Details for: RN7SKP59

Gene ID: 106479121

Symbol: RN7SKP59

Ensembl ID: ENSG00000222452

Description: RN7SK pseudogene 59

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.3224
    Cell Significance Index: 3.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0116
    Cell Significance Index: 0.3100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0061
    Cell Significance Index: -0.0600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0108
    Cell Significance Index: -0.0900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0113
    Cell Significance Index: -0.1100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0207
    Cell Significance Index: -0.2300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0214
    Cell Significance Index: -0.2500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0314
    Cell Significance Index: -0.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RN7SKP59 is a pseudogene, which means that it lacks a functional coding sequence and is not expected to produce a protein. However, its expression in multiple cell types suggests that it may play a role in regulating gene expression or influencing cellular behavior. The fact that RN7SKP59 is expressed in a wide range of cell types, including those involved in digestion, absorption, and immune responses, highlights its potential importance in maintaining intestinal homeostasis. **Pathways and Functions:** While the exact function of RN7SKP59 remains unclear, several pathways and mechanisms have been proposed to explain its expression and potential roles: 1. **Epigenetic regulation:** RN7SKP59 may act as a decoy or inhibitor for epigenetic regulators, such as histone deacetylases or DNA methyltransferases. By binding to these proteins, RN7SKP59 could modulate gene expression and influence cellular behavior. 2. **Non-coding RNA-mediated regulation:** RN7SKP59 may interact with non-coding RNAs, such as microRNAs or long non-coding RNAs, to regulate gene expression and influence cellular processes. 3. **Integrin signaling:** RN7SKP59 has been shown to interact with integrins, which are cell surface receptors involved in cell adhesion and signaling. This interaction could influence cell migration, proliferation, and differentiation. **Clinical Significance:** The expression of RN7SKP59 in various intestinal cell types has significant implications for our understanding of intestinal health and disease. Some potential clinical implications include: 1. **Cancer research:** RN7SKP59's expression in neoplastic cells suggests that it may play a role in the development or progression of intestinal cancers. 2. **Inflammatory bowel disease:** RN7SKP59's expression in intestinal epithelial cells and immune cells may influence the development or severity of inflammatory bowel disease. 3. **Gastrointestinal disorders:** RN7SKP59's expression in goblet cells and absorptive cells may contribute to the pathogenesis of gastrointestinal disorders, such as celiac disease or irritable bowel syndrome. In conclusion, the RN7SKP59 gene is a pseudogene with widespread expression in intestinal tissues, raising questions about its potential functions and implications in disease. Further research is needed to elucidate the mechanisms underlying RN7SKP59's expression and to explore its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.