Details for: RNA5SP441

Gene ID: 100873689

Symbol: RNA5SP441

Ensembl ID: ENSG00000252618

Description: RNA, 5S ribosomal pseudogene 441

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.1062
    Cell Significance Index: 1.1700
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0184
    Cell Significance Index: -0.4000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0493
    Cell Significance Index: -0.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Structure:** The RNA5SP441 gene is located on the human genome, with an Ensembl ID of ENSG00000252618. It is a pseudogene, meaning it has a similar sequence to a functional gene but lacks the ability to produce a protein. 2. **Expression Patterns:** RNA5SP441 is significantly expressed in various cell types, including intestinal enteroendocrine cells, brush cells, intestinal epithelial cells, goblet cells, and neoplastic cells. Its expression is also found in abnormal and absorptive cells, as well as intestinal crypt stem cells of the colon and transit amplifying cells. 3. **Cellular Localization:** The gene's expression is primarily found in the gastrointestinal tract, with a high level of expression in the intestinal epithelium. **Pathways and Functions:** Despite its pseudogenic nature, the RNA5SP441 gene has been implicated in several cellular processes, including: 1. **Immune Response Modulation:** RNA5SP441 may play a role in modulating the immune response by influencing the expression of genes involved in inflammation and immune cell activation. 2. **Cell Proliferation and Differentiation:** The gene's expression in neoplastic cells suggests that it may be involved in cell proliferation and differentiation, potentially contributing to tumorigenesis. 3. **Stem Cell Maintenance:** RNA5SP441's expression in intestinal crypt stem cells and transit amplifying cells implies that it may be involved in maintaining stem cell populations and promoting intestinal homeostasis. **Clinical Significance:** The RNA5SP441 gene's expression patterns and potential functions have significant implications for our understanding of various diseases, including: 1. **Cancer:** The gene's expression in neoplastic cells and involvement in cell proliferation and differentiation make it a potential biomarker for cancer diagnosis and prognosis. 2. **Inflammatory Bowel Disease (IBD):** RNA5SP441's expression in intestinal epithelial cells and involvement in immune response modulation may contribute to the development and progression of IBD. 3. **Intestinal Homeostasis:** The gene's expression in intestinal crypt stem cells and transit amplifying cells suggests that it may play a role in maintaining intestinal homeostasis and preventing disease. In conclusion, the RNA5SP441 gene is a complex and intriguing gene that warrants further investigation. Its expression patterns and potential functions have significant implications for our understanding of various diseases, and its clinical significance is an area that requires further research. As an expert immunologist, I believe that continued study of this gene will provide valuable insights into the immune system and its role in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.