Details for: IGHD4 23

Gene ID: 28493

Symbol: IGHD4 23

Ensembl ID: ENSG00000227196

Description: immunoglobulin heavy diversity 4-23 (non-functional)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.2856
    Cell Significance Index: 32.7500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.0306
    Cell Significance Index: 16.6900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.1447
    Cell Significance Index: 1.8700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0925
    Cell Significance Index: -1.3400
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.2578
    Cell Significance Index: -3.0600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2782
    Cell Significance Index: -3.6500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -1.1621
    Cell Significance Index: -19.8600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -2.1695
    Cell Significance Index: -29.7500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -2.3677
    Cell Significance Index: -31.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHD4-23 is a member of the immunoglobulin heavy chain gene family, which plays a crucial role in the adaptive immune response. However, unlike its functional counterparts, IGHD4-23 lacks the typical immunoglobulin heavy chain constant domain, rendering it non-functional. Despite this, IGHD4-23 is significantly expressed in a wide range of hematopoietic cells, including erythrocytes, megakaryocytes, and immune cells. Its expression profile suggests a conserved role in hematopoiesis, where it may contribute to the development and differentiation of these cells. **Pathways and Functions:** IGHD4-23's non-functional nature belies its potential role in regulating hematopoiesis. Research suggests that IGHD4-23 may interact with other signaling pathways to modulate the behavior of hematopoietic cells. For instance, IGHD4-23 may influence the Notch signaling pathway, which is crucial for the development and differentiation of hematopoietic cells. Additionally, IGHD4-23 may influence the expression of other genes involved in hematopoiesis, such as those involved in erythropoiesis and megakaryopoiesis. While the precise mechanisms of IGHD4-23's action are unclear, its expression in a wide range of hematopoietic cells suggests a conserved role in regulating cellular behavior. **Clinical Significance:** IGHD4-23's clinical significance is multifaceted. Firstly, its expression in hematopoietic cells suggests that IGHD4-23 may play a role in the development of hematological disorders, such as hematopoietic malignancies. Secondly, IGHD4-23's interaction with other signaling pathways may provide insights into the molecular mechanisms underlying hematopoiesis. Finally, the study of IGHD4-23's expression profile may shed light on the role of non-functional genes in regulating cellular behavior and development. In conclusion, IGHD4-23 is a non-functional immunoglobulin heavy chain gene that has garnered attention in the scientific community due to its widespread expression in hematopoietic cells. While its non-functional nature may seem limiting, IGHD4-23's expression profile and potential interactions with other signaling pathways suggest a conserved role in regulating hematopoiesis. Further research is needed to fully elucidate IGHD4-23's clinical significance and its potential applications in the field of hematopoiesis.

Database document:

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