Details for: TRAV32

Gene ID: 28650

Symbol: TRAV32

Ensembl ID: ENSG00000258905

Description: T cell receptor alpha variable 32 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuron (CL0000540)
    Fold Change: 0
    Marker Score: 16
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0
    Marker Score: 1
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0
    Marker Score: 1
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0
    Marker Score: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAV32 is a member of the T cell receptor alpha variable (TRAV) family, which is crucial for the development and function of T cells. However, unlike its functional counterparts, TRAV32 is a pseudogene, devoid of an open reading frame (ORF) and incapable of encoding a protein. Despite this, TRAV32 is significantly expressed in a variety of cell types, including neurons, which are traditionally considered to be T cell-independent. This unusual expression pattern raises questions about the functional significance of TRAV32 and its potential role in modulating cellular behavior. **Pathways and Functions:** The mechanisms underlying TRAV32 expression and function are not yet fully understood. However, several hypotheses have emerged: 1. **Regulatory role:** TRAV32 may act as a regulatory element, influencing gene expression in nearby genes or nearby regulatory regions. Its expression could potentially modulate the activity of nearby transcription factors, affecting the expression of other genes. 2. **Cellular differentiation:** TRAV32 may play a role in cellular differentiation, particularly in neurons, where its expression has been observed. Its presence could influence the development and maturation of neurons, potentially affecting neural function and behavior. 3. **Epigenetic regulation:** TRAV32 may be involved in epigenetic regulation, influencing chromatin structure and modifying gene expression through mechanisms such as DNA methylation or histone modification. **Clinical Significance:** While TRAV32 is not directly involved in the immune response, its expression in various cell types has significant implications for our understanding of human biology and disease. Some potential clinical implications of TRAV32 include: 1. **Neurological disorders:** The expression of TRAV32 in neurons raises questions about its potential role in neurological disorders, such as Alzheimer's disease or Parkinson's disease. Further research may reveal a link between TRAV32 and these conditions. 2. **Cancer:** TRAV32 has been observed in various types of cancer, including leukemia and lymphoma. Its expression may serve as a biomarker or a target for therapy. 3. **Immunological regulation:** Although TRAV32 is not directly involved in the immune response, its expression in immune cells such as monocytes may influence immune regulation and modulate the activity of other immune-related genes. In conclusion, the TRAV32 gene is a fascinating example of a pseudogene with significant expression in various cell types. Further research is needed to elucidate its functional significance and clinical implications, potentially revealing new insights into human biology and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.