Details for: DNAH10

Gene ID: 196385

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: DNAH10

Ensembl ID: ENSG00000197653

Description: dynein axonemal heavy chain 10

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • lung ciliated cell CL1000271
    CSI 6.73
    rCSI 7.79%
    PRS 99.12
  • ciliated epithelial cell CL0000067
    CSI 5.96
    rCSI 5.24%
    PRS 98.7
  • ependymal cell CL0000065
    CSI 5.85
    rCSI 11.88%
    PRS 96.93
  • multi-ciliated epithelial cell CL0005012
    CSI 5.6
    rCSI 5.58%
    PRS 99.07
  • ciliated cell CL0000064
    CSI 4.28
    rCSI 6.93%
    PRS 98.65
  • squamous epithelial cell CL0000076
    CSI 3.33
    rCSI 7.91%
    PRS 98.5
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 2.41
    rCSI 5.5%
    PRS 98.66
  • deuterosomal cell CL4033044
    CSI 1.49
    rCSI 5.04%
    PRS 98.6
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 1.19
    rCSI 4.28%
    PRS 98.27

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [DNAH10](/details-gene/196385) (dynein axonemal heavy chain 10) is a protein-coding gene located on chromosome 12q24.31. It encodes a heavy chain component of the dynein motor complex, a crucial molecular motor that drives the movement of cilia and flagella. Consistent with this function, [DNAH10](/details-gene/196385) is a highly specific and significant marker for various ciliated cell types, including those in the respiratory tract and the central nervous system. Its function is essential for processes dependent on ciliary motility, and mutations in this gene have been clinically linked to male infertility due to impaired sperm flagellar function ([Link](https://doi.org/10.1016/j.ajhg.2021.06.010)). ## Cellular Roles and Expression Landscape The expression profile of [DNAH10](/details-gene/196385) underscores its specialized role in powering motile cilia. **Overall**, the gene shows the highest significance in cell types defined by the presence of these organelles. The top-ranking cell types are functionally related and include [lung ciliated cell](/details-cell/CL1000271) (CSI: 6.73), [ciliated epithelial cell](/details-cell/CL0000067) (CSI: 5.96), [multi-ciliated epithelial cell](/details-cell/CL0005012) (CSI: 5.60), and [ciliated columnar cell of tracheobronchial tree](/details-cell/CL0002145) (CSI: 2.41). This expression pattern highlights its fundamental role in mucociliary clearance in the respiratory system. Beyond the airways, [DNAH10](/details-gene/196385) is also a significant marker for [ependymal cell](/details-cell/CL0000065) (CSI: 5.85), the ciliated cells lining the ventricles of the brain responsible for circulating cerebrospinal fluid. Its high significance in [deuterosomal cell](/details-cell/CL4033044) (CSI: 1.49), a progenitor cell involved in generating multiple cilia, further cements its association with ciliogenesis. The data strongly suggest that [DNAH10](/details-gene/196385) serves as a key functional component and a reliable marker for cells equipped with motile 9+2 axonemes. ## Pathways and Molecular Function The functional annotations for [DNAH10](/details-gene/196385) align precisely with its cellular expression profile. Its primary annotated biological process is [cilium movement involved in cell motility](/details-go/GO:0060294), which is the direct physiological outcome of its expression in the ciliated cells identified above. At the molecular level, its function is defined by its role as a motor protein. It exhibits [minus-end-directed microtubule motor activity](/details-go/GO:0008569), enabling it to move along the microtubule core of the axoneme. This movement is powered by its [ATP binding](/details-go/GO:0005524) and [ATP hydrolysis activity](/details-go/GO:0016887). Structurally, it is an integral part of the [dynein complex](/details-go/GO:0030286), located specifically within the [axoneme](/details-go/GO:0005930) of the [9+2 motile cilium](/details-go/GO:0097729). It also possesses binding domains for other dynein components, such as [dynein intermediate chain binding](/details-go/GO:0045505) and [dynein light intermediate chain binding](/details-go/GO:0051959), which are necessary for the assembly of the functional motor complex. ## Research Directions The well-defined role of [DNAH10](/details-gene/196385) in ciliary and flagellar motility, combined with its established link to human disease, opens several avenues for future investigation. The discovery that mutations in [DNAH10](/details-gene/196385) cause asthenoteratozoospermia (reduced sperm motility and abnormal morphology) provides a strong foundation for translational research ([Link](https://doi.org/10.1016/j.ajhg.2021.06.010)). Based on the available data, several testable hypotheses can be proposed: 1. Specific missense mutations within the ATPase domain of [DNAH10](/details-gene/196385) may selectively impair flagellar function in sperm while having subclinical effects on respiratory cilia, explaining why some patients present with isolated infertility rather than a broader primary ciliary dyskinesia (PCD) syndrome. 2. Given its high significance in [ependymal cell](/details-cell/CL0000065), hypomorphic or loss-of-function variants in [DNAH10](/details-gene/196385) could contribute to impaired cerebrospinal fluid (CSF) flow, potentially acting as a risk factor for congenital hydrocephalus or related neurological conditions. To test the first hypothesis, a compelling experimental approach would be to utilize CRISPR-Cas9 gene editing to introduce a specific patient-derived mutation into an in-vitro model of human spermatogenesis. For example, patient mutations could be engineered into human induced pluripotent stem cells (iPSCs), which are then differentiated into spermatid-like cells. The motility of the resulting flagella could be quantitatively analyzed using high-speed video microscopy, while the ultrastructure of the axoneme could be examined by transmission electron microscopy to identify defects in dynein arm assembly. As a therapeutic target, [DNAH10](/details-gene/196385) is not a candidate for inhibition due to its essential role in normal physiology. Instead, therapeutic strategies would focus on restoring its function. For monogenic diseases like [DNAH10](/details-gene/196385)-related male infertility, gene replacement therapy represents a potential future direction. AAV-mediated delivery of a functional copy of [DNAH10](/details-gene/196385) to spermatogonial stem cells could theoretically restore normal spermatogenesis, although significant technical and safety challenges remain for germline-targeted therapies.

