Details for: FER1L6 AS2

Gene ID: 157376

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: FER1L6 AS2

Ensembl ID: ENSG00000253868

Description: FER1L6 antisense RNA 2

Cell Significance Landscape

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • L6b glutamatergic cortical neuron CL4023038
    CSI 4.45
    rCSI 13.9%
    PRS 99.88
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 4.36
    rCSI 10.6%
    PRS 99.75
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 3.69
    rCSI 13.96%
    PRS 99.8
  • direct pathway medium spiny neuron CL4023026
    CSI 0.68
    rCSI 16.4%
    PRS 99.61

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [FER1L6 AS2](/details-gene/157376) is a non-coding RNA (ncRNA) gene located on human chromosome 8q24.13. Expression data indicates a highly specific role within the central nervous system. Its significance is particularly pronounced in distinct subpopulations of excitatory neurons, most notably glutamatergic cortical neurons, suggesting a potential function in regulating neuronal identity, cortical architecture, or synaptic function within these specific cell types. ## Cellular Roles and Expression Landscape The expression profile of [FER1L6 AS2](/details-gene/157376) points towards a specialized function in the mammalian brain, specifically within excitatory neuronal circuits. * **Primary Expression in Cortical Neurons:** In the **Overall** context, the gene shows its highest significance in several subtypes of glutamatergic neurons within the cerebral cortex. It is a particularly strong marker for [L6b glutamatergic cortical neuron](/details-cell/CL4023038) (CSI: 4.45), [L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040) (CSI: 4.36), and [near-projecting glutamatergic cortical neuron](/details-cell/CL4023012) (CSI: 3.69). This concentrated expression pattern suggests a role in establishing or maintaining the functional identity of these specific cortical layers and projection classes. * **Role in Basal Ganglia:** The gene also shows notable, albeit lower, significance in the [direct pathway medium spiny neuron](/details-cell/CL4023026) (CSI: 0.68). This finding suggests its function may extend beyond the cortex to include the regulation of circuits within the basal ganglia, which are critical for motor control and reward-based learning. ## Pathways and Molecular Function Based on the available annotations, the specific molecular pathways and biological processes involving [FER1L6 AS2](/details-gene/157376) have not yet been fully characterized. As a non-coding RNA, it likely functions through regulatory mechanisms such as guiding chromatin-modifying complexes, acting as a molecular sponge for microRNAs, or modulating the stability and translation of target mRNAs. Its cell-type-specific expression strongly suggests that its regulatory targets are crucial for the development or function of glutamatergic neurons. ## Research Directions The highly specific neuronal expression of [FER1L6 AS2](/details-gene/157376) presents several avenues for future investigation into its role in neural circuit function and its potential contribution to neurological disease. **Proposed Hypotheses:** 1. **Regulation of Cortical Neuron Identity:** Given its high significance in specific cortical glutamatergic neuron subtypes, [FER1L6 AS2](/details-gene/157376) may function as a key regulator of the transcriptional programs that define the identity and connectivity of these neurons during development and maintain their stability in adulthood. 2. **Modulation of Synaptic Function in the Striatum:** Its expression in direct pathway medium spiny neurons suggests [FER1L6 AS2](/details-gene/157376) could be involved in modulating synaptic plasticity or gene expression downstream of dopamine D1 receptor signaling, thereby influencing motor function or reinforcement learning. **Key Experimental Approach:** To test the hypothesis that [FER1L6 AS2](/details-gene/157376) is critical for cortical neuron identity, a loss-of-function study could be performed. Using CRISPR interference (CRISPRi) to specifically knockdown [FER1L6 AS2](/details-gene/157376) in human iPSC-derived cortical organoids, researchers could assess the impact on neuronal development and function. Single-cell RNA sequencing (scRNA-seq) could be used to determine if the knockdown disrupts the proper differentiation or alters the gene expression profiles of L2/3, L6b, and other cortical neuron subtypes. Furthermore, patch-clamp electrophysiology on knockdown neurons would reveal any resulting deficits in firing patterns or synaptic properties. **Therapeutic Potential:** The exquisite cell-type specificity of [FER1L6 AS2](/details-gene/157376) makes it an attractive potential therapeutic target. If dysregulation of this ncRNA is implicated in neurological or psychiatric disorders characterized by cortical dysfunction (e.g., certain forms of epilepsy, schizophrenia, or autism spectrum disorders), it could be targeted with high precision. An antisense oligonucleotide (ASO) therapy designed to either degrade (in case of gain-of-function) or stabilize (in case of loss-of-function) [FER1L6 AS2](/details-gene/157376) could modulate its activity specifically in the affected neuronal populations, potentially minimizing off-target effects common with small molecule drugs that target ubiquitously expressed proteins.