Details for: OR8G2P

Gene ID: 26492

Symbol: OR8G2P

Ensembl ID: ENSG00000181214

Description: olfactory receptor family 8 subfamily G member 2 pseudogene

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.0383
    Cell Significance Index: 0.4800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0012
    Cell Significance Index: 0.0300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0018
    Cell Significance Index: -0.0200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0021
    Cell Significance Index: -0.0200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0069
    Cell Significance Index: -0.0700
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0082
    Cell Significance Index: -0.0700
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0164
    Cell Significance Index: -0.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR8G2P is a pseudogene, meaning that it has undergone significant degeneration or inactivation, likely due to genetic drift or other mechanisms. Despite its pseudogene status, OR8G2P retains some functional features, including the ability to bind odorants and trigger G protein-coupled receptor activity. This suggests that OR8G2P may retain some residual functionality, albeit at a reduced level compared to its functional counterparts. **Pathways and Functions:** OR8G2P is involved in several key pathways, including: 1. **Detection of chemical stimulus involved in sensory perception of smell**: OR8G2P may play a role in detecting chemical stimuli in the air, which is essential for olfactory perception. 2. **G protein-coupled receptor activity**: OR8G2P is a G protein-coupled receptor, which means that it can interact with G proteins to transmit signals within cells. 3. **G protein-coupled receptor signaling pathway**: OR8G2P is part of the larger G protein-coupled receptor signaling pathway, which is involved in a wide range of cellular processes, including immune response and sensory perception. 4. **Odorant binding**: OR8G2P has been shown to bind odorants, which suggests that it may play a role in the detection of chemical stimuli. 5. **Olfactory receptor activity**: OR8G2P is an olfactory receptor, which means that it is involved in the detection of chemical stimuli in the air. **Clinical Significance:** OR8G2P has implications for our understanding of sensory perception and immune function. While its pseudogene status may limit its functional impact, research suggests that OR8G2P may contribute to: 1. **Sensory perception disorders**: Alterations in OR8G2P expression or function may contribute to sensory perception disorders, such as anosmia (loss of smell) or hyposmia (reduced sense of smell). 2. **Immune system dysfunction**: OR8G2P's expression in immune cells, such as alveolar macrophages, suggests that it may play a role in immune function and response to pathogens. 3. **Cancer research**: OR8G2P's involvement in G protein-coupled receptor signaling pathways may have implications for cancer research, particularly in the context of tumor growth and metastasis. In conclusion, OR8G2P is a pseudogene in the olfactory receptor family that has been implicated in sensory perception and immune function. Further research is needed to fully understand its role in these processes and to explore its potential therapeutic applications.

Database document:

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