Details for: SNORD62A

Gene ID: 26786

Symbol: SNORD62A

Ensembl ID: ENSG00000235284

Description: small nucleolar RNA, C/D box 62A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.0798
    Cell Significance Index: 10.2600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0002
    Cell Significance Index: 0.0000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0026
    Cell Significance Index: -0.0300
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0037
    Cell Significance Index: -0.0300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2633
    Cell Significance Index: -2.8200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.8332
    Cell Significance Index: -7.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Small nucleolar RNA (snoRNA) classification**: SNORD62A is a member of the C/D box snoRNA family, which is characterized by their specific secondary structure and the presence of a C/D box motif. 2. **Widespread expression**: SNORD62A is significantly expressed in various cell types, including neuronal receptor cells, smooth muscle myoblasts, cardiac muscle myoblasts, pericytes, lymphoid lineage-restricted progenitor cells, cardiac endothelial cells, immature innate lymphoid cells, fibroblasts of cardiac tissue, and Purkinje cells. 3. **RNA processing regulation**: SNORD62A has been implicated in regulating RNA processing, including pre-rRNA processing and the modification of other RNAs. **Pathways and Functions:** 1. **Nucleolus**: SNORD62A is involved in the regulation of nucleolar function, which is essential for ribosome biogenesis and RNA processing. 2. **RNA processing pathways**: SNORD62A has been shown to interact with other snoRNAs and proteins involved in RNA processing, including the modification of pre-rRNA and the regulation of other RNA molecules. 3. **Cellular differentiation**: SNORD62A plays a role in maintaining cellular homeostasis and regulating cellular differentiation processes, particularly in the development of neuronal and lymphoid cells. 4. **Regulation of gene expression**: SNORD62A may also influence gene expression by regulating the processing and stability of specific mRNAs. **Clinical Significance:** 1. **Diseases associated with SNORD62A dysregulation**: Alterations in SNORD62A expression have been linked to various diseases, including cancer, cardiovascular disease, and neurological disorders. 2. **Therapeutic potential**: Understanding the role of SNORD62A in RNA processing and cellular differentiation may provide new avenues for therapeutic intervention in diseases associated with its dysregulation. 3. **Diagnostic markers**: SNORD62A expression levels may serve as diagnostic markers for certain diseases, particularly those associated with cellular differentiation and RNA processing dysregulation. 4. **Investigating SNORD62A's role in disease**: Further studies are needed to elucidate the mechanisms by which SNORD62A regulates RNA processing and cellular differentiation, and to explore its potential as a therapeutic target or diagnostic marker. In conclusion, SNORD62A is a small nucleolar RNA that plays a critical role in regulating RNA processing and maintaining cellular homeostasis. Its widespread expression across various cell types and its involvement in cellular differentiation processes highlight its potential importance in various diseases. Further research is necessary to fully understand the mechanisms by which SNORD62A regulates RNA processing and cellular differentiation, and to explore its therapeutic potential.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.