Details for: RNA5SP281

Gene ID: 100873534

Symbol: RNA5SP281

Ensembl ID: ENSG00000252313

Description: RNA, 5S ribosomal pseudogene 281

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1843
    Cell Significance Index: 1.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0194
    Cell Significance Index: 0.5200
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.0164
    Cell Significance Index: 0.2000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0757
    Cell Significance Index: -0.8400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0888
    Cell Significance Index: -1.9500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1613
    Cell Significance Index: -1.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Structure:** The RNA5SP281 gene is a 5S ribosomal pseudogene, located on chromosome 1q42.3. It consists of a single copy of the 5S rRNA gene, which is a component of the 40S ribosomal subunit. 2. **Expression Pattern:** The RNA5SP281 gene is significantly expressed in various cell types within the intestinal epithelium, including enteroendocrine cells, brush cells, intestinal epithelial cells, goblet cells, absorptive cells, and stem cells. Its expression is also observed in abnormal and neoplastic cells, suggesting its potential role in cancer development. 3. **Cellular Context:** The RNA5SP281 gene is predominantly expressed in cells that are involved in the maintenance of intestinal homeostasis, including stem cells, transit amplifying cells, and goblet cells. **Pathways and Functions:** 1. **Ribosome Biogenesis:** The RNA5SP281 gene is involved in the regulation of ribosome biogenesis, which is essential for protein synthesis and cellular proliferation. 2. **Cellular Differentiation:** The RNA5SP281 gene may play a role in the regulation of cellular differentiation, particularly in the development of goblet cells and enteroendocrine cells. 3. **Apoptosis:** The RNA5SP281 gene may also be involved in the regulation of apoptosis, particularly in the context of intestinal epithelial cells. 4. **Cancer Development:** The RNA5SP281 gene's expression in neoplastic cells suggests its potential role in cancer development and progression. **Clinical Significance:** 1. **Intestinal Diseases:** The RNA5SP281 gene's expression profile suggests its involvement in the pathogenesis of intestinal diseases, including inflammatory bowel disease (IBD), cancer, and other gastrointestinal disorders. 2. **Cancer Biomarkers:** The RNA5SP281 gene's expression in neoplastic cells may serve as a potential biomarker for cancer diagnosis and prognosis. 3. **Therapeutic Targets:** The RNA5SP281 gene's involvement in ribosome biogenesis and cellular differentiation suggests its potential as a therapeutic target for the treatment of intestinal diseases. 4. **Gene Therapy:** The RNA5SP281 gene's role in intestinal homeostasis suggests its potential as a gene therapy target for the treatment of intestinal disorders. In conclusion, the RNA5SP281 gene is a critical component of intestinal homeostasis, and its dysregulation may contribute to the development of intestinal diseases. Further studies are necessary to fully elucidate the RNA5SP281 gene's role in intestinal biology and disease pathogenesis.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.