Details for: LINC01485

Gene ID: 101928154

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: LINC01485

Ensembl ID: ENSG00000254211

Description: long intergenic non-protein coding RNA 1485

Cell Significance Landscape

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • midzonal region hepatocyte CL0019028
    CSI 4.72
    rCSI 11.08%
    PRS 99.06
  • periportal region hepatocyte CL0019026
    CSI 3.37
    rCSI 13.1%
    PRS 98.98
  • hepatocyte CL0000182
    CSI 3.31
    rCSI 5.93%
    PRS 99.03
  • centrilobular region hepatocyte CL0019029
    CSI 2.88
    rCSI 7.52%
    PRS 98.83

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [LINC01485](/details-gene/101928154) is a long non-coding RNA with a highly specific expression profile. **Overall**, the data strongly indicate that this gene is a significant marker for liver parenchymal cells. Its expression is most pronounced in [hepatocytes](/details-cell/CL0000182), particularly those within the midzonal region of the liver lobule, suggesting a specialized role in hepatic function and potentially in the metabolic zonation of the liver. ## Cellular Roles and Expression Landscape The expression pattern of [LINC01485](/details-gene/101928154) is predominantly and robustly confined to the [hepatocyte](/details-cell/CL0000182) lineage. Analysis of its expression across various cell types reveals it as a top marker for multiple subpopulations of these essential liver cells. The highest significance score (CSI: 4.72) is observed in the [midzonal region hepatocyte](/details-cell/CL0019028), which lies between the periportal and centrilobular zones. Significant expression is also noted in [periportal region hepatocytes](/details-cell/CL0019026) (CSI: 3.37) and [centrilobular region hepatocytes](/details-cell/CL0019029) (CSI: 2.88). This graded expression pattern across the liver lobule suggests that [LINC01485](/details-gene/101928154) may be involved in functions that are spatially organized within the liver's microenvironment, such as specific metabolic or detoxification pathways. The collective data establish [LINC01485](/details-gene/101928154) as a key molecular feature of [hepatocytes](/details-cell/CL0000182). ## Pathways and Molecular Function Based on the provided data, the specific molecular functions and pathways associated with [LINC01485](/details-gene/101928154) are not yet defined. However, its highly specific expression in [hepatocytes](/details-cell/CL0000182) strongly suggests a role in liver-centric biological processes. As a long non-coding RNA, it likely functions as a regulator of gene expression, potentially influencing transcription, RNA stability, or chromatin structure to control metabolic networks, bile acid synthesis, or the response to xenobiotics, which are all key functions of [hepatocytes](/details-cell/CL0000182). ## Research Directions The pronounced and specific expression of [LINC01485](/details-gene/101928154) in [hepatocytes](/details-cell/CL0000182) presents several avenues for future investigation, particularly concerning its role in liver physiology and disease. **Proposed Hypotheses:** 1. Given its high expression, [LINC01485](/details-gene/101928154) may act as a critical regulator of core metabolic functions in [hepatocytes](/details-cell/CL0000182), such as lipid metabolism or gluconeogenesis. Its dysregulation could therefore contribute to metabolic liver diseases like non-alcoholic fatty liver disease (NAFLD). 2. The graded expression of [LINC01485](/details-gene/101928154) across the liver lobule suggests it may be a downstream effector of the signaling pathways (e.g., Wnt/beta-catenin, oxygen gradients) that establish and maintain liver zonation, thereby contributing to the spatial division of metabolic labor within the organ. **Key Experimental Approach:** To test the hypothesis that [LINC01485](/details-gene/101928154) regulates hepatocyte metabolism, a loss-of-function study could be performed. Specifically, one could use antisense oligonucleotides (ASOs) to knock down [LINC01485](/details-gene/101928154) in an in-vitro model of human [hepatocytes](/details-cell/CL0000182), such as iPSC-derived hepatocytes or the HepG2 cell line. The impact of the knockdown would be assessed by RNA-sequencing to identify downstream gene expression changes, combined with functional assays to measure key metabolic activities like fatty acid oxidation, glucose production, and lipid accumulation. **Therapeutic Potential:** As a lncRNA with high liver specificity, [LINC01485](/details-gene/101928154) is a potentially attractive therapeutic target. Its tissue-restricted expression could minimize off-target effects, a critical advantage for any therapeutic strategy. If future studies demonstrate that elevated levels of [LINC01485](/details-gene/101928154) drive the pathology of liver diseases such as hepatocellular carcinoma or fibrosis, it would become a candidate for therapeutic **inhibition** using RNA-targeting modalities like ASOs, which are particularly well-suited for delivery to the liver.