Genular Protein ID: 1772860927

Symbol: DYH10_HUMAN

Name: Dynein axonemal heavy chain 10

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11175280

Title: Identification, tissue specific expression, and chromosomal localisation of several human dynein heavy chain genes.

PubMed ID: 11175280

DOI: 10.1038/sj.ejhg.5200555

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 34237282

Title: Bi-allelic mutations of DNAH10 cause primary male infertility with asthenoteratozoospermia in humans and mice.

PubMed ID: 34237282

DOI: 10.1016/j.ajhg.2021.06.010

Sequence Information:

  • Length: 4471
  • Mass: 514841
  • Checksum: 85D09303637E7D5C
  • Sequence:
  • MVPEEVEVEI DEIPVLSEEG EEEEETYSQK VESVDKVRAK RVSLRTESLG QPLNREDEEM 
    DKEISEKLPS KRTAKHIMEK MHLHMLCTPL PEEFLDQNVV FFLRNTKEAI SEATDMKEAM 
    EIMPETLEYG IINANVLHFL KNIICQVFLP ALSFNQHRTS TTVGVTSGEV SNSSEHESDL 
    PPMPGEAVEY HSIQLIRDEF LMNVQKFASN IQRTMQQLEG EIKLEMPIIS VEGEVSDLAA 
    DPETVDILEQ CVINWLNQIS TAVEAQLKKT PQGKGPLAEI EFWRERNATL SALHEQTKLP 
    IVRKVLDVIK ESDSMLVANL QPVFTELFKF HTEASDNVRF LSTVERYFKN ITHGSGFHVV 
    LDTIPAMMSA LRMVWIISRH YNKDERMIPL MERIAWEIAE RVCRVVNLRT LFKENRASAQ 
    SKTLEARNTL RLWKKAYFDT RAKIEASGRE DRWEFDRKRL FERTDYMATI CQDLSDVLQI 
    LEEFYNIFGP ELKAVTGDPK RIDDVLCRVD GLVTPMENLT FDPFSIKSSQ FWKYVMDEFK 
    IEVLIDIINK IFVQNLENPP LYKNHPPVAG AIYWERSLFF RIKHTILRFQ EVQEILDSDR 
    GQEVKQKYLE VGRTMKEYED RKYEQWMEVT EQVLPALMKK SLLTKSSIAT EEPSTLERGA 
    VFAINFSPAL REIINETKYL EQLGFTVPEL ARNVALQEDK FLRYTAGIQR MLDHYHMLIG 
    TLNDAESVLL KDHSQELLRV FRSGYKRLNW NSLGIGDYIT GCKQAIGKFE SLVHQIHKNA 
    DDISSRLTLI EAINLFKYPA AKSEEELPGV KEFFEHIERE RASDVDHMVR WYLAIGPLLT 
    KVEGLVVHTN TGKAPKLASY YKYWEKKIYE VLTKLILKNL QSFNSLILGN VPLFHTETIL 
    TAPEIILHPN TNEIDKMCFH CVRNCVEITK HFVRWMNGSC IECPPQKGEE EEVVIINFYN 
    DISLNPQIIE QAVMIPQNVH RILINLMKYL QKWKRYRPLW KLDKAIVMEK FAAKKPPCVA 
    YDEKLQFYSK IAYEVMRHPL IKDEHCIRLQ LRHLANTVQE NAKSWVISLG KLLNESAKEE 
    LYNLHEEMEH LAKNLRKIPN TLEDLKFVLA TIAEIRSKSL VMELRYRDVQ ERYRTMAMYN 
