Details for: ZC3HAV1L

Gene ID: 92092

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ZC3HAV1L

Ensembl ID: ENSG00000146858

Description: ZC3HAV1 like

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • neural progenitor cell CL0011020
    CSI 5.73
    rCSI 25.23%
    PRS 97.49
  • megakaryocyte CL0000556
    CSI 1.25
    rCSI 5.41%
    PRS 99.2

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [ZC3HAV1L](/details-gene/92092), or Zinc finger CCCH-type antiviral protein 1-like, is a protein-coding gene located on human chromosome 7q34 [[Link](https://doi.org/10.1038/nature01782)]. While its function is not well-characterized, its name suggests a potential role in antiviral responses, analogous to its relative ZC3HAV1 (ZAP). Expression data indicates a highly specific role, with a particularly strong and significant presence in [neural progenitor cells](/details-cell/CL0011020) and a more moderate significance in [megakaryocytes](/details-cell/CL0000556). The protein product is localized to the cytosol ([GO:0005829](https://www.ebi.ac.uk/QuickGO/term/GO:0023024)), and its existence has been confirmed through large-scale cDNA and proteomics projects [[Link](https://doi.org/10.1101/gr.2596504), [Link](https://doi.org/10.1186/1752-0509-5-17)]. ## Cellular Roles and Expression Landscape The expression profile of [ZC3HAV1L](/details-gene/92092) suggests a specialized function in distinct developmental and hematopoietic lineages. - **Overall**, the gene exhibits its most profound significance in [neural progenitor cells](/details-cell/CL0011020) (CSI: 5.73), indicating it may serve as a key marker or functional regulator within this population during neurogenesis. - A secondary, though less pronounced, role is suggested in the hematopoietic system, specifically in [megakaryocytes](/details-cell/CL0000556) (CSI: 1.25), the precursor cells to platelets. The highly specific nature of its expression in these unrelated cell types points towards context-dependent functions, potentially in cell fate decisions or specialized cellular processes rather than ubiquitous housekeeping roles. The lack of broad expression suggests its function is tightly regulated and confined to specific cellular contexts. ## Pathways and Molecular Function Functional annotation for [ZC3HAV1L](/details-gene/92092) is currently limited. The protein is known to be located in the **Cytosol** ([GO:0005829](https://www.ebi.ac.uk/QuickGO/term/GO:0005829)), a common site for signaling proteins and regulatory factors. Although not yet functionally validated, its nomenclature as a "Zinc finger CCCH-type antiviral protein 1-like" strongly implies a potential role in host defense mechanisms, particularly in RNA recognition and degradation as part of the innate immune response, similar to ZAP. Its presence has been noted in several phosphoproteomic studies, suggesting its activity may be regulated by phosphorylation [[Link](https://doi.org/10.1073/pnas.0805139105), [Link](https://doi.org/10.1021/ac9004309)]. ## Research Directions The specific expression pattern and suggestive name of [ZC3HAV1L](/details-gene/92092) open several avenues for future investigation. Its high significance in [neural progenitor cells](/details-cell/CL0011020) is particularly intriguing and warrants further exploration. **Proposed Hypotheses:** 1. [ZC3HAV1L](/details-gene/92092) is a critical regulator of neural progenitor cell self-renewal or differentiation. Its high expression may be necessary to maintain the progenitor state or to guide lineage commitment during brain development. 2. Reflecting its name, [ZC3HAV1L](/details-gene/92092) functions as an antiviral factor in specific cell types, possibly by binding to and targeting viral RNA for degradation. Its expression in [megakaryocytes](/details-cell/CL0000556) could represent a cell-intrinsic defense mechanism against viruses known to infect hematopoietic precursors. **Key Experimental Approach:** To test the hypothesis that [ZC3HAV1L](/details-gene/92092) regulates neural progenitor cell fate, a loss-of-function study could be conducted. CRISPR-Cas9-mediated knockout of [ZC3HAV1L](/details-gene/92092) in human induced pluripotent stem cells (iPSCs) followed by directed differentiation into neural progenitors would be a powerful model. The resulting progenitor populations (wild-type vs. knockout) could be assessed for changes in proliferation rates (e.g., Ki67 staining), differentiation capacity into mature neurons and glia (e.g., immunofluorescence for MAP2 and GFAP), and global gene expression profiles via single-cell RNA sequencing to identify altered developmental trajectories. **Therapeutic Potential:** The therapeutic potential of [ZC3HAV1L](/details-gene/92092) is currently speculative and depends heavily on its true biological function. If it is essential for normal neurodevelopment, targeting it would be challenging due to the high risk of severe neurological side effects. Conversely, if its primary role is antiviral, it could represent a potential target for activation. Enhancing its expression or activity could be a novel strategy to boost innate immunity against specific viral pathogens, particularly those that target hematopoietic or neural systems. Further research into its role in disease states, such as neurodevelopmental disorders or viral infections, is required to properly assess its viability as a therapeutic target.

Genular Protein ID: 2452923675

Symbol: ZCCHL_HUMAN

Name: Zinc finger CCCH-type antiviral protein 1-like

UniProtKB Accession Codes:

Q96H79 Q8WUD9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 1 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 300
  • Mass: 32962
  • Checksum: 9F3B6BABA5CA0E3B
  • Sequence:
    • MAEPTVCSFL TKVLCAHGGR MFLKDLRGHV ELSEARLRDV LQRAGPERFL LQEVETQEGL 
GDAEAEAAAG AVGGGGTSAW RVVAVSSVRL CARYQRGECQ ACDQLHFCRR HMLGKCPNRD 
CWSTCTLSHD IHTPVNMQVL KSHGLFGLNE NQLRILLLQN DPCLLPEVCL LYNKGEALYG 
YCNLKDKCNK FHVCKSFVKG ECKLQTCKRS HQLIHAASLK LLQDQGLNIP SVVNFQIIST 
YKHMKLHKML ENTDNSSPST EHSQGLEKQG VHAAGAAEAG PLASVPAQSA KKPCPVSCEK