TNFSF18 | ENSG00000120337 | NCBI 8995

Details for: TNFSF18

Gene ID: 8995

Symbol: TNFSF18

Ensembl ID: ENSG00000120337

Description: TNF superfamily member 18

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Immune system
(R-HSA-168256)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Tnfs bind their physiological receptors
(R-HSA-5669034)
Adaptive immune response
(GO:0002250)
Cell-cell signaling
(GO:0007267)
Cell surface
(GO:0009986)
Cytokine activity
(GO:0005125)
Extracellular space
(GO:0005615)
Identical protein binding
(GO:0042802)
Negative regulation of apoptotic process
(GO:0043066)
Plasma membrane
(GO:0005886)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of leukocyte migration
(GO:0002687)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Protein binding
(GO:0005515)
Regulation of t cell proliferation
(GO:0042129)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
T cell proliferation involved in immune response
(GO:0002309)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)
Tumor necrosis factor receptor superfamily binding
(GO:0032813)

Other Information

Proteins

Activation-inducible TNF-related ligand
A0A0U5JXL4_HUMAN

Genular Protein ID: 3929190417

Symbol: TNF18_HUMAN

Name: Activation-inducible TNF-related ligand

UniProtKB Accession Codes:

Q9UNG2 A9IQG8 O95852 Q6ISV1

Database IDs:

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 10074428

Title: Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR.

PubMed ID: 10074428

DOI: 10.1016/s0960-9822(99)80093-1

PubMed ID: 10037686

Title: Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand.

PubMed ID: 10037686

DOI: 10.1074/jbc.274.10.6056

PubMed ID: 17449724

Title: Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells.

PubMed ID: 17449724

DOI: 10.1189/jlb.0906568

PubMed ID: 23892569

Title: Glucocorticoid-induced tumor necrosis factor receptor family-related ligand triggering upregulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 and promotes leukocyte adhesion.

PubMed ID: 23892569

DOI: 10.1124/jpet.113.207605

PubMed ID: 18040044

Title: Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: implications for function.

PubMed ID: 18040044

DOI: 10.1073/pnas.0709264104

Sequence Information:

Length: 177
Mass: 20308
Checksum: 3D78CE6B90F4C9E3
Sequence:

MCLSHLENMP LSHSRTQGAQ RSSWKLWLFC SIVMLLFLCS FSWLIFIFLQ LETAKEPCMA 
KFGPLPSKWQ MASSEPPCVN KVSDWKLEIL QNGLYLIYGQ VAPNANYNDV APFEVRLYKN 
KDMIQTLTNK SKIQNVGGTY ELHVGDTIDL IFNSEHQVLK NNTYWGIILL ANPQFIS

Genular Protein ID: 1884639073

Symbol: A0A0U5JXL4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0U5JXL4

Database IDs:

Citations:

PubMed ID: 26646413

Title: Comparative genomic analysis of eutherian tumor necrosis factor ligand genes.

PubMed ID: 26646413

DOI: 10.1007/s00251-015-0887-5

Title: Eutherian third-party data gene collections.

DOI: 10.1016/j.genrep.2019.100414

Sequence Information:

Length: 199
Mass: 22724
Checksum: C83A94645745DA58
Sequence:

MTLHPSPITC EFLFSTALIS PKMCLSHLEN MPLSHSRTQG AQRSSWKLWL FCSIVMLLFL 
CSFSWLIFIF LQLETAKEPC MAKFGPLPSK WQMASSEPPC VNKVSDWKLE ILQNGLYLIY 
GQVAPNANYN DVAPFEVRLY KNKDMIQTLT NKSKIQNVGG TYELHVGDTI DLIFNSEHQV 
LKNNTYWGII LLANPQFIS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TNFSF18

Associated with

Other Information

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. PubMed ID: 10074428

Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. PubMed ID: 10037686

Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells. PubMed ID: 17449724

Glucocorticoid-induced tumor necrosis factor receptor family-related ligand triggering upregulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 and promotes leukocyte adhesion. PubMed ID: 23892569

Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: implications for function. PubMed ID: 18040044

Comparative genomic analysis of eutherian tumor necrosis factor ligand genes. PubMed ID: 26646413

Eutherian third-party data gene collections.