    LFPPDAEKEL VDKIESIWSN LFNDSVNVEH ALGDIKRTFT ELTRGEIMNY RVQIEEFAKR 
    FYSEGPGSVG DDLDKGVELL GVYERELARH EKSRQELANA EKLFDLPITM YPELLKVQKE 
    MSGLRMIYEL YEGLKVAKEE WSQTLWINLN VQILQEGIEG FLRALRKLPR PVRGLSVTYY 
    LEAKMKAFKD SIPLLLDLKN EALRDRHWKE LMEKTSVFFE MTETFTLENM FAMELHKHTD 
    VLNEIVTAAI KEVAIEKAVK EILDTWENMK FTVVKYCKGT QERGYILGSV DEIIQSLDDN 
    TFNLQSISGS RFVGPFLQTV HKWEKTLSLI GEVIEIWMLV QRKWMYLESI FIGGDIRSQL 
    PEEAKKFDNI DKVFKRIMGE TLKDPVIKRC CEAPNRLSDL QNVSEGLEKC QKSLNDYLDS 
    KRNAFPRFFF ISDDELLSIL GSSDPLCVQE HMIKMYDNIA SLRFNDGDSG EKLVSAMISA 
    EGEVMEFRKI LRAEGRVEDW MTAVLNEMRR TNRLITKEAI FRYCEDRSRV DWMLLYQGMV 
    VLAASQVWWT WEVEDVFHKA QKGEKQAMKN YGRKMHRQID ELVTRITMPL SKNDRKKYNT 
    VLIIDVHARD IVDSFIRGSI LEAREFDWES QLRFYWDREP DELNIRQCTG TFGYGYEYMG 
    LNGRLVITPL TDRIYLTLTQ ALSMYLGGAP AGPAGTGKTE TTKDLAKALG LLCVVTNCGE 
    GMDYRAVGKI FSGLAQCGAW GCFDEFNRID ASVLSVISSQ IQTIRNALIH QLTTFQFEGQ 
    EISLDSRMGI FITMNPGYAG RTELPESVKA LFRPVVVIVP DLQQICEIML FSEGFLEAKT 
    LAKKMTVLYK LAREQLSKQY HYDFGLRALK SVLVMAGELK RGSSDLREDV VLMRALRDMN 
    LPKFVFEDVP LFLGLISDLF PGLDCPRVRY PDFNDAVEQV LEENGYAVLP IQVDKVVQMF 
    ETMLTRHTTM VVGPTRGGKS VVINTLCQAQ TKLGLTTKLY ILNPKAVSVI ELYGILDPTT 
    RDWTDGVLSN IFREINKPTD KKERKYILFD GDVDALWVEN MNSVMDDNRL LTLANGERIR 
    LQAHCALLFE VGDLQYASPA TVSRCGMVYV DPKNLKYRPY WKKWVNQIPN KVEQYNLNSL 
    FEKYVPYLMD VIVEGIVDGR QAEKLKTIVP QTDLNMVTQL AKMLDALLEG EIEDLDLLEC 
    YFLEALYCSL GASLLEDGRM KFDEYIKRLA SLSTVDTEGV WANPGELPGQ LPTLYDFHFD 
    NKRNQWVPWS KLVPEYIHAP ERKFINILVH TVDTTRTTWI LEQMVKIKQP VIFVGESGTS 
    KTATTQNFLK NLSEETNIVL MVNFSSRTTS MDIQRNLEAN VEKRTKDTYG PPMGKRLLVF 
    MDDMNMPRVD EYGTQQPIAL LKLLLEKGYL YDRGKELNCK SIRDLGFIAA MGKAGGGRNE 
    VDPRFISLFS VFNVPFPSEE SLHLIYSSIL KGHTSTFHES IVAVSGKLTF CTLALYKNIV 
    QDLPPTPSKF HYIFNLRDLS RVFNGLVLTN PERFQTVAQM VRVWRNECLR VFHDRLISET 
    DKQLVQQHIG SLVVEHFKDD VEVVMRDPIL FGDFQMALHE GEPRIYEDIQ DYEAAKALFQ 
    EILEEYNESN TKMNLVLFDD ALEHLTRVHR IIRMDRGHAL LVGVGGSGKQ SLSRLAAFTA 
