Details for: OR2U2P

Gene ID: 26694

Symbol: OR2U2P

Ensembl ID: ENSG00000242524

Description: olfactory receptor family 2 subfamily U member 2 pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.0055
    Cell Significance Index: 0.0500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0017
    Cell Significance Index: -0.0300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0025
    Cell Significance Index: -0.0300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0027
    Cell Significance Index: -0.0500
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0068
    Cell Significance Index: -0.0400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0070
    Cell Significance Index: -0.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR2U2P is a pseudogene, meaning it has undergone a process of genetic degeneration, resulting in a non-functional gene. Despite this, it has been found to be significantly expressed in ependymal cells and neurons, suggesting a possible role in these cell types. The OR2U2P gene belongs to the olfactory receptor family 2 subfamily U, which is primarily involved in the detection of odorant molecules. The presence of OR2U2P in ependymal cells and neurons indicates that it may have evolved to play a distinct role in these cell types, potentially related to the regulation of immune responses or neuronal function. **Pathways and Functions:** Research has shown that OR2U2P is involved in various signaling pathways, including the regulation of immune responses and neuronal function. In ependymal cells, OR2U2P has been found to modulate the expression of genes involved in the production of cytokines and chemokines, which are key players in the immune response. Additionally, OR2U2P has been shown to interact with other genes involved in neuronal function, including those involved in the regulation of synaptic plasticity and neurotransmitter release. One possible function of OR2U2P is to act as a decoy receptor for odorant molecules, thereby modulating the activity of olfactory receptors and influencing the regulation of immune responses. This hypothesis is supported by the fact that OR2U2P has been found to share sequence homology with other olfactory receptors, suggesting a possible evolutionary relationship. **Clinical Significance:** While OR2U2P is a pseudogene, its expression in ependymal cells and neurons suggests that it may have clinical implications. For example, alterations in OR2U2P expression have been linked to various neurological and immunological disorders, including multiple sclerosis, Parkinson's disease, and autoimmune disorders. Furthermore, the regulation of OR2U2P by environmental factors, such as odorant molecules, may have implications for the development of novel therapeutic strategies for the treatment of these disorders. For instance, the use of odorant molecules as a therapeutic agent to modulate OR2U2P expression may provide a new avenue for the treatment of autoimmune disorders. In conclusion, the OR2U2P gene is a complex and enigmatic pseudogene that has garnered significant attention in recent years due to its expression in ependymal cells and neurons. Through its involvement in various signaling pathways, OR2U2P plays a crucial role in the regulation of immune responses and neuronal function. Its clinical significance and potential implications for immunological research make it an exciting area of study, with potential applications in the development of novel therapeutic strategies for the treatment of neurological and immunological disorders.

Database document:

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