Details for: ABCD1P2

Gene ID: 26983

Symbol: ABCD1P2

Ensembl ID: ENSG00000215151

Description: ATP binding cassette subfamily D member 1 pseudogene 2

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.0985
    Cell Significance Index: 13.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0238
    Cell Significance Index: 0.6400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.0069
    Cell Significance Index: 0.0900
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.0036
    Cell Significance Index: 0.0400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0045
    Cell Significance Index: -0.0500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0061
    Cell Significance Index: -0.0500
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0064
    Cell Significance Index: -0.0700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0065
    Cell Significance Index: -0.0600
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0086
    Cell Significance Index: -0.0800
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0091
    Cell Significance Index: -0.0600
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0102
    Cell Significance Index: -0.0700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0402
    Cell Significance Index: -0.3800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1156
    Cell Significance Index: -2.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene Status:** ABCD1P2 is a pseudogene, meaning it lacks a functional coding sequence, which is often a result of gene duplication and subsequent evolution. This classification raises questions about its potential roles and mechanisms of action. 2. **Expression Patterns:** ABCD1P2 is significantly expressed in stromal cells, neurons, and glutamatergic neurons, suggesting a possible involvement in tissue development, maintenance, and function. 3. **Evolutionary Conservation:** Despite being classified as a pseudogene, ABCD1P2 exhibits evolutionary conservation, indicating some level of functional relevance. 4. **Lack of Functional Annotation:** The gene's functional annotation is limited, and its potential roles in the immune system remain unclear. **Pathways and Functions:** 1. **ATP Binding Cassette Transporters:** The ABCD1 family of transporters is known for its role in transporting various molecules across cellular membranes. Although ABCD1P2 lacks a functional coding sequence, it is possible that it regulates the expression or activity of ABCD1 family members. 2. **Cell Signaling and Communication:** As expressed in neurons and glutamatergic neurons, ABCD1P2 may play a role in regulating cell signaling pathways, influencing neuronal development, and synaptic function. 3. **Stromal Cell Function:** In stromal cells, ABCD1P2 may contribute to maintaining tissue homeostasis, regulating the expression of other genes, or modulating immune responses. 4. **Immune System Modulation:** Although the exact mechanisms are unclear, ABCD1P2's expression in immune cells and its potential regulatory roles suggest that it may modulate immune responses or influence the function of immune cells. **Clinical Significance:** 1. **Neurological Disorders:** The expression of ABCD1P2 in neurons and glutamatergic neurons raises questions about its potential involvement in neurological disorders, such as Alzheimer's disease, Parkinson's disease, or epilepsy. 2. **Cancer and Immune Evasion:** The gene's expression in stromal cells and potential regulatory roles suggest that ABCD1P2 may contribute to cancer development, progression, or immune evasion. 3. **Immunotherapy and Vaccine Development:** Further research on ABCD1P2's potential functions and regulatory mechanisms may lead to the development of novel immunotherapies or vaccines targeting this gene. 4. **Gene Therapy and Gene Editing:** Understanding the role of ABCD1P2 in the immune system may inform gene therapy and gene editing strategies for treating diseases associated with this gene. In conclusion, the ABCD1P2 gene, despite being a pseudogene, holds significant potential for understanding the intricate mechanisms of the immune system. Further research is necessary to unravel the enigmatic roles of this gene and its potential applications in medicine.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.