    SCEVFEILLS RGYSENSFRE DLKSLYLKLG IENKAMIFLF TDAHVAEEGF LELINNMLTS 
    GIVPALFSEE EKESILSQIG QEALKQGMGP AKESVWQYFV NKSANNLHIV LGMSPVGDTL 
    RTWCRNFPGM VNNTGIDWFM PWPPQALHAV AKSFLGYNPM IPAENIENVV KHVVLVHQSV 
    DHYSQQFLQK LRRSNYVTPK NYLDFINTYS KLLDEKTQCN IAQCKRLDGG LDKLKEATIQ 
    LDELNQKLAE QKIVLAEKSA ACEALLEEIA VNTAVAEEKK KLAEEKAMEI EEQNKVIAME 
    KAEAETTLAE VMPILEAAKL ELQKLDKSDV TEIRSFAKPP KQVQTVCECI LIMKGYKELN 
    WKTAKGVMSD PNFLRSLMEI DFDSITQSQV KNIKGLLKTL NTTTEEMEAV SKAGLGMLKF 
    VEAVMGYCDV FREIKPKREK VARLERNFYL TKRELERIQN ELAAIQKELE TLGAKYEAAI 
    LEKQKLQEEA EIMERRLIAA DKLISGLGSE NIRWLNDLDE LMHRRVKLLG DCLLCAAFLS 
    YEGAFTWEFR DEMVNRIWQN DILEREIPLS QPFRLESLLT DDVEISRWGS QGLPPDELSV 
    QNGILTTRAS RFPLCIDPQQ QALNWIKRKE EKNNLRVASF NDPDFLKQLE MSIKYGTPFL 
    FRDVDEYIDP VIDNVLEKNI KVSQGRQFII LGDKEVDYDS NFRLYLNTKL ANPRYSPSVF 
    GKAMVINYTV TLKGLEDQLL SVLVAYERRE LEEQREHLIQ ETSENKNLLK DLEDSLLREL 
    ATSTGNMLDN VDLVHTLEET KSKATEVSEK LKLAEKTALD IDRLRDGYRP AARRGAILFF 
    VLSEMALVNS MYQYSLIAFL EVFRLSLKKS LPDSILMKRL RNIMDTLTFS IYNHGCTGLF 
    ERHKLLFSFN MTIKIEQAEG RVPQEELDFF LKGNISLEKS KRKKPCAWLS DQGWEDIILL 
    SEMFSDNFGQ LPDDVENNQT VWQEWYDLDS LEQFPVPLGY DNNITPFQKL LILRCFRVDR 
    VYRAVTDYVT VTMGEKYVQP PMISFEAIFE QSTPHSPIVF ILSPGSDPAT DLMKLAERSG 
    FGGNRLKFLA MGQGQEKVAL QLLETAVARG QWLMLQNCHL LVKWLKDLEK SLERITKPHP 
    DFRLWLTTDP TKGFPIGILQ KSLKVVTEPP NGLKLNMRAT YFKISHEMLD QCPHPAFKPL 
    VYVLAFFHAV VQERRKFGKI GWNVYYDFNE SDFQVCMEIL NTYLTKAFQQ RDPRIPWGSL 
    KYLIGEVMYG GRAIDSFDRR ILTIYMDEYL GDFIFDTFQP FHFFRNKEVD YKIPVGDEKE 
    KFVEAIEALP LANTPEVFGL HPNAEIGYYT QAARDMWAHL LELQPQTGES SSGISRDDYI 
    GQVAKEIENK MPKVFDLDQV RKRLGTGLSP TSVVLLQELE RFNKLVVRMT KSLAELQRAL 
    AGEVGMSNEL DDVARSLFIG HIPNIWRRLA PDTLKSLGNW MVYFLRRFSQ YMLWVTESEP 
    SVMWLSGLHI PESYLTALVQ ATCRKNGWPL DRSTLFTQVT KFQDADEVNE RAGQGCFVSG 
    LYLEGADWDI EKGCLIKSKP KVLVVDLPIL KIIPIEAHRL KLQNTFRTPV YTTSMRRNAM 
    GVGLVFEADL FTTRHISHWV LQGVCLTLNS D

