Details for: IGHVIII 13 1

Gene ID: 28351

Symbol: IGHVIII 13 1

Ensembl ID: ENSG00000253412

Description: immunoglobulin heavy variable (III)-13-1 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 8

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status**: IGHVIII 13 1 is classified as a pseudogene, which implies that it has undergone genetic degeneration, leading to a loss of its original function. Pseudogenes often retain remnants of their ancestral gene structure but fail to produce a functional protein. 2. **Immunoglobulin heavy chain**: IGHVIII 13 1 belongs to the heavy chain region of the immunoglobulin (Ig) gene family, which plays a crucial role in the adaptive immune response. The heavy chain determines the class and subclass of the antibody produced. 3. **Variable region III**: The IGHVIII 13 1 gene is part of the variable region III (VIII) of the heavy chain. This region is responsible for recognizing and binding to specific antigens, thereby initiating an immune response. 4. **Expression in distinct cell types**: IGHVIII 13 1 is expressed in erythrocytes, double-negative thymocytes, megakaryocytes, and specific neurons, highlighting its unique expression pattern and potential involvement in various cellular processes. **Pathways and Functions:** 1. **Immune response regulation**: Although IGHVIII 13 1 is a pseudogene, its expression in immune cells suggests that it may play a role in regulating immune responses. The gene's presence in erythrocytes and double-negative thymocytes implies that it may influence the development and function of these cells. 2. **Cellular differentiation**: IGHVIII 13 1 expression in megakaryocytes and specific neurons may be involved in cellular differentiation processes. The gene's presence in these cell types could contribute to the regulation of their development and maturation. 3. **Antigen recognition**: Although IGHVIII 13 1 is a pseudogene, its association with the heavy chain region of the Ig gene family suggests that it may still play a role in antigen recognition. The gene's expression in immune cells may contribute to the regulation of immune responses to specific antigens. **Clinical Significance:** 1. **Immunological disorders**: The IGHVIII 13 1 gene's expression in immune cells and its association with specific cell types raise questions about its potential involvement in immunological disorders. Further research is needed to determine whether this gene contributes to the development of autoimmune diseases or other immunological conditions. 2. **Cancer research**: The IGHVIII 13 1 gene's expression in megakaryocytes and specific neurons may be relevant to cancer research. The gene's presence in these cell types could contribute to the regulation of cellular differentiation and proliferation, potentially leading to the development of cancer. 3. **Neurological disorders**: The IGHVIII 13 1 gene's expression in specific neurons raises questions about its potential involvement in neurological disorders. Further research is needed to determine whether this gene contributes to the development of neurodegenerative diseases or other neurological conditions. In conclusion, the IGHVIII 13 1 gene is a complex and intriguing element within the human genome that warrants further investigation. Its unique expression pattern and association with distinct cell types raise questions about its functional significance and potential role in the regulation of immune responses, cellular differentiation, and antigen recognition. Further research is needed to fully understand the significance of this gene and its potential implications for human health and disease.

Database document:

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