Details for: RNU6 369P

Gene ID: 106479730

Symbol: RNU6 369P

Ensembl ID: ENSG00000199385

Description: RNA, U6 small nuclear 369, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0231
    Cell Significance Index: 0.5100
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.0194
    Cell Significance Index: 0.1800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.0040
    Cell Significance Index: 0.0400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0026
    Cell Significance Index: -0.0300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0134
    Cell Significance Index: -0.1500
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0190
    Cell Significance Index: -0.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-coding RNA pseudogene**: The RNU6 369P gene is a pseudogene, meaning that it does not encode a protein and is not translated into a functional protein. 2. **Widespread expression**: RNU6 369P is significantly expressed in various cell types within the intestinal tissue, including intestinal epithelial cells, enteroendocrine cells, and neoplastic cells. 3. **Cellular localization**: The gene is localized to the nucleus and is involved in the regulation of RNA processing and splicing. 4. **Evolutionary conservation**: The RNU6 369P gene is highly conserved across different species, suggesting that it has been retained in the genome despite its lack of functional protein-coding potential. **Pathways and Functions:** While the precise function of RNU6 369P remains unclear, several pathways and mechanisms have been proposed to explain its widespread expression and potential role in regulating cellular processes: 1. **RNA splicing and processing**: RNU6 369P may play a role in regulating RNA splicing and processing, influencing the production of mature RNA molecules. 2. **Non-coding RNA-mediated regulation**: As a non-coding RNA pseudogene, RNU6 369P may interact with other non-coding RNAs to regulate gene expression and cellular processes. 3. **Epigenetic regulation**: RNU6 369P may also be involved in epigenetic regulation, influencing chromatin structure and gene expression. **Clinical Significance:** The expression of RNU6 369P in various cell types within the intestinal tissue has significant implications for our understanding of intestinal development, homeostasis, and disease: 1. **Intestinal cancer**: The expression of RNU6 369P in neoplastic cells suggests that it may play a role in the development and progression of intestinal cancer. 2. **Gastrointestinal disorders**: The widespread expression of RNU6 369P in intestinal tissues may also be relevant to gastrointestinal disorders, such as inflammatory bowel disease and irritable bowel syndrome. 3. **Developmental biology**: The expression of RNU6 369P in intestinal stem cells and transit amplifying cells suggests that it may play a role in intestinal development and homeostasis. In conclusion, the RNU6 369P gene is a non-coding RNA pseudogene with widespread expression in various cell types within the intestinal tissue. While its precise function remains unclear, its conservation across different species and its involvement in various cellular processes suggest that it may play a significant role in regulating intestinal development, homeostasis, and disease. Further research is needed to elucidate the mechanisms by which RNU6 369P regulates cellular processes and to explore its potential applications in the diagnosis and treatment of gastrointestinal disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.