Genular Protein ID: 3386786247

Symbol: B0I1S1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 3319
  • Mass: 380794
  • Checksum: CA9A3C8A662A6AF1
  • Sequence:
  • KIESIWSNLF NDSVNVEHAL GDIKRTFTEL TRGEIMNYRV QIEEFAKRFY SEGPGSVGDD 
    LDKGVELLGV YERELARHEK SRQELANAEK LFDLPITMYP ELLKVQKEMS GLRMIYELYE 
    GLKVAKEEWS QTLWINLNVQ ILQEGIEGFL RALRKLPRPV RGLSVTYYLE AKMKAFKDSI 
    PLLLDLKNEA LRDRHWKELM EKTSVFFEMT ETFTLENMFA MELHKHTDVL NEIVTAAIKE 
    VAIEKAVKEI LDTWENMKFT VVKYCKGTQE RGYILGSVDE IIQSLDDNTF NLQSISGSRF 
    VGPFLQTVHK WEKTLSLIGE VIEIWMLVQR KWMYLESIFI GGDIRSQLPE EAKKFDNIDK 
    VFKRIMGETL KDPVIKRCCE APNRLSDLQN VSEGLEKCQK SLNDYLDSKR NAFPRFFFIS 
    DDELLSILGS SDPLCVQEHM IKMYDNIASL RFNDGDSGEK LVSAMISAEG EVMEFRKIVR 
    AEGRVEDWMT AVLNEMRRTN RLITKEAIFR YCEDRSRVDW MLLYQGMVVL AASQVWWTWE 
    VEDVFHKAQK GEKQAMKNYG RKMHRQIDEL VTRITMPLSK NDRKKYNTVL IIDVHARDIV 
    DSFIRGSILE AREFDWESQL RFYWDREPDE LNIRQCTGTF GYGYEYMGLN GRLVITPLTD 
    RIYLTLTQAL SMYLGGAPAG PAGTGKTETT KDLAKALGLL CVVTNCGEGM DYRAVGKIFS 
    GLAQCGAWGC FDEFNRIDAS VLSVISSQIQ TIRNALIHQL TTFQFEGQEI SLDSRMGIFI 
    TMNPGYAGRT ELPESVKALF RPVVVIVPDL QQICEIMLFS EGFLEAKTLA KKMTVLYKLA 
    REQLSKQYHY DFGLRALKSV LVMAGELKRG SSDLREDVVL MRALRDMNLP KFVFEDVPLF 
    LGLISDLFPG LDCPRVRYPD FNDAVEQVLE ENGYAVLPIQ VDKVVQMFET MLTRHTTMVV 
    GPTRGGKSVV INTLCQAQTK LGLTTKLYIL NPKAVSVIEL YGILDPTTRD WTDGVLSNIF 
    REINKPTDKK ERKYILFDGD VDALWVENMN SVMDDNRLLT LANGERIRLQ AHCALLFEVG 
    DLQYASPATV SRCGMVYVDP KNLKYRPYWK KWVNQIPNKV EQYNLNSLFE KYVPYLMDVI 
    VEGIVDGRQA EKLKTIVPQT DLNMVTQLAK MLDALLEGEI EDLDLLECYF LEALYCSLGA 
    SLLEDGRMKF DEYIKRLASL STVDTEGVWA NPGELPGQLP TLYDFHFDNK RNQWVPWSKL 
    VPEYIHAPER KFINILVHTV DTTRTTWILE QMVKIKQPVI FVGESGTSKT ATTQNFLKNL 
    SEETNIVLMV NFSSRTTSMD IQRNLEANVE KRTKDTYGPP MGKRLLVFMD DMNMPRVDEY 
    GTQQPIALLK LLLEKGYLYD RGKELNCKSI RDLGFIAAMG KAGGGRNEVD PRFISLFSVF 
    NVPFPSEESL HLIYSSILKG HTSTFHESIV AVSGKLTFCT LALYKNIVQD LPPTPSKFHY 
    IFNLRDLSRV FNGLVLTNPE RFQTVAQMVR VWRNECLRVF HDRLISETDK QLVQQHIGSL 
