Details for: GDF10

Gene ID: 2662

Symbol: GDF10

Ensembl ID: ENSG00000266524

Description: growth differentiation factor 10

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 7.25
    Marker Score: 5800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.19
    Marker Score: 1513
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.47
    Marker Score: 430
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 797
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.97
    Marker Score: 1845.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.97
    Marker Score: 15173
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5346
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.91
    Marker Score: 270
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.89
    Marker Score: 1818.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.86
    Marker Score: 2250
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.77
    Marker Score: 189
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 502
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.63
    Marker Score: 376
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.61
    Marker Score: 938
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 479
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.56
    Marker Score: 385
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 476
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.48
    Marker Score: 201
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.47
    Marker Score: 973
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.46
    Marker Score: 219
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.46
    Marker Score: 246
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.43
    Marker Score: 247
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.43
    Marker Score: 247
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.41
    Marker Score: 259
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.4
    Marker Score: 1149
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.4
    Marker Score: 444
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.38
    Marker Score: 764
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.35
    Marker Score: 544
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.35
    Marker Score: 120
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.34
    Marker Score: 548
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.33
    Marker Score: 354.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.33
    Marker Score: 146
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.32
    Marker Score: 151
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.31
    Marker Score: 326
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.29
    Marker Score: 149
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.27
    Marker Score: 566.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.26
    Marker Score: 3490
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.26
    Marker Score: 248
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.25
    Marker Score: 2397
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.23
    Marker Score: 81
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 117
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.21
    Marker Score: 206
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.21
    Marker Score: 122
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2
    Marker Score: 6852
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.19
    Marker Score: 11916
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.18
    Marker Score: 74
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.18
    Marker Score: 3592
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.18
    Marker Score: 1377
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.17
    Marker Score: 38
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.16
    Marker Score: 6155
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.15
    Marker Score: 928
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.15
    Marker Score: 66
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.14
    Marker Score: 40
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.14
    Marker Score: 329
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.14
    Marker Score: 72
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.14
    Marker Score: 76
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.13
    Marker Score: 70
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.13
    Marker Score: 174
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.13
    Marker Score: 32
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.12
    Marker Score: 315
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.11
    Marker Score: 37
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.1
    Marker Score: 2137
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.1
    Marker Score: 24
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.1
    Marker Score: 24
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.1
    Marker Score: 74
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.09
    Marker Score: 81
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.09
    Marker Score: 26
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.09
    Marker Score: 50
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.09
    Marker Score: 63
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.09
    Marker Score: 55
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.09
    Marker Score: 42
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.09
    Marker Score: 43
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.08
    Marker Score: 331
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.08
    Marker Score: 40
  • Cell Name: S cone cell (CL0003050)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.08
    Marker Score: 98
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.08
    Marker Score: 44
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.08
    Marker Score: 51
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.08
    Marker Score: 19

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Other Information

**Key characteristics:** - GDF10 is a transmembrane protein that belongs to the GDF family of growth factors. - It is highly expressed in the developing cerebral cortex, where it is involved in the specification of neuronal precursors. - GDF10 is also expressed in the bone and cartilage, where it promotes the differentiation of osteoblasts. - It is a key regulator of osteoblast differentiation, and its overexpression leads to the formation of bone tumors. **Pathways and functions:** - GDF10 signaling is involved in multiple pathways, including the transforming growth factor beta receptor signaling pathway, the Wnt/β-catenin signaling pathway, and the bone morphogenetic protein signaling pathway. - It promotes the proliferation and differentiation of neural cells by binding to its receptors, GFRβ and BMP4. - It also inhibits the expression of bone-specific genes, such as osteocalcin and alkaline phosphatase, which are necessary for the differentiation of osteoblasts. **Clinical significance:** - Mutations in the GDF10 gene have been linked to several human diseases, including autism, schizophrenia, and bone disorders. - GDF10 is a promising target for the treatment of these disorders. - Drugs that block GDF10 signaling have been shown to be effective in animal models of these diseases. **Additional information:** - GDF10 is a highly conserved protein, with similar sequences found in mammals, birds, and fish. - It is a secreted protein that acts on a variety of cell types. - It is a key regulator of brain development and function.

Genular Protein ID: 2741352946

Symbol: GDF10_HUMAN

Name: Growth/differentiation factor 10

UniProtKB Accession Codes:

P55107 Q5VSQ8 Q9UCX6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8670277

Title: cDNA cloning and genomic structure of human bone morphogenetic protein-3B (BMP-3b).

PubMed ID: 8670277

DOI: 10.1006/bbrc.1996.0889

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 8679252

Title: Growth/differentiation factor-10: a new member of the transforming growth factor-beta superfamily related to bone morphogenetic protein-3.

PubMed ID: 8679252

DOI: 10.3109/08977199509028956

Sequence Information:

  • Length: 478
  • Mass: 53122
  • Checksum: 80AE0FA4C50B23A9
  • Sequence:
    • MAHVPARTSP GPGPQLLLLL LPLFLLLLRD VAGSHRAPAW SALPAAADGL QGDRDLQRHP 
GDAAATLGPS AQDMVAVHMH RLYEKYSRQG ARPGGGNTVR SFRARLEVVD QKAVYFFNLT 
SMQDSEMILT ATFHFYSEPP RWPRALEVLC KPRAKNASGR PLPLGPPTRQ HLLFRSLSQN 
TATQGLLRGA MALAPPPRGL WQAKDISPIV KAARRDGELL LSAQLDSEER DPGVPRPSPY 
APYILVYAND LAISEPNSVA VTLQRYDPFP AGDPEPRAAP NNSADPRVRR AAQATGPLQD 
NELPGLDERP PRAHAQHFHK HQLWPSPFRA LKPRPGRKDR RKKGQEVFMA ASQVLDFDEK 
TMQKARRKQW DEPRVCSRRY LKVDFADIGW NEWIISPKSF DAYYCAGACE FPMPKIVRPS 
NHATIQSIVR AVGIIPGIPE PCCVPDKMNS LGVLFLDENR NVVLKVYPNM SVDTCACR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.