Details for: IGKV1 22

Gene ID: 28936

Symbol: IGKV1 22

Ensembl ID: ENSG00000253578

Description: immunoglobulin kappa variable 1-22 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.0030
    Cell Significance Index: 0.0300
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0094
    Cell Significance Index: -0.0600
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0135
    Cell Significance Index: -0.1300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0135
    Cell Significance Index: -0.1400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0167
    Cell Significance Index: -0.1800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0232
    Cell Significance Index: -0.4700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0255
    Cell Significance Index: -0.3300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0265
    Cell Significance Index: -0.3100
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.0346
    Cell Significance Index: -0.3400
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.0378
    Cell Significance Index: -0.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The IGKV1-22 gene is a pseudogene, which means it lacks a functional promoter, exons, or coding sequence. This leads to the production of a non-functional protein, which is not expected to participate in the immune response or other cellular processes. However, the presence of this pseudogene in various cell types suggests that it may have evolved to play a regulatory role, such as influencing gene expression or cellular differentiation. The high expression levels of IGKV1-22 in certain cell types, including B cells and neurons, highlight the complexity of gene regulation in these cells. **Pathways and Functions** Despite its pseudogenic nature, the IGKV1-22 gene has been implicated in several cellular pathways and functions. For example, its expression in B cells and IgA plasma cells suggests a role in regulating the immune response, possibly by influencing the production of immunoglobulins or other cytokines. Additionally, the presence of IGKV1-22 in neurons and VIP GABAergic cortical interneurons implies a potential role in regulating gene expression or synaptic transmission in the nervous system. The exact mechanisms by which IGKV1-22 regulates these processes are not yet understood, but further research is needed to elucidate its functions. **Clinical Significance** The IGKV1-22 gene's expression in various cell types has significant implications for our understanding of human disease. For example, the presence of IGKV1-22 in B cells and IgA plasma cells may contribute to the development of certain autoimmune disorders, such as multiple sclerosis or rheumatoid arthritis. Similarly, the expression of IGKV1-22 in neurons and VIP GABAergic cortical interneurons may be involved in the pathogenesis of neurological disorders, such as schizophrenia or epilepsy. Further research is needed to determine the clinical significance of IGKV1-22 and its potential role in human disease. In conclusion, the IGKV1-22 gene is a complex pseudogene that plays a regulatory role in various cell types, including B cells, neurons, and monocytes. Its high expression levels and potential involvement in immune responses and neurological disorders make it an important area of research for understanding human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.