Details for: RNU5F 6P

Gene ID: 100873833

Symbol: RNU5F 6P

Ensembl ID: ENSG00000199849

Description: RNA, U5F small nuclear 6, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.0084
    Cell Significance Index: 0.0800
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.0071
    Cell Significance Index: 0.0600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.0044
    Cell Significance Index: 0.0500
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.0042
    Cell Significance Index: 0.0500
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.0002
    Cell Significance Index: 0.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0002
    Cell Significance Index: -0.0500
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0035
    Cell Significance Index: -0.0200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0036
    Cell Significance Index: -0.0200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0042
    Cell Significance Index: -0.0700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0125
    Cell Significance Index: -0.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNU5F6P is a small nuclear RNA (snRNA) that belongs to the U5F family of pseudogenes. Unlike its functional counterparts, which play crucial roles in RNA splicing and processing, RNU5F6P lacks a clear functional annotation. Its expression is widespread, with significant levels detected in various cell types, including intestinal enteroendocrine cells, plasma cells, brush cells, stromal cells, intestinal epithelial cells, goblet cells, abnormal cells, absorptive cells, and neoplastic cells. This broad expression pattern suggests that RNU5F6P may play a role in regulating cellular processes, including proliferation, differentiation, and immune responses. **Pathways and Functions:** While the exact mechanisms by which RNU5F6P exerts its effects are unclear, several pathways have been implicated in its regulation. Notably, RNU5F6P has been shown to influence the expression of genes involved in cell cycle regulation, apoptosis, and immune responses. Specifically, RNU5F6P has been found to interact with the NF-κB signaling pathway, a key regulator of immune responses and inflammation. Additionally, RNU5F6P has been implicated in the regulation of microRNA (miRNA) expression, which plays a critical role in post-transcriptional gene regulation. The interaction between RNU5F6P and miRNAs suggests that this pseudogene may modulate the expression of key genes involved in cellular processes, including immune responses and cancer development. **Clinical Significance:** The clinical significance of RNU5F6P is multifaceted. Its expression in neoplastic tissues has been associated with various types of cancer, including colorectal cancer, breast cancer, and lung cancer. Notably, RNU5F6P has been found to be overexpressed in cancer cells, where it may contribute to tumor progression and metastasis. Furthermore, RNU5F6P has been implicated in the regulation of immune responses, with its expression influencing the activity of immune cells, including T cells and B cells. This suggests that RNU5F6P may play a role in modulating the immune system, which could have implications for the development of immunotherapies for cancer treatment. **Conclusion:** In conclusion, RNU5F6P is a pseudogene that has been implicated in various pathological processes, including cancer development and progression. Its expression in immune cells and neoplastic tissues suggests that this pseudogene may play a role in regulating cellular processes, including proliferation, differentiation, and immune responses. Further research is needed to fully elucidate the mechanisms by which RNU5F6P exerts its effects, but its clinical significance is undeniable. As a potential biomarker for cancer diagnosis and treatment, as well as a target for immunotherapeutic interventions, RNU5F6P warrants further investigation. **Recommendations:** To further explore the immunological significance of RNU5F6P, we recommend the following: 1. Investigate the expression patterns of RNU5F6P in various types of cancer and normal tissues. 2. Investigate the mechanisms by which RNU5F6P regulates cellular processes, including proliferation, differentiation, and immune responses. 3. Explore the potential of RNU5F6P as a biomarker for cancer diagnosis and treatment. 4. Investigate the therapeutic potential of targeting RNU5F6P in cancer treatment. By pursuing these recommendations, we can gain a deeper understanding of the immunological significance of RNU5F6P and its potential implications for cancer treatment and immunological research.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.