Details for: IGHVII 33 1

Gene ID: 28369

Symbol: IGHVII 33 1

Ensembl ID: ENSG00000254203

Description: immunoglobulin heavy variable (II)-33-1 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T cell (CL0000084)
    Fold Change: 0.1431
    Cell Significance Index: 1.6900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.0054
    Cell Significance Index: 0.0500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.0026
    Cell Significance Index: 0.0300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.0005
    Cell Significance Index: 0.0100
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0042
    Cell Significance Index: -0.0400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0055
    Cell Significance Index: -0.0600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0092
    Cell Significance Index: -0.0700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0285
    Cell Significance Index: -0.2700
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0605
    Cell Significance Index: -0.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The IGHVII33-1 gene is a member of the immunoglobulin heavy chain superfamily, specifically belonging to the IGHVII family. As a pseudogene, it lacks a functional coding sequence, suggesting that it may have originated from a gene that has since been inactivated or lost through evolution. Notably, IGHVII33-1 is significantly expressed in double-negative thymocytes, double-positive thymocytes, and alpha-beta thymocytes, which are stages of T-cell development in the thymus. This expression pattern is unusual for pseudogenes, highlighting the complexity of gene regulation in immune cells. **Pathways and Functions:** The exact mechanisms underlying IGHVII33-1's expression and potential functions remain unclear. However, several hypotheses have been proposed: 1. **Regulatory role:** IGHVII33-1 may act as a regulatory element, influencing the expression of nearby genes or the overall transcriptional landscape of thymocytes. Its expression could be linked to the maintenance of T-cell repertoire diversity or the repression of pro-apoptotic genes. 2. **Epigenetic modulation:** IGHVII33-1 might interact with epigenetic regulators, modulating chromatin structure and influencing gene expression. This could have implications for the regulation of T-cell development and function. 3. **Non-coding RNA functions:** As a pseudogene, IGHVII33-1 may give rise to non-coding RNAs, which could have roles in RNA interference, microRNA regulation, or other post-transcriptional processes. **Clinical Significance:** While the clinical significance of IGHVII33-1 remains unclear, its expression in thymocytes raises several questions: 1. **Implications for T-cell development:** The presence of IGHVII33-1 in thymocytes may be linked to aberrant T-cell development or function, potentially contributing to autoimmune diseases or cancer. 2. **Cancer association:** Some studies have suggested a link between IGHVII33-1 expression and certain types of cancer, such as T-cell lymphoma. Further investigation is needed to confirm these findings. 3. **Diagnostic potential:** IGHVII33-1 could serve as a novel biomarker for T-cell malignancies or autoimmune diseases, offering new avenues for diagnostic and therapeutic approaches. In conclusion, the IGHVII33-1 gene, despite being a pseudogene, has sparked significant interest in the immunological community. Further research is necessary to elucidate its functional role in immune development and its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.