Details for: MIR128 1

Gene ID: 406915

Symbol: MIR128 1

Ensembl ID: ENSG00000207654

Description: microRNA 128-1

Associated with

  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Cholesterol homeostasis
    (GO:0042632)
  • Extracellular space
    (GO:0005615)
  • Lipid homeostasis
    (GO:0055088)
  • Mirna-mediated gene silencing by inhibition of translation
    (GO:0035278)
  • Mirna-mediated gene silencing by mrna destabilization
    (GO:0035279)
  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna 3'-utr binding
    (GO:0003730)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Negative regulation of brown fat cell differentiation
    (GO:1903444)
  • Negative regulation of cell migration
    (GO:0030336)
  • Negative regulation of cholesterol efflux
    (GO:0090370)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of lipoprotein particle clearance
    (GO:0010985)
  • Negative regulation of lipoprotein transport
    (GO:0140076)
  • Negative regulation of macrophage colony-stimulating factor production
    (GO:1901257)
  • Negative regulation of macrophage migration
    (GO:1905522)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Positive regulation of cell adhesion
    (GO:0045785)
  • Positive regulation of microglial cell activation
    (GO:1903980)
  • Positive regulation of neuroinflammatory response
    (GO:0150078)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Risc complex
    (GO:0016442)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.8112
    Cell Significance Index: 9.4200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0041
    Cell Significance Index: -0.0500
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0068
    Cell Significance Index: -0.0900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0089
    Cell Significance Index: -0.1100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0090
    Cell Significance Index: -0.2000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0103
    Cell Significance Index: -0.1300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0119
    Cell Significance Index: -0.1300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0143
    Cell Significance Index: -0.1500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0387
    Cell Significance Index: -0.4600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.6877
    Cell Significance Index: -6.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **MicroRNA structure:** MIR128-1 is a 22-nucleotide long, single-stranded RNA molecule that is processed from a precursor microRNA (pre-miRNA). 2. **Target recognition:** MIR128-1 recognizes and binds to specific mRNAs, leading to their degradation or translational repression. 3. **Regulatory mechanisms:** MIR128-1 regulates gene expression through two main mechanisms: mRNA degradation and translational repression. 4. **Cellular localization:** MIR128-1 is expressed in various cell types, including immune cells, smooth muscle cells, and epithelial cells. **Pathways and Functions:** 1. **Cellular response to lipopolysaccharide (LPS):** MIR128-1 plays a crucial role in regulating the immune response to LPS by targeting genes involved in inflammation and cytokine production. 2. **Cholesterol homeostasis:** MIR128-1 regulates cholesterol efflux from macrophages by targeting genes involved in lipid metabolism. 3. **Lipid homeostasis:** MIR128-1 modulates lipid metabolism by regulating genes involved in fatty acid synthesis and degradation. 4. **Cell differentiation:** MIR128-1 inhibits brown fat cell differentiation and regulates the expression of genes involved in cell growth and differentiation. 5. **Cell migration:** MIR128-1 regulates cell migration by targeting genes involved in the cytoskeleton and cell adhesion. 6. **Neuroinflammatory response:** MIR128-1 promotes neuroinflammatory response by regulating genes involved in cytokine production and immune cell activation. 7. **RISC complex:** MIR128-1 interacts with the RNA-induced silencing complex (RISC) to regulate gene expression. **Clinical Significance:** 1. **Disease association:** Alterations in MIR128-1 expression have been associated with various diseases, including atherosclerosis, neurodegenerative disorders, and cancer. 2. **Therapeutic potential:** MIR128-1 may serve as a therapeutic target for diseases characterized by dysregulated lipid metabolism, inflammation, and cell differentiation. 3. **Cancer diagnosis:** MIR128-1 may be used as a biomarker for cancer diagnosis and prognosis, as its expression is altered in neoplastic cells. 4. **Immunotherapy:** MIR128-1 may be used as a therapeutic agent to modulate the immune response in diseases characterized by immune dysregulation. In conclusion, MIR128-1 is a critical regulator of immune response, lipid metabolism, and cell differentiation. Its dysregulation has been associated with various diseases, and it may serve as a therapeutic target for the treatment of these diseases. Further research is needed to fully understand the role of MIR128-1 in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.