Details for: ZNF57

Gene ID: 126295

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ZNF57

Ensembl ID: ENSG00000171970

Description: zinc finger protein 57

Cell Significance Landscape

Associated with

  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • keratinocyte CL0000312
    CSI 3.7
    rCSI 3.11%
    PRS 99.18
  • basal cell CL0000646
    CSI 2.39
    rCSI 3.19%
    PRS 99.74

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [ZNF57](/details-gene/126295) is a protein-coding gene located on chromosome 19p13.3 that encodes Zinc finger protein 57. Based on its functional annotations, [ZNF57](/details-gene/126295) operates as a DNA-binding transcription factor localized within the [nucleus](/details-cell/GO:0005634), where it is involved in the regulation of transcription by RNA polymerase II. **Overall** expression analysis reveals that [ZNF57](/details-gene/126295) shows significant expression enrichment in epidermal cells, particularly [keratinocytes](/details-cell/CL0000312) and [basal cells](/details-cell/CL0000646), suggesting a specialized role in skin biology, potentially related to epidermal maintenance, differentiation, or homeostasis. ## Cellular Roles and Expression Landscape The expression profile of [ZNF57](/details-gene/126295) points to a highly specific function within the integumentary system. **Overall**, the gene's significance is highest in [keratinocytes](/details-cell/CL0000312) (CSI: 3.70) and their progenitors, [basal cells](/details-cell/CL0000646) (CSI: 2.39). These cell types are the primary constituents of the epidermis, responsible for forming the protective outer layer of the skin. The strong and specific expression in these cells suggests that [ZNF57](/details-gene/126295) may function as a key transcriptional regulator governing the identity and function of epidermal cells. Its role could be integral to the complex processes of keratinocyte proliferation, stratification, and terminal differentiation that are essential for maintaining skin barrier integrity. ## Pathways and Molecular Function Functionally, [ZNF57](/details-gene/126295) is annotated as a transcription factor with sequence-specific DNA binding capabilities. Its molecular functions include [DNA-binding transcription factor activity, RNA polymerase II-specific](/details-cell/GO:0000981) and [RNA polymerase II transcription regulatory region sequence-specific DNA binding](/details-cell/GO:0000977). This indicates it directly binds to specific DNA sequences to control the expression of target genes. The protein's involvement in [metal ion binding](/details-cell/GO:0046872) is characteristic of its identity as a zinc finger protein, where zinc ions are crucial for stabilizing its DNA-binding domain. Furthermore, its ability to engage in [protein binding](/details-cell/GO:0005515) suggests it may function as part of a larger multi-protein complex to exert its regulatory effects. Consistent with these roles, it is localized to the [nucleus](/details-cell/GO:0005634). The high expression of this transcription factor in [keratinocytes](/details-cell/CL0000312) suggests its target genes are likely critical for epidermal cell function, as established in several foundational genomic studies ([Link](https://doi.org/10.1038/nature02399), [Link](https://doi.org/10.1038/nature03001)). ## Research Directions The specific enrichment of [ZNF57](/details-gene/126295) in epidermal cells provides a clear basis for investigating its role in both normal skin physiology and cutaneous diseases. **Proposed Hypotheses:** 1. **[ZNF57](/details-gene/126295) is a critical regulator of keratinocyte differentiation.** Given its high expression in both progenitor [basal cells](/details-cell/CL0000646) and their differentiated progeny, [keratinocytes](/details-cell/CL0000312), it is plausible that [ZNF57](/details-gene/126295) modulates the transcriptional programs that drive the transition from proliferation to terminal differentiation in the epidermis. 2. **Dysregulation of [ZNF57](/details-gene/126295) contributes to hyperproliferative skin disorders.** In conditions such as psoriasis or atopic dermatitis, the balance between keratinocyte proliferation and differentiation is disrupted. Aberrant expression or activity of [ZNF57](/details-cell/CL0000312) could be a contributing factor to the pathology of these diseases. 3. **[ZNF57](/details-gene/126295) is involved in the cellular response to epidermal injury and wound healing.** As wound repair requires coordinated keratinocyte proliferation and migration, [ZNF57](/details-gene/126295) may regulate genes essential for these processes. **Experimental Approach:** To test the hypothesis that [ZNF57](/details-gene/126295) is a key regulator of keratinocyte differentiation (Hypothesis 1), a compelling approach would be to utilize an *in vitro* 3D organotypic skin model. Primary human [keratinocytes](/details-cell/CL0000312) could be transduced with lentiviral vectors carrying shRNA or a CRISPRi system to achieve stable knockdown of [ZNF57](/details-gene/126295). These modified cells would then be cultured on a dermal equivalent at an air-liquid interface to induce stratification and differentiation. The resulting tissue structure could be analyzed by histology (H&E staining) to assess epidermal thickness and organization. Furthermore, the expression and localization of key differentiation markers, such as Keratin 1, Keratin 10, Loricrin, and Filaggrin, could be quantified via immunofluorescence and RT-qPCR to determine if the differentiation program has been compromised. **Therapeutic Potential:** As an intracellular transcription factor, [ZNF57](/details-gene/126295) represents a challenging target for conventional small-molecule inhibitors or antibody-based therapies. However, if it is validated as a key driver in skin diseases characterized by keratinocyte hyperproliferation (e.g., psoriasis, certain skin cancers), it could become a candidate for therapeutic intervention using nucleic acid-based strategies. For instance, topically delivered antisense oligonucleotides (ASOs) or siRNA could be designed to specifically reduce [ZNF57](/details-gene/126295) expression in the epidermis. In this context, therapeutic intervention would focus on **inhibition** of its activity to restore normal cellular homeostasis.

