Details for: CD300LB

Gene ID: 124599

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CD300LB

Ensembl ID: ENSG00000178789

Description: CD300 molecule like family member b

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • myeloid dendritic cell CL0000782
    CSI 3.35
    rCSI 4.85%
    PRS 99.32
  • myeloid leukocyte CL0000766
    CSI 2.37
    rCSI 2.19%
    PRS 97.39

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

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  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [CD300LB](/details-gene/124599) (CD300 molecule like family member b) is a protein-coding gene located on chromosome 17q25.1. It encodes a type I transmembrane protein that functions as an activating receptor within the immunoglobulin superfamily. Primarily expressed on cells of the myeloid lineage, [CD300LB](/details-gene/124599) is a key component of the innate immune system. Its function involves transducing activating signals, likely through association with adaptor proteins like DAP12, which contributes to the regulation of immune responses. Research suggests its involvement in both innate and adaptive immunity, with genetic linkage to inflammatory conditions such as psoriasis [Link](https://doi.org/10.1007/s00439-002-0851-y). ## Cellular Roles and Expression Landscape **Overall**, the expression profile of [CD300LB](/details-gene/124599) indicates a specialized role within the myeloid compartment of the immune system. Its significance is highest in [myeloid dendritic cell](/details-cell/CL0000782) (CSI: 3.35) and more broadly within the [myeloid leukocyte](/details-cell/CL0000766) population (CSI: 2.37). This highly specific expression pattern suggests that [CD300LB](/details-gene/124599) serves as a key functional marker for these cell types, particularly for dendritic cells, which are critical for initiating and shaping adaptive immune responses. The concentration of its expression in these professional antigen-presenting cells is consistent with its role as an activating receptor involved in immune surveillance and response initiation. ## Pathways and Molecular Function Functionally, [CD300LB](/details-gene/124599) is annotated as a receptor with [transmembrane signaling receptor activity](/details-go/GO0004888) located on the [plasma membrane](/details-go/GO0005886). It participates in the [immune response-activating signaling pathway](/details-go/GO0002757), a role that is central to the [Innate immune system](/details-reactome/R-HSA-168249). Its mechanism of action appears to involve interactions with the signaling adaptor DAP12, as indicated by its inclusion in [Dap12 interactions](/details-reactome/R-HSA-2172127) pathways. This is further supported by studies demonstrating it is an activating receptor capable of signal transduction [Link](https://doi.org/10.4049/jimmunol.177.5.2819). Through its function on myeloid cells, [CD300LB](/details-gene/124599) contributes to [immunoregulatory interactions between a lymphoid and a non-lymphoid cell](/details-reactome/R-HSA-198933), thereby bridging the innate and [Adaptive immune system](/details-reactome/R-HSA-1280218). ## Research Directions The specific role of [CD300LB](/details-gene/124599) as an activating receptor on dendritic cells presents several avenues for future investigation. **Proposed Hypotheses:** 1. Ligation of [CD300LB](/details-gene/124599) on [myeloid dendritic cell](/details-cell/CL0000782) by its endogenous ligand enhances their maturation and antigen-presenting capacity, leading to more robust priming of naive T cells. 2. Given the gene's linkage to psoriasis susceptibility [Link](https://doi.org/10.1007/s00439-002-0851-y), certain genetic variants in [CD300LB](/details-gene/124599) may lead to a lower activation threshold in myeloid cells, contributing to the chronic inflammation characteristic of the disease. 3. The signaling output of [CD300LB](/details-gene/124599) is context-dependent and may be modulated by co-stimulation through other pattern recognition receptors, allowing dendritic cells to fine-tune their response based on the nature of the microbial or danger signal encountered. **Experimental Approach:** To test the first hypothesis—that [CD300LB](/details-gene/124599) engagement promotes dendritic cell function—one could employ an *in vitro* stimulation assay. Primary human monocytes would be differentiated into dendritic cells and then stimulated with a known antigen (e.g., LPS). A subset of these cells would be co-treated with an agonistic monoclonal antibody designed to cross-link and activate [CD300LB](/details-gene/124599). The impact on dendritic cell maturation and function would be quantified by measuring the surface expression of co-stimulatory molecules (CD80, CD86) via flow cytometry, secretion of key cytokines (IL-12p70, TNF-α) by ELISA, and the capacity of these dendritic cells to induce proliferation in a co-culture with allogeneic naive T cells. **Therapeutic Potential:** The function of [CD300LB](/details-gene/124599) as an activating immune receptor presents a dual therapeutic opportunity. In immuno-oncology, an agonistic antibody targeting [CD300LB](/details-gene/124599) could be developed to enhance dendritic cell-mediated anti-tumor immunity, potentially acting synergistically with checkpoint inhibitors. Conversely, in the context of autoimmune or inflammatory diseases like psoriasis where excessive myeloid cell activation is pathogenic, a blocking antibody or small molecule inhibitor targeting [CD300LB](/details-gene/124599) could serve as a therapeutic strategy to dampen the inflammatory response. Its specific expression on myeloid cells may offer a targeted approach with fewer off-target effects compared to broader immunosuppressants.

Genular Protein ID: 110789237

Symbol: CLM7_HUMAN

Name: CMRF35-like molecule 7

UniProtKB Accession Codes:

A8K4G0 Q1EG73 Q8IX40 Q8N6D1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16920917

Title: Molecular and functional characterization of CD300b, a new activating immunoglobulin receptor able to transduce signals through two different pathways.

PubMed ID: 16920917

DOI: 10.4049/jimmunol.177.5.2819

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12483297

Title: Novel immunoglobulin superfamily gene cluster, mapping to a region of human chromosome 17q25, linked to psoriasis susceptibility.

PubMed ID: 12483297

DOI: 10.1007/s00439-002-0851-y

PubMed ID: 17928527

Title: Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells.

PubMed ID: 17928527

DOI: 10.1182/blood-2007-04-085787

Sequence Information:

  • Length: 201
  • Mass: 22689
  • Checksum: 2B8027A488B97CAF
  • Sequence:
    • MWLPPALLLL SLSGCFSIQG PESVRAPEQG SLTVQCHYKQ GWETYIKWWC RGVRWDTCKI 
LIETRGSEQG EKSDRVSIKD NQKDRTFTVT MEGLRRDDAD VYWCGIERRG PDLGTQVKVI 
VDPEGAASTT ASSPTNSNMA VFIGSHKRNH YMLLVFVKVP ILLILVTAIL WLKGSQRVPE 
EPGEQPIYMN FSEPLTKDMA T