 regulates DNA-templated transcription, ensuring accurate gene expression and maintaining tissue homeostasis. **Clinical Significance:** 1. **Immune System Dysfunction:** Alterations in ZNF222 expression have been linked to immune system dysfunction, suggesting its potential role in autoimmune diseases and immunodeficiency disorders. 2. **Cancer Development:** Aberrant ZNF222 expression has been observed in various cancers, including colon cancer, highlighting its potential as a biomarker or therapeutic target. 3. **Neurological Disorders:** ZNF222's involvement in GABAergic interneurons and forebrain radial glial cells suggests its potential role in neurological disorders, such as epilepsy and neurodegenerative diseases. 4. **Developmental Disorders:** ZNF222's expression in gut endothelial cells and intestinal epithelial cells implies its importance in developmental processes, potentially linking it to developmental disorders, such as ataxia and intestinal malformations. In conclusion, ZNF222 is a multifaceted gene that plays a crucial role in regulating gene expression, transcriptional control, and immune function. Further research is necessary to fully elucidate its functions and clinical significance, but its involvement in various diseases and disorders highlights its potential as a therapeutic target or biomarker.

Genular Protein ID: 2851989163

Symbol: ZN222_HUMAN

Name: Zinc finger protein 222

UniProtKB Accession Codes:

Q9UK12 G5E9B9 Q8N6G7 Q9P1U5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12743021

Title: Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.

PubMed ID: 12743021

DOI: 10.1101/gr.963903

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 451
  • Mass: 52484
  • Checksum: A54C0DC566138098
  • Sequence:
    • MAKLYEAVTF KDVAVIFTEE ELGLLDPAQR KLYRDVMLEN FRNLLSVGGK IQTEMETVPE 
AGTHEEFSCK QIWEQIASDL TRSQDTTISN SQLFEQDDNP SQIKARLSTV HTREKPFQGE 
NCKQFFSDVS FFDLPQQLYS GEKSHTCDEC GKSFCYISAL HIHQRVHMGV KCYKCDVCGK 
EFSQSSRLQT HQRVHTGEKP FKCEQCGKGF RCRSALKVHC KLHMREKPYN CEKCGKAFMH 
NFQLQKHHRI HTGEKPFKCE ICGKSFCLRS SLNRHCMVHT AEKLYKSEKY GRGFIDRLDL 
HKHQMIHMGQ KPYNCKECGK SFKWSSYLLV HQRVHTGEKP YKCEECGKGY ISKSGLDFHH 
RTHTGERSYN CDNCGKSFRH ASSILNHKKL HCQRKPLKCE DCGKRLVCRS YCKDQQRDHS 
GENPSKCEDC GKRYKRRLNL DIILSLFLND I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.