Genular Protein ID: 3345721780

Symbol: ZNF57_HUMAN

Name: Zinc finger protein 57

UniProtKB Accession Codes:

Q68EA5 Q8N6R9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 555
  • Mass: 64428
  • Checksum: 295DD933C850397F
  • Sequence:
    • MDSVVFEDVA VDFTLEEWAL LDSAQRDLYR DVMLETFRNL ASVDDGTQFK ANGSVSLQDM 
YGQEKSKEQT IPNFTGNNSC AYTLEKNCEG YGTEDHHKNL RNHMVDRFCT HNEGNQYGEA 
IHQMPDLTLH KKVSAGEKPY ECTKCRTVFT HLSSLKRHVK SHCGRKAPPG EECKQACICP 
SHLHSHGRTD TEEKPYKCQA CGQTFQHPRY LSHHVKTHTA EKTYKCEQCR MAFNGFASFT 
RHVRTHTKDR PYKCQECGRA FIYPSTFQRH MTTHTGEKPY KCQHCGKAFT YPQAFQRHEK 
THTGEKPYEC KQCGKTFSWS ETLRVHMRIH TGDKLYKCEH CGKAFTSSRS FQGHLRTHTG 
EKPYECKQCG KAFTWSSTFR EHVRIHTQEQ LYKCEQCGKA FTSSRSFRGH LRTHTGEKPY 
ECKQCGKTFT WSSTFREHVR IHTQEQLHKC EHCGKAFTSS RAFQGHLRMH TGEKPYECKQ 
CGKTFTWSST LHNHVRMHTG EKPHKCKQCG MSFKWHSSFR NHLRMHTGQK SHECQSYSKA 
FSCQVILSKT SESTH

Genular Protein ID: 465884967

Symbol: B4DXX0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DXX0

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 523
  • Mass: 60716
  • Checksum: 50ED7C959E7F44A1
  • Sequence:
    • MLETFRNLAS VDDGTQFKAN GSVSLQDMYG QEKSKEQTIP NFTGNNSCAY TLEKNCEGYG 
TEDHRKNLRN HMVDRFCTHN EGNQYGEAIH QMPDLTLHKK VSAGEKPYEC TKCRTVFTHL 
SSLKRHVKSH CGRKAPPGEE CKQACICPSH LHSHGRTDTE EKPYKCQACG QTFQHPRYLS 
HHVKTHTAEK TYKCEQCRMA FNGFASFTRH VRTHTKDRPY KCQECGRAFI YPSTFQRHMT 
THTGEKPYKC QHCGKAFTYP QAFQRHEKTH TGEKPYECKQ CGKTFSWSET LRVHMRIHTG 
DKLYKCEHCG KAFTSSRSFQ GHLRTHTGEK PYECKQCGKA FTWSSTFREH VRIHTQEQLY 
KCEQCGKAFT SSRSFRGHLR THTGEKPYEC KQCGKTFTWS STFREHVRIH TQEQLHKCEH 
CGKAFTSSRA FQGHLRMHTG EKPYECKQCG KTFTWSSTLH NHVRMHTGEK PHKCKQCGMS 
FKWHSSFRNH LRMHTGQKSH ECQSYSKAFS CQVILSKTSE STH

Genular Protein ID: 2808687300

Symbol: G3V131_HUMAN

Name: N/A

UniProtKB Accession Codes:

G3V131

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 2 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 523
  • Mass: 60697
  • Checksum: A1A0CBF00F26CFDE
  • Sequence:
    • MLETFRNLAS VDDGTQFKAN GSVSLQDMYG QEKSKEQTIP NFTGNNSCAY TLEKNCEGYG 
TEDHHKNLRN HMVDRFCTHN EGNQYGEAIH QMPDLTLHKK VSAGEKPYEC TKCRTVFTHL 
SSLKRHVKSH CGRKAPPGEE CKQACICPSH LHSHGRTDTE EKPYKCQACG QTFQHPRYLS 
HHVKTHTAEK TYKCEQCRMA FNGFASFTRH VRTHTKDRPY KCQECGRAFI YPSTFQRHMT 
THTGEKPYKC QHCGKAFTYP QAFQRHEKTH TGEKPYECKQ CGKTFSWSET LRVHMRIHTG 
DKLYKCEHCG KAFTSSRSFQ GHLRTHTGEK PYECKQCGKA FTWSSTFREH VRIHTQEQLY 
KCEQCGKAFT SSRSFRGHLR THTGEKPYEC KQCGKTFTWS STFREHVRIH TQEQLHKCEH 
CGKAFTSSRA FQGHLRMHTG EKPYECKQCG KTFTWSSTLH NHVRMHTGEK PHKCKQCGMS 
FKWHSSFRNH LRMHTGQKSH ECQSYSKAFS CQVILSKTSE STH