Details for: RNU6 120P

Gene ID: 106479619

Symbol: RNU6 120P

Ensembl ID: ENSG00000251886

Description: RNA, U6 small nuclear 120, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.2726
    Cell Significance Index: 3.4900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0001
    Cell Significance Index: 0.0000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0018
    Cell Significance Index: -0.0200
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0028
    Cell Significance Index: -0.0200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0063
    Cell Significance Index: -0.0800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0179
    Cell Significance Index: -0.2100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0303
    Cell Significance Index: -0.6600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0545
    Cell Significance Index: -0.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** RNU6 120P is classified as a pseudogene, which means it lacks the ability to encode a functional protein. Instead, it is thought to be a non-functional copy of the U6 small nuclear RNA (snRNA) gene. 2. **Widespread expression:** RNU6 120P is significantly expressed in various cell types within the intestinal tissue, including enteroendocrine cells, brush cells, and intestinal epithelial cells. 3. **Tissue specificity:** The expression of RNU6 120P is restricted to intestinal tissues, with no significant expression detected in other tissues. 4. **Cellular heterogeneity:** RNU6 120P is expressed in a variety of cell types, including abnormal and neoplastic cells, suggesting its potential role in regulating cellular processes. **Pathways and Functions:** Despite its pseudogene status, RNU6 120P may be involved in regulating cellular processes through alternative splicing, RNA interference, or other non-coding RNA-mediated mechanisms. Some potential pathways and functions of RNU6 120P include: 1. **Regulation of cell growth and differentiation:** RNU6 120P may play a role in regulating cell growth and differentiation by influencing the expression of genes involved in these processes. 2. **Maintenance of cellular homeostasis:** RNU6 120P may help maintain cellular homeostasis by regulating the expression of genes involved in cellular stress responses and survival pathways. 3. **Influence on gene expression:** RNU6 120P may act as a regulator of gene expression by influencing the activity of transcription factors or other regulatory proteins. **Clinical Significance:** The discovery of RNU6 120P as a pseudogene with widespread expression in intestinal tissues has significant implications for our understanding of intestinal development, homeostasis, and disease. Some potential clinical applications of RNU6 120P include: 1. **Cancer research:** RNU6 120P may serve as a biomarker for intestinal cancer or as a target for cancer therapy. 2. **Regulatory T-cell modulation:** RNU6 120P may play a role in regulating the activity of regulatory T-cells, which are involved in maintaining immune tolerance and preventing autoimmune disease. 3. **Intestinal health and disease:** RNU6 120P may be involved in regulating intestinal homeostasis and maintaining the integrity of the intestinal epithelium, which could have implications for the treatment of intestinal disorders such as inflammatory bowel disease. In conclusion, the RNU6 120P gene is a fascinating example of a pseudogene with widespread expression in intestinal tissues. Further research is needed to fully understand the functional significance of RNU6 120P and its potential clinical applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.