Details for: INSL4

Gene ID: 3641

Symbol: INSL4

Ensembl ID: ENSG00000120211

Description: insulin like 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.7
    Marker Score: 8285
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 5.08
    Marker Score: 32717
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6851
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3184
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.95
    Marker Score: 7653
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.34
    Marker Score: 1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7581
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3658
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.1
    Marker Score: 608
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32733
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71840
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48065
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.97
    Marker Score: 566
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5349
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 741
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 404
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.7
    Marker Score: 1322
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.67
    Marker Score: 636
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.54
    Marker Score: 296
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.51
    Marker Score: 1033
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 283
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.46
    Marker Score: 279
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.42
    Marker Score: 137
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.35
    Marker Score: 285
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.33
    Marker Score: 5180
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.27
    Marker Score: 1633
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.25
    Marker Score: 412
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.22
    Marker Score: 105
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.14
    Marker Score: 64
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.09
    Marker Score: 130
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.09
    Marker Score: 54
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.08
    Marker Score: 54
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.08
    Marker Score: 89
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.07
    Marker Score: 73
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.06
    Marker Score: 130
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.06
    Marker Score: 40
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.04
    Marker Score: 119
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.04
    Marker Score: 38
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.03
    Marker Score: 103
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.03
    Marker Score: 42
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.03
    Marker Score: 21.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.03
    Marker Score: 9.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.02
    Marker Score: 117
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.01
    Marker Score: 9.5
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.01
    Marker Score: 130
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.01
    Marker Score: 26
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.01
    Marker Score: 28
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.01
    Marker Score: 22
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.01
    Marker Score: 48
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.01
    Marker Score: 25
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.01
    Marker Score: 380
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.01
    Marker Score: 40
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.01
    Marker Score: 321
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0
    Marker Score: 23
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0
    Marker Score: 10
  • Cell Name: T cell (CL0000084)
    Fold Change: 0
    Marker Score: 8

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Other Information

**Key characteristics:** * INSL4 is a secreted protein that is produced by cells in the body. * It is a member of the insulin-like growth factor (IGF) family of proteins. * INSL4 is expressed in a variety of cell types, including oligodendrocyte precursor cell, progenitor cell, microglial cell, blood vessel endothelial cell, placental villous trophoblast, extravillous trophoblast, neoplastic cell, abnormal cell, erythrocyte, and absorptive cell. **Pathways and functions:** * INSL4 is a signaling molecule that plays a role in cell-cell signaling. * It is involved in the regulation of embryonic development and tissue regeneration. * INSL4 has been shown to promote cell proliferation, migration, and survival. * It also inhibits apoptosis. **Clinical significance:** INSL4 has been implicated in a number of human diseases, including placental abruption, preeclampsia, and cancer. * In placental abruption, INSL4 is produced by the syncytial trophoblast cells of the placenta. * In preeclampsia, INSL4 is produced by the extravillous trophoblast cells of the placenta. * INSL4 is a potential therapeutic target for a number of diseases, including cancer and preeclampsia. **Additional information:** * The gene encoding INSL4 is located on chromosome 17q21.1. * The protein encoded by INSL4 is a transmembrane protein with a molecular weight of approximately 300 kDa. * INSL4 is a highly conserved protein, with a similar sequence found in mammals.

Genular Protein ID: 2028027322

Symbol: INSL4_HUMAN

Name: Early placenta insulin-like peptide

UniProtKB Accession Codes:

Q14641 A8K678 Q5W127

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 6 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 STRING 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8666396

Title: Cloning of a new member of the insulin gene superfamily (INSL4) expressed in human placenta.

PubMed ID: 8666396

DOI: 10.1006/geno.1995.9980

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 9284764

Title: Identification of pro-EPIL and EPIL peptides translated from insulin-like 4 (INSL4) mRNA in human placenta.

PubMed ID: 9284764

DOI: 10.1210/jcem.82.9.4359

PubMed ID: 9740319

Title: Insulin-like 4 (INSL4) gene expression in human embryonic and trophoblastic tissues.

PubMed ID: 9740319

DOI: 10.1002/(sici)1098-2795(199810)51:2<123::aid-mrd1>3.0.co;2-s

PubMed ID: 12414911

Title: Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells.

PubMed ID: 12414911

DOI: 10.1210/jc.2002-021093

Sequence Information:

  • Length: 139
  • Mass: 15445
  • Checksum: 47FB61F6F86C1342
  • Sequence:
    • MASLFRSYLP AIWLLLSQLL RESLAAELRG CGPRFGKHLL SYCPMPEKTF TTTPGGWLLE 
SGRPKEMVST SNNKDGQALG TTSEFIPNLS PELKKPLSEG QPSLKKIILS RKKRSGRHRF 
DPFCCEVICD DGTSVKLCT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.