Details for: IGHD3 10

Gene ID: 28499

Symbol: IGHD3 10

Ensembl ID: ENSG00000211923

Description: immunoglobulin heavy diversity 3-10

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 2.8023
    Cell Significance Index: 36.2600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0443
    Cell Significance Index: 0.6400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.0045
    Cell Significance Index: 0.0500
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.0028
    Cell Significance Index: 0.0300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.7364
    Cell Significance Index: -12.5900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.9470
    Cell Significance Index: -24.1300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -1.5363
    Cell Significance Index: -24.8800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -1.7085
    Cell Significance Index: -23.4300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -1.7895
    Cell Significance Index: -23.5500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -1.7980
    Cell Significance Index: -23.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Structure:** The IGHD3 gene is located on the X chromosome, with a single copy in most individuals. It encodes a protein with a unique structure, consisting of a variable region and a constant region. 2. **Expression Profile:** IGHD3 is expressed in a wide range of immune cells, including precursor B cells, hematopoietic stem cells, and megakaryocyte-erythroid progenitor cells. Its expression is also observed in non-immune cells, such as erythrocytes and mast cells. 3. **Function:** IGHD3 is involved in the somatic hypermutation and class switch recombination processes, which are critical for generating antibody diversity and responding to changing antigenic environments. **Pathways and Functions:** 1. **Somatic Hypermutation:** IGHD3 is a key player in the somatic hypermutation process, which introduces point mutations into the immunoglobulin heavy chain gene. This process increases antibody affinity and diversity, allowing the immune system to adapt to changing pathogens. 2. **Class Switch Recombination:** IGHD3 is also involved in class switch recombination, a process that enables B cells to switch from producing one type of antibody to another. This process is essential for responding to different types of antigens. 3. **Gene Conversion:** IGHD3 is a target for gene conversion, a process that introduces non-sense mutations into the immunoglobulin heavy chain gene. This process can lead to the production of aberrant antibodies and autoimmune diseases. **Clinical Significance:** Dysregulation or aberrant expression of IGHD3 has been implicated in several immune-related disorders, including: 1. **Autoimmune Diseases:** IGHD3 dysfunction has been linked to autoimmune diseases such as rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Cancer:** IGHD3 expression has been observed in certain types of cancer, including lymphoma and leukemia. 3. **Immunodeficiency Disorders:** IGHD3 mutations have been identified in individuals with immunodeficiency disorders, such as X-linked agammaglobulinemia. In conclusion, the IGHD3 gene plays a critical role in the diversity of the immune system, and its dysregulation or aberrant expression can have significant clinical consequences. Further studies are necessary to fully understand the mechanisms by which IGHD3 influences immune function and to develop effective therapeutic strategies for immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.