No CSI details found for gene ID: 9103
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2504388969
Symbol: FCG2C_HUMAN
Name: Low affinity immunoglobulin gamma Fc region receptor II-c
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2531080
Title: Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium.
PubMed ID: 2531080
PubMed ID: 9516136
Title: Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene.
PubMed ID: 9516136
PubMed ID: 8756631
Title: In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation.
PubMed ID: 8756631
PubMed ID: 23744091
Title: Engineered antibody Fc variant with selectively enhanced FcgammaRIIb binding over both FcgammaRIIa(R131) and FcgammaRIIa(H131).
PubMed ID: 23744091
Sequence Information:
- Length: 323
- Mass: 35578
- Checksum: DC4C1A22A0DE4572
- Sequence:
MGILSFLPVL ATESDWADCK SPQPWGHMLL WTAVLFLAPV AGTPAAPPKA VLKLEPQWIN VLQEDSVTLT CRGTHSPESD SIQWFHNGNL IPTHTQPSYR FKANNNDSGE YTCQTGQTSL SDPVHLTVLS EWLVLQTPHL EFQEGETIVL RCHSWKDKPL VKVTFFQNGK SKKFSRSDPN FSIPQANHSH SGDYHCTGNI GYTLYSSKPV TITVQAPSSS PMGIIVAVVT GIAVAAIVAA VVALIYCRKK RISANSTDPV KAAQFEPPGR QMIAIRKRQP EETNNDYETA DGGYMTLNPR APTDDDKNIY LTLPPNDHVN SNN
Details Unavailable
Detailed CSI data for this gene is not available. You will be redirected to a page with all available raw data in 3 seconds.
If you are not redirected automatically, please click here.
{
"geneID": 9103,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AC243971.2"
]
},
"genePos": {
"start": 5001,
"end": 24882
},
"orientation": true,
"symbol": "FCGR2C",
"created": {
"$date": {
"$numberLong": "1738333349794"
}
},
"crossReference": {
"bulk": [
{
"dbName": "MIM",
"value": "612169"
}
]
},
"chrom": {
"pos": "1",
"type": 1,
"loc": "1q23.3"
},
"desc": "Fc gamma receptor IIc (gene\/pseudogene)",
"geneType": 5,
"ontology": [
{
"id": "GO:0004888",
"term": "transmembrane signaling receptor activity",
"pubMed": [
2531080
],
"cat": 0
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
17474147,
17785206
],
"cat": 0
},
{
"id": "GO:0019770",
"term": "IgG receptor activity",
"cat": 0
},
{
"id": "GO:0019864",
"term": "IgG binding",
"cat": 0
},
{
"id": "GO:0001788",
"term": "antibody-dependent cellular cytotoxicity",
"cat": 1
},
{
"id": "GO:0006955",
"term": "immune response",
"pubMed": [
2531080
],
"cat": 1
},
{
"id": "GO:0007166",
"term": "cell surface receptor signaling pathway",
"cat": 1
},
{
"id": "GO:0032760",
"term": "positive regulation of tumor necrosis factor production",
"cat": 1
},
{
"id": "GO:0038094",
"term": "Fc-gamma receptor signaling pathway",
"cat": 1
},
{
"id": "GO:0050766",
"term": "positive regulation of phagocytosis",
"cat": 1
},
{
"id": "GO:0005737",
"term": "cytoplasm",
"cat": 2
},
{
"id": "GO:0009897",
"term": "external side of plasma membrane",
"cat": 2
},
{
"id": "GO:0016020",
"term": "membrane",
"pubMed": [
2531080
],
"cat": 2
}
],
"protein": [
{
"symbol": "FCG2C_HUMAN",
"name": "Low affinity immunoglobulin gamma Fc region receptor II-c",
