Details for: ZNF670 ZNF695

Gene ID: 100533111

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: ZNF670 ZNF695

Ensembl ID: ENSG00000135747

Description: ZNF670-ZNF695 readthrough (NMD candidate)

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • progenitor cell CL0011026
    CSI 4.1
    rCSI 8.72%
    PRS 99.93
  • neural progenitor cell CL0011020
    CSI 2.39
    rCSI 10.51%
    PRS 98.86
  • basal cell of epidermis CL0002187
    CSI 2.32
    rCSI 4.12%
    PRS 98.65

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [ZNF670 ZNF695](/details-gene/100533111) is a non-coding RNA (ncRNA) gene located on chromosome 1q44, which is transcribed as a readthrough transcript and is a candidate for nonsense-mediated decay (NMD). **Overall**, expression data reveals a highly specific profile, with its significance being most pronounced in undifferentiated or highly proliferative cell populations. It is a particularly strong marker for [progenitor cell](/details-cell/CL0011026)s and also shows significant expression in [neural progenitor cell](/details-cell/CL0011020)s and the [basal cell of epidermis](/details-cell/CL0002187), suggesting a potential role in maintaining stemness, regulating cell fate decisions, or facilitating tissue regeneration. ## Cellular Roles and Expression Landscape The expression pattern of [ZNF670 ZNF695](/details-gene/100533111) strongly implicates it in the biology of progenitor and stem-like cells. **Overall**, its most significant expression is observed in a general [progenitor cell](/details-cell/CL0011026) population (CSI: 4.10), indicating a fundamental role in primitive cell states. This association is further supported by its notable significance in more specialized progenitor lineages, including [neural progenitor cell](/details-cell/CL0011020) (CSI: 2.39) and the mitotically active [basal cell of epidermis](/details-cell/CL0002187) (CSI: 2.32). The consistent presence in these distinct cell types, which are responsible for generating differentiated progeny in the nervous system and skin respectively, suggests that [ZNF670 ZNF695](/details-gene/100533111) may be part of a core regulatory network governing self-renewal and the initial stages of differentiation. ## Pathways and Molecular Function Specific functional annotations for [ZNF670 ZNF695](/details-gene/100533111) are not well-defined, which is common for less-characterized non-coding RNAs. However, based on its highly specific expression in progenitor populations, its function is likely intertwined with fundamental cellular processes such as cell cycle control, maintenance of pluripotency, or the regulation of key developmental signaling pathways. As an ncRNA, it may function by interacting with chromatin-modifying complexes, scaffolding proteins, or regulating the stability and translation of target mRNAs involved in cell fate determination. ## Research Directions The specific expression of [ZNF670 ZNF695](/details-gene/100533111) in progenitor cells offers a clear path for future investigation, particularly concerning its role in development and disease. **Proposed Hypotheses:** 1. [ZNF670 ZNF695](/details-gene/100533111) functions as a long non-coding RNA that is essential for maintaining the undifferentiated state of progenitor cells. Its downregulation via developmental cues is a necessary step for lineage commitment, and its forced expression in differentiated cells could induce a more plastic, stem-like phenotype. 2. Given its expression in regenerative cell populations, [ZNF670 ZNF695](/details-gene/100533111) may be aberrantly reactivated in cancer, particularly in cancer stem cell populations. This re-expression could contribute to tumor initiation, self-renewal, and resistance to therapy. **Suggested Experimental Approach:** To test the hypothesis that [ZNF670 ZNF695](/details-gene/100533111) is required for maintaining a progenitor state, a loss-of-function study could be conducted in a relevant cell model, such as human neural progenitor cells. Using CRISPR interference (CRISPRi) to specifically repress the transcription of the [ZNF670 ZNF695](/details-gene/100533111) locus, researchers could then assess the consequences on cell identity. A combination of single-cell RNA sequencing (scRNA-seq) to monitor changes in the transcriptome for signs of spontaneous differentiation, and functional assays like neurosphere formation to measure self-renewal capacity, would elucidate its role in preserving the progenitor state. **Therapeutic Potential:** As an ncRNA highly enriched in progenitor cells, [ZNF670 ZNF695](/details-gene/100533111) could represent a novel therapeutic target in oncology. If its role in promoting a stem-like state is confirmed, it would be a candidate for **inhibition** in cancers that rely on a subpopulation of cancer stem cells. Therapeutic modalities such as antisense oligonucleotides (ASOs) could be designed to specifically target and degrade the ncRNA transcript. However, a key challenge would be achieving tumor-specific delivery to avoid disrupting normal tissue homeostasis maintained by healthy progenitor cell populations.