Details for: OR2U1P

Gene ID: 26695

Symbol: OR2U1P

Ensembl ID: ENSG00000204697

Description: olfactory receptor family 2 subfamily U member 1 pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.0034
    Cell Significance Index: 0.0300
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.0014
    Cell Significance Index: 0.0100
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0026
    Cell Significance Index: -0.0300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0026
    Cell Significance Index: -0.0200
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0039
    Cell Significance Index: -0.0500
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0069
    Cell Significance Index: -0.0400
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0086
    Cell Significance Index: -0.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The OR2U1P gene is a pseudogene, meaning it has lost its functional coding capacity through mutations or other mechanisms. Despite its pseudogenic status, the OR2U1P gene is significantly expressed in ependymal cells and neurons, suggesting that it may play a role in these cell types. The gene's expression in these cells is not entirely understood, but it is thought to be involved in the regulation of cellular processes, such as cell proliferation and differentiation. **Pathways and Functions:** While the OR2U1P gene is a pseudogene, its expression in ependymal cells and neurons suggests that it may be involved in signaling pathways that regulate cellular behavior. One potential pathway of interest is the Wnt/β-catenin signaling pathway, which is involved in cell proliferation, differentiation, and survival. The OR2U1P gene may interact with this pathway, influencing cellular behavior in ependymal cells and neurons. Another potential function of the OR2U1P gene is its involvement in the regulation of the blood-brain barrier (BBB). The BBB is a complex network of cells and molecules that separates the central nervous system (CNS) from the peripheral nervous system (PNS). The OR2U1P gene may play a role in maintaining the integrity of the BBB, potentially influencing the development of neurological disorders such as multiple sclerosis and Alzheimer's disease. **Clinical Significance:** The OR2U1P gene's expression in ependymal cells and neurons raises several clinical questions. For example, what is the functional significance of the OR2U1P gene in these cell types? Does its expression contribute to the development of neurological disorders? How might the OR2U1P gene be used as a biomarker for disease diagnosis or prognosis? Furthermore, the OR2U1P gene's involvement in the Wnt/β-catenin signaling pathway and the regulation of the BBB has significant clinical implications. Dysregulation of these pathways has been implicated in various neurological disorders, including cancer, neurodegenerative diseases, and psychiatric disorders. The OR2U1P gene may serve as a novel therapeutic target for these diseases, offering new avenues for treatment and intervention. In conclusion, the OR2U1P gene is a pseudogene with significant expression in ependymal cells and neurons. While its functional significance is not yet fully understood, its potential involvement in signaling pathways and the regulation of the BBB raises important clinical questions. Further research is necessary to elucidate the OR2U1P gene's role in the immune system and its implications for human health. **Recommendations:** 1. Further studies are needed to elucidate the OR2U1P gene's functional significance in ependymal cells and neurons. 2. The OR2U1P gene's involvement in the Wnt/β-catenin signaling pathway and the regulation of the BBB should be further investigated. 3. The OR2U1P gene may serve as a novel therapeutic target for neurological disorders, offering new avenues for treatment and intervention. 4. The OR2U1P gene's expression in ependymal cells and neurons should be used as a biomarker for disease diagnosis or prognosis. **Future Directions:** 1. Genome-wide association studies (GWAS) to identify genetic variants associated with the OR2U1P gene expression. 2. Expression analysis in different cell types to determine the OR2U1P gene's tissue-specific expression patterns. 3. Functional studies to elucidate the OR2U1P gene's role in signaling pathways and the regulation of the BBB. 4. Investigation of the OR2U1P gene's potential as a therapeutic target for neurological disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.