"accession": [
"P31995",
"O00523",
"O00524",
"O00525"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"EMBL": [
"X17652",
"X17652",
"U90938",
"U90939",
"U90940",
"U90941"
],
"PIR": [
"S06946"
],
"RefSeq": [
"NP_963857.3",
"XP_011507594.1"
],
"PDB": [
"3WJL",
"6YAX"
],
"PDBsum": [
"3WJL",
"6YAX"
],
"AlphaFoldDB": [
"P31995"
],
"SMR": [
"P31995"
],
"BioGRID": [
"114556"
],
"IntAct": [
"P31995"
],
"DrugBank": [
"DB00087",
"DB00112",
"DB00111",
"DB00005",
"DB00028"
],
"GlyCosmos": [
"P31995"
],
"GlyGen": [
"P31995"
],
"iPTMnet": [
"P31995"
],
"PhosphoSitePlus": [
"P31995"
],
"BioMuta": [
"FCGR2C"
],
"DMDM": [
"399478"
],
"jPOST": [
"P31995"
],
"MassIVE": [
"P31995"
],
"PeptideAtlas": [
"P31995"
],
"ProteomicsDB": [
"54825",
"54826",
"54827",
"54828"
],
"Pumba": [
"P31995"
],
"TopDownProteomics": [
"P31995-4"
],
"DNASU": [
"9103"
],
"KEGG": [
"hsa:9103"
],
"AGR": [
"HGNC:15626"
],
"CTD": [
"9103"
],
"DisGeNET": [
"9103"
],
"GeneCards": [
"FCGR2C"
],
"HGNC": [
"HGNC:15626"
],
"MalaCards": [
"FCGR2C"
],
"MIM": [
"612169"
],
"neXtProt": [
"NX_P31995"
],
"Orphanet": [
"3002"
],
"InParanoid": [
"P31995"
],
"PhylomeDB": [
"P31995"
],
"PathwayCommons": [
"P31995"
],
"SignaLink": [
"P31995"
],
"SIGNOR": [
"P31995"
],
"BioGRID-ORCS": [
"2213",
"9103"
],
"EvolutionaryTrace": [
"P31995"
],
"Pharos": [
"P31995"
],
"PRO": [
"PR:P31995"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"P31995"
],
"GO": [
"GO:0005737",
"GO:0009897",
"GO:0016020",
"GO:0019864",
"GO:0019770",
"GO:0004888",
"GO:0001788",
"GO:0007166",
"GO:0006955",
"GO:0050766",
"GO:0032760"
],
"CDD": [
"cd05752",
"cd05753"
],
"Gene3D": [
"2.60.40.10"
],
"InterPro": [
"IPR007110",
"IPR036179",
"IPR013783",
"IPR050488",
"IPR003599",
"IPR003598"
],
"PANTHER": [
"PTHR11481",
"PTHR11481:SF97"
],
"Pfam": [
"PF13895"
],
"SMART": [
"SM00409",
"SM00408"
],
"SUPFAM": [
"SSF48726"
],
"PROSITE": [
"PS50835"
]
},
"citations": [
{
"title": "Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium.",
"pubmedID": "2531080",
"doi": "10.1002\/j.1460-2075.1989.tb08540.x"
},
{
"title": "Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene.",
"pubmedID": "9516136"
},
{
"title": "In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation.",
"pubmedID": "8756631",
"doi": "10.1128\/mcb.16.9.4735"
},
{
"title": "Engineered antibody Fc variant with selectively enhanced FcgammaRIIb binding over both FcgammaRIIa(R131) and FcgammaRIIa(H131).",
"pubmedID": "23744091",
"doi": "10.1093\/protein\/gzt022"
}
],
"sequence": {
"length": 323,
"mass": 35578,
"checksum": "DC4C1A22A0DE4572",
"modified": {
"$date": {
"$numberLong": "741484800000"
}
},
"version": 1,
"sequence": "MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAGTPAAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIVAAVVALIYCRKKRISANSTDPVKAAQFEPPGRQMIAIRKRQPEETNNDYETADGGYMTLNPRAPTDDDKNIYLTLPPNDHVNSNN"
},
"existence": 0,
"relevance": 1,
"proteinID": 2504388969
}
]
}