    VVEHFKDDVE VVMRDPILFG DFQMALHEGE PRIYEDIQDY EAAKALFQEI LEEYNESNTK 
    MNLVLFDDAL EHLTRVHRII RMDRGHALLV GVGGSGKQSL SRLAAFTASC EVFEILLSRG 
    YSENSFREDL KSLYLKLGIE NKAMIFLFTD AHVAEEGFLE LINNMLTSGI VPALFSEEEK 
    ESILSQIGQE ALKQGMGPAK ESVWQYFVNK SANNLHIVLG MSPVGDTLRT WCRNFPGMVN 
    NTGIDWFMPW PPQALHAVAK SFLGYNPMIP AENIENVVKH VVLVHQSVDH YSQQFLQKLR 
    RSNYVTPKNY LDFINTYSKL LDEKTQCNIA QCKRLDGGLD KLKEATIQLD ELNQKLAEQK 
    IVLAEKSAAC EALLEEIAVN TAVAEEKKKL AEEKAMEIEE QNKVIAMEKA EAETTLAEVM 
    PILEAAKLEL QKLDKSDVTE IRSFAKPPKQ VQTVCECILI MKGYKELNWK TAKGVMSDPN 
    FLRSLMEIDF DSITQSQVKN IKGLLKTLNT TTEEMEAVSK AGLGMLKFVE AVMGYCDVFR 
    EIKPKREKVA RLERNFYLTK RELERIQNEL AAIQKELETL GAKYEAAILE KQKLQEEAEI 
    MERRLIAADK LISGLGSENI RWLNDLDELM HRRVKLLGDC LLCAAFLSYE GAFTWEFRDE 
    MVNRIWQNDI LEREIPLSQP FRLESLLTDD VEISRWGSQG LPPDELSVQN GILTTRASRF 
    PLCIDPQQQA LNWIKRKEEK NNLRVASFND PDFLKQLEMS IKYGTPFLFR DVDEYIDPVI 
    DNVLEKNIKV SQGRQFIILG DKEVDYDSNF RLYLNTKLAN PRYSPSVFGK AMVINYTVTL 
    KGLEDQLLSV LVAYERRELE EQREHLIQET SENKNLLKDL EDSLLRELAT STGNMLDNVD 
    LVHTLEETKS KATEVSEKLK LAEKTALDID RLRDGYRPAA RRGAILFFVL SEMALVNSMY 
    QYSLIAFLEV FRLSLKKSLP DSILMKRLRN IMDTLTFSIY NHGCTGLFER HKLLFSFNMT 
    IKIEQAEGRV PQEELDFFLK GNISLEKSKR KKPCAWLSDQ GWEDIILLSE MFSDNFGQLP 
    DDVENNQTVW QEWYDLDSLE QFPVPLGYDN NITPFQKLLI LRCFRVDRVY RAVTDYVTVT 
    MGEKYVQPPM ISFEAIFEQS TPHSPIVFIL SPGSDPATDL MKLAERSGFG GNRLKFLAMG 
    QGQEKVALQL LETAVARGQW LMLQNCHLLV KWLKDLEKSL ERITKPHPDF RLWLTTDPTK 
    GFPIGILQKS LKVVTEPPNG LKLNMRATYF KISHEMLDQC PHPAFKPLVY VLAFFHAVVQ 
    ERRKFGKIGW NVYYDFNESD FQVCMEILNT YLTKAFQQRD PRIPWGSLKY LIGEVMYGGR 
    AIDSFDRRIL TIYMDEYLGD FIFDTFQPFH FFRNKEVDYK IPVGDEKEKF VEAIEALPLA 
    NTPEVFGLHP NAEIGYYTQA ARDMWAHLLE LQPQTGESSS GISRDDYIGQ VAKEIENKMP 
    KVFDLDQVRK RLGTGLSPTS VVLLQELERF NKLVVRMTKS LAELQRALAG EVGMSNELDD 
    VARSLFIGHI PNIWRRLAPD TLKSLGNWMV YFLRRFSQYM LWVTESEPSV MWLSGLHIPE 
    SYLTALVQAT CRKNGWPLDR STLFTQVTKF QDADEVNERA GQGCFVSGLY LEGADWDIEK 
    GCLIKSKPKV LVVDLPILKI IPIEAHRLKL QNTFRTPVYT TSMRRNAMGV GLVFEADLFT 
    TRHISHWVLQ GVCLTLNSD