Details for: LAPTM5

Gene ID: 7805

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: LAPTM5

Ensembl ID: ENSG00000162511

Description: lysosomal protein transmembrane 5

Selected Context(s):  Pons

Cell Significance Landscape

Contexts:

Associated with

  • Activation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0006919)
  • Cytoplasmic vesicle
    (GO:0031410)
  • Cytosol
    (GO:0005829)
  • Defense response to tumor cell
    (GO:0002357)
  • Golgi to lysosome transport
    (GO:0090160)
  • Induction of programmed cell death
    (GO:0012502)
  • Intracellular protein transport
    (GO:0006886)
  • Lysosomal membrane
    (GO:0005765)
  • Lysosome
    (GO:0005764)
  • Negative regulation of autophagic cell death
    (GO:1904093)
  • Negative regulation of b cell activation
    (GO:0050869)
  • Negative regulation of interleukin-2 production
    (GO:0032703)
  • Negative regulation of t cell activation
    (GO:0050868)
  • Negative regulation of t cell receptor signaling pathway
    (GO:0050860)
  • Negative regulation of type ii interferon production
    (GO:0032689)
  • Perinuclear region of cytoplasm
    (GO:0048471)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of cytokine production involved in immune response
    (GO:0002720)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of lysosomal membrane permeability
    (GO:0097214)
  • Positive regulation of macrophage cytokine production
    (GO:0060907)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of non-canonical nf-kappab signal transduction
    (GO:1901224)
  • Positive regulation of protein ubiquitination
    (GO:0031398)
  • Positive regulation of receptor catabolic process
    (GO:2000646)
  • Positive regulation of tumor necrosis factor-mediated signaling pathway
    (GO:1903265)
  • Positive regulation of ubiquitin-dependent protein catabolic process
    (GO:2000060)
  • Protein-containing complex
    (GO:0032991)
  • Protein binding
    (GO:0005515)
  • Protein sequestering activity
    (GO:0140311)
  • Protein targeting to lysosome
    (GO:0006622)
  • Transport vesicle
    (GO:0030133)
  • Ubiquitin protein ligase binding
    (GO:0031625)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • central nervous system macrophage CL0000878
    CSI 71.69
    rCSI 58.92%
    PRS 8.79

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Genular Protein ID: 708116570

Symbol: LAPM5_HUMAN

Name: Lysosomal-associated transmembrane protein 5

UniProtKB Accession Codes:

Q13571 Q13240 Q14698 Q3KP54

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 32 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8661146

Title: LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells.

PubMed ID: 8661146

DOI: 10.1006/geno.1996.0364

PubMed ID: 7788527

Title: Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7788527

DOI: 10.1093/dnares/2.1.37

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 262
  • Mass: 29937
  • Checksum: 64A9B3F09C14FCE7
  • Sequence:
    • MDPRLSTVRQ TCCCFNVRIA TTALAIYHVI MSVLLFIEHS VEVAHGKASC KLSQMGYLRI 
ADLISSFLLI TMLFIISLSL LIGVVKNREK YLLPFLSLQI MDYLLCLLTL LGSYIELPAY 
LKLASRSRAS SSKFPLMTLQ LLDFCLSILT LCSSYMEVPT YLNFKSMNHM NYLPSQEDMP 
HNQFIKMMII FSIAFITVLI FKVYMFKCVW RCYRLIKCMN SVEEKRNSKM LQKVVLPSYE 
EALSLPSKTP EGGPAPPPYS EV