Details for: RNU6 470P

Gene ID: 106479773

Symbol: RNU6 470P

Ensembl ID: ENSG00000251763

Description: RNA, U6 small nuclear 470, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1598
    Cell Significance Index: 2.1800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0030
    Cell Significance Index: -0.1900
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1060
    Cell Significance Index: -1.0300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1061
    Cell Significance Index: -1.2600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1209
    Cell Significance Index: -1.2300
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.1253
    Cell Significance Index: -1.5700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1315
    Cell Significance Index: -1.2300
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1355
    Cell Significance Index: -1.8300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1698
    Cell Significance Index: -1.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The RNU6 470P pseudogene is a small nuclear RNA (snRNA) of approximately 470 nucleotides in length. As a pseudogene, it lacks the ability to encode a protein, instead, it may play a regulatory or structural role in the processing of other RNAs. Its significant expression in multiple cell types, including neoplastic cells, suggests that it may be involved in cellular processes such as differentiation, proliferation, or survival. Notably, its expression is also observed in abnormal cells, which may indicate a role in tumorigenesis or cancer progression. **Pathways and Functions:** Despite its pseudogenic nature, the RNU6 470P RNA may be involved in various cellular pathways. Its expression in intestinal epithelial cells and goblet cells suggests a role in the regulation of intestinal homeostasis and the maintenance of the epithelial barrier. In the context of immune responses, the RNU6 470P RNA may interact with other RNAs or proteins involved in the regulation of immune cell function, such as T cells or dendritic cells. Furthermore, its expression in retinal rod cells and neoplastic cells may indicate a role in the regulation of cell growth, differentiation, or survival in these contexts. **Clinical Significance:** The RNU6 470P pseudogene's significant expression in various cell types and its association with neoplastic cells raise important questions about its potential role in human disease. As a biomarker, the RNU6 470P RNA may be useful in the diagnosis or monitoring of cancers, particularly those with intestinal or epithelial origins. Additionally, its involvement in cellular processes such as differentiation and proliferation may make it a valuable target for therapeutic interventions aimed at modulating these processes in disease states. In conclusion, the RNU6 470P pseudogene is a complex and multifaceted molecule that warrants further investigation into its functions and significance in human health and disease. Its significant expression in various cell types and its association with neoplastic cells make it an attractive candidate for further study, with potential implications for cancer diagnosis, therapy, and our understanding of cellular regulation. **Future Directions:** To further elucidate the role of the RNU6 470P pseudogene, future studies should focus on: 1. Investigating the molecular mechanisms underlying its expression and regulation in different cell types. 2. Examining its interactions with other RNAs or proteins involved in cellular processes, such as immune responses or cell growth. 3. Exploring its potential as a biomarker for cancer diagnosis or monitoring. 4. Investigating its role in cellular processes such as differentiation, proliferation, or survival in different contexts. By pursuing these lines of inquiry, we may uncover new insights into the functions and significance of the RNU6 470P pseudogene, ultimately shedding light on its potential role in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.