Details for: TRAJ60

Gene ID: 28695

Symbol: TRAJ60

Ensembl ID: ENSG00000249446

Description: T cell receptor alpha joining 60 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.0048
    Cell Significance Index: 0.0900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0017
    Cell Significance Index: 0.0300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0045
    Cell Significance Index: -0.0600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0052
    Cell Significance Index: -0.1300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0060
    Cell Significance Index: -0.0800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0071
    Cell Significance Index: -0.1200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0160
    Cell Significance Index: -0.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAJ60 is a pseudogene, meaning it lacks a coding sequence and does not produce a functional protein. Despite this, it has been identified as a non-coding RNA (ncRNA) that plays a crucial role in regulating gene expression. Its widespread expression in various cell types, including B cells, innate lymphoid cells, and thymocytes, suggests a conserved function across these cell types. TRAJ60 has been shown to interact with other genes, influencing their expression and thereby modulating immune responses. **Pathways and Functions:** TRAJ60 has been implicated in several key pathways, including: 1. **Regulation of gene expression:** TRAJ60 has been shown to interact with other ncRNAs, influencing their expression and thereby modulating immune responses. It acts as a transcriptional regulator, controlling the expression of genes involved in immune cell development and function. 2. **Cell signaling:** TRAJ60 has been implicated in cell signaling pathways, including the PI3K/AKT and MAPK/ERK pathways. These pathways play critical roles in regulating immune cell development, activation, and function. 3. **Cell differentiation:** TRAJ60 has been shown to influence cell differentiation, particularly in the context of thymocyte development. It regulates the expression of genes involved in thymocyte differentiation, influencing the development of T cells. **Clinical Significance:** The clinical significance of TRAJ60 is an area of active research. While its pseudogene status may seem limiting, its widespread expression and regulatory functions suggest that it plays a crucial role in immune system development and function. Dysregulation of TRAJ60 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases:** TRAJ60 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus. Dysregulation of TRAJ60 has been shown to contribute to the development of autoimmune responses. 2. **Cancer:** TRAJ60 has been implicated in the regulation of cancer cell development and function. Dysregulation of TRAJ60 has been shown to contribute to the development of cancer. 3. **Infectious diseases:** TRAJ60 has been implicated in the regulation of immune responses to infectious diseases. Dysregulation of TRAJ60 has been shown to contribute to the development of infectious diseases. In conclusion, TRAJ60 is a pseudogene with multifaceted roles in the immune system. Its regulatory functions and widespread expression across various cell types suggest a conserved function across these cell types. Further research is needed to fully elucidate the clinical significance of TRAJ60 and its role in immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.