Details for: RNU2 1

Gene ID: 6066

Symbol: RNU2 1

Ensembl ID: ENSG00000274585

Description: RNA, U2 small nuclear 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.0037
    Cell Significance Index: 0.0300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.0014
    Cell Significance Index: 0.0100
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.0002
    Cell Significance Index: 0.0000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0035
    Cell Significance Index: -0.0500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0038
    Cell Significance Index: -0.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RNU2 is a small nuclear RNA (snRNA) that is part of the U2 snRNP complex, which is a key component in the splicing of pre-mRNA. The U2 snRNP complex recognizes and binds to specific sequences on the pre-mRNA, known as branch points, which are critical for the correct splicing of the RNA transcript. RNU2 is a highly conserved gene, with its sequence showing high similarity across different species, indicating its essential role in the regulation of gene expression. **Pathways and Functions** RNU2 is involved in several key pathways, including: 1. **Gene expression (transcription)**: RNU2 is essential for the regulation of gene expression by ensuring the correct splicing and maturation of RNA transcripts. 2. **Mrna branch site recognition**: RNU2 recognizes and binds to specific sequences on the pre-mRNA, known as branch points, which are critical for the correct splicing of the RNA transcript. 3. **Pre-mrna branch point binding**: RNU2 binds to pre-mRNA branch points, which are essential for the correct splicing of the RNA transcript. 4. **Rna polymerase II transcribes snrna genes**: RNU2 is involved in the transcription of small nuclear RNA (snRNA) genes by RNA polymerase II. 5. **Rna polymerase II transcription**: RNU2 is also involved in the transcription of other genes by RNA polymerase II. **Clinical Significance** The dysregulation of RNU2 has been implicated in various diseases, including: 1. **Neurological disorders**: RNU2 mutations have been associated with neurological disorders, such as frontotemporal dementia and amyotrophic lateral sclerosis (ALS). 2. **Cancer**: RNU2 is overexpressed in some types of cancer, including breast cancer and lung cancer, suggesting its potential role in tumorigenesis. 3. **Cardiovascular disease**: RNU2 is highly expressed in cardiac tissue, and its dysregulation has been implicated in cardiovascular disease, including heart failure and arrhythmias. In conclusion, RNU2 is a critical gene involved in the regulation of gene expression and RNA processing. Its dysregulation has been implicated in various diseases, highlighting its importance as a potential therapeutic target. Further research is needed to fully understand the role of RNU2 in different diseases and to explore its potential as a therapeutic agent.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.